September in preprints
Posted by the Node, on 2 October 2019
Welcome to our monthly trawl for developmental biology (and related) preprints.
In recent preprint news, CSHL, which runs bioRxiv, launched Transparent Review in Preprints (TRiP), a new project enabling journals and peer review services to post peer reviews of submitted manuscripts. In linked news EMBO Press and ASAPbio launched Review Commons, a platform that peer-reviews research manuscripts in the life sciences before submission to a journal, and enables authors to publicly post the reviews and their own response to them bioRxiv. Finally, PeerJ Preprints, regular source of preprints for this list, announced it would no longer be accepting new content. So long and thanks for all the preprints!
This month we found a typical wealth and breadth of preprints hosted on bioRxiv, PeerJ, and arXiv. Let us know if we missed anything, and use these links to get to the section you want:
Developmental biology
| Stem cells, regeneration & disease modelling
Evo-devo & evo
Cell biology
Modelling
Tools & resources
Research practice & education
Why not…
Developmental biology
| Patterning & signalling
A Human Accelerated Region participates in early human forebrain patterning and expansion
Sandra Acosta, Jaydeep Sidhaye, Luciano Fiore, Isabel Rollan, Giovanni Iacono, Alexander V. Misharin, Nozomu Takata, Martin Sikora, Nikita Joshi, Beisi Xu, Eske Willerslev, Holger Heyn, Miguel Manzanares, Juergen A. Knoblich, Guillermo Oliver
Fgf-driven Tbx protein activities directly induce myf5 and myod to initiate zebrafish myogenesis
Daniel P.S. Osborn, Kuoyu Li, Stephen J. Cutty, Andrew C. Nelson, Fiona C. Wardle, Yaniv Hinits, Simon M. Hughes
Cardiac competence of the head mesoderm fades concomitant with a shift towards the head skeletal muscle programme
Afnan Alzamrooni, Nicoletta Murciano, Susanne Dietrich
Adaptation Within Embryonic and Neonatal Heart Environment Reveals Alternative Fates for Adult c-Kit+ Cardiac Interstitial Cells
Bingyan J. Wang, Roberto Alvarez Jr, Alvin Muliono, Sharon Sengphanith, Megan M. Monsanto, Joi Weeks, Roberto Sacripanti, Mark A. Sussman
In vitro and in vivo roles of glucocorticoid and vitamin D receptors in the control of cardiomyocyte proliferative potential
Stephen Cutie, Dominic Lunn, Guo N. Huang
A signaling axis involving CNOT3, Aurora B and ERK promotes mesendodermal differentiation of ES cells in response to FGF2 and BMP4
Moumita Sarkar, Matteo Martufi, Monica Roman-Trufero, Yi-Fang Wang, Chad Whilding, Dirk Dormann, Pierangela Sabbattini, Niall Dillon
ISX-9 manipulates endocrine progenitor fate revealing conserved intestinal lineages in mouse and human.
Anastasia Tsakmaki, Patricia Fonseca Pedro, Polychronis Pavlidis, Bu Hussein Hayee, Gavin A Bewick
Distinct neural progenitor pools in the ventral telencephalon generate diversity in striatal spiny projection neurons
Fran van Heusden, Anežka Macey-Dare, Rohan N. Krajeski, Andrew Sharott, Tommas Jan Ellender
Persistent Cyfip1 expression is required to maintain the adult subventricular zone neurogenic niche
Christa Whelan Habela, Ki-Jun Yoon, Namshik Kim, Arens Taga, Kassidy Bell, Dwight E. Bergles, Nicholas J. Maragakis, Guo-li Ming, Hongjun Song
Mesolimbic microglia display regionally distinct developmental trajectories
KT Hope, IA Hawes, A Bonci, LM De Biase
Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain
C. Madore, Q. Leyrolle, L. Morel, J.C. Delpech, A.D. Greenhalgh, C. Lacabanne, C. Bosch-Bouju, J. Bourel, A. Thomazeau, K.E. Hopperton, S. Beccari, A. Sere, A. Aubert, V. De Smedt-Peyrusse, C. Lecours, K. Bisht, L. Fourgeaud, S. Gregoire, L. Bretillon, N. J. Grant, J. Badaut, P. Gressens, A. Sierra, O. Butovsky, M.E. Tremblay, R.P. Bazinet, C. Joffre, A. Nadjar, S. Layé
Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis
Stephanie Fore, Mehmet Ilyas Cosacak, Carmen Diaz Verdugo, Caghan Kizil, Emre Yaksi
The role of the diencephalon in the guidance of thalamocortical axons in mice
Idoia Quintana-Urzainqui, P Pablo Hernández-Malmierca, James M. Clegg, Ziwen Li, David J Price
Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog/Gli Is Required for Tracheoesophageal Separation
Talia Nasr, Pamela Mancini, Scott A. Rankin, Nicole A. Edwards, Zachary N. Agricola, Alan P. Kenny, Jessica L. Kinney, Keziah Daniels, Jon Vardanyan, Lu Han, Stephen L. Trisno, Sang-Wook Cha, James M. Wells, Matthew J. Kofron, Aaron M. Zorn
Notch signaling regulates Akap12 expression and primary cilia length during renal tubule morphogenesis
Malini Mukherjee, Ishara Ratnayake, Madhusudhana Janga, Eric Fogarty, Shania Scheidt, Justin Grassmeyer, Jennifer deRiso, Indra Chandrasekar, Phil Ahrenkiel, Raphael Kopan, Kameswaran Surendran
TGFβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration
Deepak A. Kaji, Kristen L. Howell, Alice H. Huang
Zic2 abrogates an alternative Wnt signaling pathway to convert axon attraction into repulsion
Cruz Morenilla-Palao, Maria Teresa López-Cascales, José P. López-Atalaya, Diana Baeza, Luis Calvo-Diaz, Aida Giner de Gracia, Angel Barco, Eloísa Herrera
ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling
Xiaoyun Sun, Xixia Peng, Yuqing Cao, Yan Zhou, Yuhua Sun
Elevated exposure to prenatal thyroid hormones affects embryonic mortality but has no effects into adulthood
Tom Sarraude, Bin-Yan Hsu, Ton G.G. Groothuis, Suvi Ruuskanen
Exposure to the RXR agonist SR11237 in early life causes disturbed skeletal morphogenesis in a rat model
Holly Dupuis, Michael Andrew Pest, Ermina Hadzic, Thin Xuan Vo, Daniel B. Hardy, Frank Beier
Robustness of the Dorsal morphogen gradient with respect to morphogen dosage
Hadel Al Asafen, Prasad U. Bandodkar, Sophia Carrell-Noel, Gregory T. Reeves
Drosophila Neuroblast Selection Gated by Notch, Snail, SoxB and EMT Gene Interplay
Badrul Arefin, Farjana Parvin, Shahrzad Bahrampour, Caroline Bivik Stadler, Stefan Thor
Presynaptic developmental plasticity allows robust sparse wiring of the Drosophila mushroom body
Najia A. Elkahlah, Jackson A. Rogow, E. Josephine Clowney
Activity manipulation of an excitatory interneuron, during an embryonic critical period, alters network tuning of the Drosophila larval locomotor circuit
Carlo N. G. Giachello, Yuen Ngan Fan, Matthias Landgraf, Richard A. Baines
New muscle identity code components identified by TRAP control shape and size of muscle subsets in Drosophila
Benjamin Bertin, Yoan Renaud, Teresa Jagla, Guillaume Lavergne, Cristiana Dondi, Jean-Philippe Da Ponte, Guillaume Junion, Krzysztof Jagla
Regulation of BMP Signaling by O-GlcNAcylation
Matthew Moulton, Gregory B. Humphreys, Alexander Kim, Anthea Letsou
Mechanism of Interaction of BMP and Insulin Signaling in C. elegans Development and Homeostasis
James F. Clark, Emma J. Ciccarelli, Gehan Ranepura, Muhammad S. Hasan, Alicia Meléndez, Cathy Savage-Dunn
Drosophila melanogaster Peroxisome Biogenesis Factor 7 plays a role in embryonic development
C Pridie, AJ Simmonds
Variability in β-catenin pulse dynamics in a stochastic cell fate decision in C. elegans
Jason R. Kroll, Jasonas Tsiaxiras, Jeroen S. van Zon
State transitions of a developmental oscillator
Milou W.M. Meeuse, Yannick P. Hauser, Gert-Jan Hendriks, Jan Eglinger, Guy Bogaarts, Charisios Tsiairis, Helge Großhans
Temporal scaling in developmental gene networks by epigenetic timing control
Phuc H.B. Nguyen, Nicholas A. Pease, Kenneth K.H. Ng, Blythe Irwin, Hao Yuan Kueh
Bacteria- and temperature-regulated peptides modulate beta-catenin signaling in Hydra
J Taubenheim, D Willoweit-Ohl, M Knop, S Franzenburg, TCG Bosch, S Fraune
| Morphogenesis & mechanics
Polarity protein distribution on the metaphase furrow regulates hexagon dominated plasma membrane organization in syncytial Drosophila embryos
Bipasha Dey, Debasmita Mitra, Tirthasree Das, Aparna Sherlekar, Ramya Balaji, Richa Rikhy
Pax2a regulates angiogenesis to facilitate mmp2-dependent basement membrane remodeling of the optic fissure
Megan L. Weaver, W. P Piedade, N.N Meshram, J.K. Famulski
Anisotropy links cell shapes to a solid-to-fluid transition during convergent extension
Xun Wang, Matthias Merkel, Leo B. Sutter, Gonca Erdemci-Tandogan, M. Lisa Manning, Karen E. Kasza
Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract
Pragya Sidhwani, Giulia L.M. Boezio, Hongbo Yang, Neil C. Chi, Beth L. Roman, Didier Y.R. Stainier, Deborah Yelon
VE-cadherin endocytosis controls vascular integrity and patterning during development
Cynthia M. Grimsley-Myers, Robin H. Isaacson, Chantel M. Cadwell, Jazmin Campos, Marina S. Hernandes, Kenneth R. Myers, Tadahiko Seo, William Giang, Kathy K. Griendling, Andrew P. Kowalczyk
Apical restriction of the planar cell polarity component VANGL in pancreatic ducts is required to maintain epithelial integrity
Lydie Flasse, Siham Yennek, Cédric Cortijo, Irene Seijo Barandiaran, Marine R-C Kraus, Anne Grapin-Botton
Intraflagellar transport complex B proteins regulate the Hippo effector Yap1 during cardiogenesis
Marina Peralta, Katerina Jerabkova, Tommaso Lucchesi, Laia Ortiz Lopez, Benjamin Vitre, Dong Han, Laurent Guillemot, Chaitanya Dingare, Izabela Sumara, Nadia Mercader, Virginie Lecaudey, Benedicte Delaval, Sigolène M. Meilhac, Julien Vermot
DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis
Miesje van der Stoel, Lilian Schimmel, Kalim Nawaz, Anne-Marieke van Stalborch, Annett de Haan, Alexandra Klaus-Bergmann, Erik T. Valent, Duco S. Koenis, Geerten P. van Nieuw Amerongen, Carlie J. de Vries, Vivian de Waard, Martijn Gloerich, Jaap D. van Buul, Stephan Huveneers
Primary cilium cAMP regulates cyclic saltatory neuronal migration at the centrosome
Julie Stoufflet, Maxime Chaulet, Mohamed Doulazmi, Coralie Fouquet, Caroline Dubacq, Christine Métin, Alain Trembleau, Pierre Vincent, Isabelle Caillé
Self-organised symmetry breaking in zebrafish reveals feedback from morphogenesis to pattern formation
Vikas Trivedi, Timothy Fulton, Andrea Attardi, Kerim Anlas, Chaitanya Dingare, Alfonso Martinez-Arias, Benjamin Steventon
Increasing demand for plasma membrane contributes to the energetic cost of early zebrafish embryogenesis
Jonathan Rodenfels, Pablo Sartori, Stefan Golfier, Kartikeya Nagendra, Karla Neugebauer, Jonathon Howard
Epithelial invagination by vertical telescoping
Jingjing Li, Andrew D. Economou, Jeremy B.A. Green
Elongations of epithelial colony in vitro: symmetry breaking through collective effects
Jordi Comelles, SS Soumya, S. Anvitha, Guillaume Salbreux, Frank Jülicher, Mandar M. Inamdar, Daniel Riveline
Fog signaling has diverse roles in epithelial morphogenesis in insects
Matthew A. Benton, Nadine Frey, Rodrigo Nunes da Fonseca, Cornelia von Levetzow, Dominik Stappert, Muhammad S. Hakeemi, Kai H. Conrads, Matthias Pechmann, Kristen A. Panfilio, Jeremy A. Lynch, Siegfried Roth
The localization of chitin synthase mediates the patterned deposition of chitin in developing Drosophila bristles
Paul N. Adler
| Genes & genomes
The nuclear to cytoplasmic ratio directly regulates zygotic transcription in Drosophila
Henry Wilky, Sahla Syed, João Raimundo, Bomyi Lim, Amanda A. Amodeo
Shadow enhancers suppress input transcription factor noise through distinct regulatory logic
Rachel Waymack, Alvaro Fletcher, German Enciso, Zeba Wunderlich
The conserved regulatory basis of mRNA contributions to the early Drosophila embryo differs between the maternal and zygotic genomes
Charles S. Omura, Susan E. Lott
In situ dissection of domain boundaries affect genome topology and gene transcription in Drosophila
Rodrigo G. Arzate-Mejía, Angel Josué Cerecedo-Castillo, Georgina Guerrero, Mayra Furlan-Magaril, Félix Recillas-Targa
Single-cell resolution view of the transcriptional landscape of developing Drosophila eye
Radoslaw Kamil Ejsmont, Grace Houser, Natalia Mora Garcia, Sara Fonseca Topp, Natalia Danda, Agnes Wong-Chung, Bassem A. Hassan
The transcriptional co-repressor CtBP is a negative regulator of growth that antagonizes the Yorkie and JNK/AP-1 pathways
Taryn M. Sumabat, Melanie I. Worley, Brett J. Pellock, Justin A. Bosch, Iswar K. Hariharan
Lineage-specific control of convergent cell identity by a Forkhead repressor
Karolina Mizeracka, Julia M. Rogers, Shai Shaham, Martha L. Bulyk, Maxwell G. Heiman
Germline RNA helicases couple RNA binding to P granule assembly at nuclear periphery
Wenjun Chen, Yabing Hu, Charles Lang, Jordan S Brown, Xiaoyan Song, Ed Munro, Karen Bennett, Donglei Zhang, Heng-Chi Lee
H3K9me2 protects lifespan against the transgenerational burden of germline transcription in C. elegans
Teresa W. Lee, Heidi S. David, Amanda K. Engstrom, Brandon S. Carpenter, David J. Katz
Cell-type diversity and regionalized gene expression in the planarian intestine revealed by laser-capture microdissection transcriptome profiling
David J. Forsthoefel, Nicholas I. Cejda, Umair W. Khan, Phillip A. Newmark
Eomes and Brachyury control pluripotency exit and germ layer segregation by changes of chromatin state
Jelena Tosic, Gwang-Jin Kim, Mihael Pavlovic, Chiara M. Schröder, Sophie-Luise Mersiowsky, Margareta Barg, Alexis Hofherr, Simone Probst, Michael Köttgen, Lutz Hein, Sebastian J. Arnold
Integrative genomic analysis of early neurogenesis reveals a temporal genetic program for differentiation and specification of preplate and Cajal-Retzius neurons
Jia Li, Lei Sun, Xue-Liang Peng, Xiao-Ming Yu, Shao-Jun Qi, Zhi John Lu, Jing-Dong J. Han, Qin Shen
Single-cell profiling and SCOPE-seq reveal the lineage dynamics of adult neurogenesis and NOTUM as a key V-SVZ regulator
Dogukan Mizrak, N. Sumru Bayin, Jinzhou Yuan, Zhouzerui Liu, Radu Suciu, Micah J. Niphakis, Nhi Ngo, Kenneth M. Lum, Benjamin F. Cravatt, Alexandra L. Joyner, Peter A. Sims
Discovery of genes required for body axis and limb formation by global identification of retinoic acid regulated enhancers and silencers
Marie Berenguer, Karolin F. Meyer, Jun Yin, Gregg Duester
Developmentally regulated tcf7l2 splice variants mediate transcriptional repressor functions during eye formation
Rodrigo M. Young, Kenneth B. Ewan, Veronica P. Ferrer, Miguel L. Allende, Jasminka Godovac-Zimmermann, Trevor C. Dale, Stephen W. Wilson
Deletions of distant regulatory sequences upstream of zebrafish pitx2 result in a range of ocular phenotypes
Eric Weh, Elena Sorokina, Kathryn Hendee, Doug B. Gould, Elena V. Semina
Atoh1 is repurposed from neuronal to hair cell determinant by Gfi1 acting as a coactivator without redistributing Atoh1’s genomic binding sites
Aida Costa, Lynn M. Powell, Abdenour Soufi, Sally Lowell, Andrew P. Jarman
Disruption of Capn15 in mice leads to brain and eye deficits
Congyao Zha, Carole A Farah, Vladimir Fonov, Richard Holt, Fabiola Ceroni, Nicola Ragge, David Rudko, Wayne S Sossin
STAG2 cohesin is essential for heart morphogenesis
Magali De Koninck, Eleonora Lapi, Claudio Badia-Careaga, Itziar Cossio, Daniel Gimenez-Llorente, Miriam Rodriguez-Corsino, Elena Andrada, Andres Hidalgo, Miguel Manzanares, Francisco X Real, Ana Losada
Cis-Regulatory Accessibility Directs Muller Glial Development and Regenerative Capacity
Leah S. VandenBosch, Stefanie G. Wohl, Matthew S. Wilken, Kristen Cox, Laura Chipman, Thomas A. Reh
STAT pathway activation limits the Ascl1-mediated chromatin remodeling required for neural regeneration from Müller glia in adult mouse retina
Nikolas L. Jorstad, Matthew S. Wilken, Levi Todd, Paul Nakamura, Nick Radulovich, Marcus J. Hooper, Alex Chitsazan, Brent A. Wilkerson, Fred Rieke, Thomas A. Reh
Transcriptomic Profiling of Developing Melanocortin Neurons Reveals a Role for Prdm12 in Energy Balance
Xiameng Chen, Steven C. Wyler, Li Li, Amanda G. Arnold, Rong Wan, Pin Xu, Chen Liu
Three-dimensional Genome Structure Reveals Distinct Chromatin Signatures of Mouse Female Germline Stem Cells During Development
Geng Tian, Xinyan Zhao, Wenhai Xie, Xiaoyong Li, Changliang Hou, Yinjuan Wang, Lijuan Wang, Xiaodong Zhao, Hua Li, Jing Li, Ji Wu
Direct evidence for transport of RNA from the mouse brain to the germline and offspring
Elizabeth A. O’Brien, Kathleen S. Ensbey, Bryan W. Day, Paul A. Baldock, Guy Barry
Patchy, incomplete, and heterogeneous X-inactivation in the human placenta
Tanya N. Phung, Kimberly C. Olney, Harvey J. Kliman, Melissa A. Wilson
Environmentally sensitive hotspots in the methylome of the early human embryo
MJ Silver, A Saffari, NJ Kessler, GR Chandak, CHD Fall, P Issarapu, A Dedaniya, M Betts, SE Moore, PT James, D Monk, AM Prentice
Developmental Genome-Wide DNA Methylation Asymmetry Between Mouse Placenta and Embryo
LM Legault, K Doiron, A Lemieux, M Caron, D Chan, FL Lopes, G Bourque, D Sinnett, S McGraw
Single-cell atlas of major haematopoietic tissues sheds light on blood cell formation from embryonic endothelium
Maya Shvartsman, Polina V. Pavlovich, Morgan Oatley, Kerstin Ganter, Rachel McKernan, Radvile Prialgauskaite, Artem Adamov, Konstantin Chukreev, Nicolas Descostes, Andreas Buness, Nina Cabezas-Wallscheid, Christophe Lancrin
Single cell transcriptome analysis reveals an essential role for Gata2b in hematopoietic lineage decisions in zebrafish
Emanuele Gioacchino, Cansu Koyunlar, Hans de Looper, Madelon de Jong, Tomasz Dobrzycki, Remco Hoogenboezem, Joke Peulen, Dennis Bosch, Paulette van Strien, Martin E van Royen, Pim J French, Eric Bindels, Rui Monteiro, Kirsten J Gussinklo, Ivo P Touw, Emma de Pater
Single-cell transcriptomic landscape of cardiac neural crest cell derivatives during embryonic and neonatal development
Xuanyu Liu, Wen Chen, Wenke Li, Ziyi Zeng, James R. Priest, Zhou Zhou
Single cell and single nucleus RNA-Seq reveal cellular heterogeneity and homeostatic regulatory networks in adult mouse stria vascularis
Soumya Korrapati, Ian Taukulis, Rafal Olszewski, Madeline Pyle, Shoujun Gu, Riya Singh, Carla Griffiths, Daniel Martin Izquierdo, Erich Boger, Robert J. Morell, Michael Hoa
Single cell transcriptomics reveals a signaling roadmap coordinating endoderm and mesoderm lineage diversification during foregut organogenesis
Lu Han, Hiroyuki Koike, Praneet Chaturvedi, Keishi Kishimoto, Kentaro Iwasawa, Kirsten Giesbrecht, Phillip C Witcher, Alexandra Eicher, Talia Nasr, Lauren Haines, John M Shannon, Mitsuru Morimoto, James M Wells, Takanori Takebe, Aaron M Zorn
Development of the Mouse and Human Cochlea at Single Cell Resolution
Kevin Shengyang Yu, Stacey M. Frumm, Jason S. Park, Katharine Lee, Daniel M. Wong, Lauren Byrnes, Sarah M. Knox, Julie B. Sneddon, Aaron D. Tward
Single-cell transcriptomic reveals temporal dynamics of critical regulators of germ cell fate during mouse sex determination
Chloé Mayère, Yasmine Neirijnck, Pauline Sararols, Isabelle Stévant, Françoise Kühne, Anne Amandine Chassot, Marie-Christine Chaboissier, Emmanouil T. Dermitzakis, Serge Nef
The enteric nervous system of the human and mouse colon at a single-cell resolution
Eugene Drokhlyansky, Christopher S. Smillie, Nicholas Van Wittenberghe, Maria Ericsson, Gabriel K. Griffin, Danielle Dionne, Michael S. Cuoco, Max N. Goder-Reiser, Tatyana Sharova, Andrew J. Aguirre, Genevieve M. Boland, Daniel Graham, Orit Rozenblatt-Rosen, Ramnik J. Xavier, Aviv Regev
| Stem cells, regeneration & disease modelling
A PUF hub drives self-renewal in C. elegans germline stem cells
Kimberly A. Haupt, Kimberley T. Law, Amy L. Enright, Charlotte R. Kanzler, Heaji Shin, Marvin Wickens, Judith Kimble
Single-cell time-series mapping of cell fate trajectories reveals an expanded developmental potential for human PSC-derived distal lung progenitors
Killian Hurley, Jun Ding, Carlos Villacorta-Martin, Michael J. Herriges, Anjali Jacob, Marall Vedaie, Konstantinos D. Alysandratos, Yuliang L. Sun, Chieh Lin, Rhiannon B. Werder, Andrew A. Wilson, Aditya Mithal, Gustavo Mostoslavsky, Ignacio S. Caballero, Susan H. Guttentag, Farida Ahangari, Naftali Kaminski, Alejo Rodriguez-Fraticelli, Fernando Camargo, Ziv Bar-Joseph, Darrell N Kotton
Universal and distinct features of intra-population heterogeneity between differentiated cells and pluripotent stem cells
Zhisheng Jiang, Serena Francesca Generoso, Marta Badia, Bernhard Payer, Lucas B. Carey
Induction of tracheal mesoderm and chondrocyte from pluripotent stem cells in mouse and human
Keishi Kishimoto, Kana T. Furukawa, Agustin LuzMadrigal, Akira Yamaoka, Chisa Matsuoka, Masanobu Habu, Cantas Alev, Aaron M. Zorn, Mitsuru Morimoto
Single cell transcriptomics of human epidermis reveals basal stem cell transition states
Shuxiong Wang, Michael L. Drummond, Christian F. Guerrero-Juarez, Eric Tarapore, Adam L. MacLean, Adam R. Stabell, Stephanie C. Wu, Guadalupe Gutierrez, Bao T. That, Claudia A. Benavente, Qing Nie, Scott X. Atwood
Two distinct trophectoderm lineage stem cells from human pluripotent stem cells
Adam Mischler, Victoria Karakis, Jessica Mahinthakumar, Celeste Carberry, Adriana San Miguel, Julia Rager, Rebecca Fry, Balaji M. Rao
Microtubules deform the nucleus and force chromatin reorganization during early differentiation of human hematopoietic stem cells
S. Biedzinski, L. Faivre, B. Vianay, M. Delord, L. Blanchoin, J. Larghero, M. Théry, S. Brunet
Mitochondria define intestinal stem cell differentiation downstream of a FOXO/Notch axis
M.C. Ludikhuize, M. Meerlo, M. Pages Gallego, M. Burgaya Julià, N.T.B. Nguyen, E. C. Brombacher, J.H. Paik, B.M. T. Burgering, M.J. Rodriguez Colman
Monocyte reconstitution and gut microbiota composition after hematopoietic stem cell transplantation
Sejal Morjaria, Allen W. Zhang, Sohn Kim, Jonathan U. Peled, Simone Becattini, Eric R. Littmann, Eric. G. Pamer, Miguel-Angel Perales, Michael C. Abt
Lgr5 Controls Extracellular Matrix Production By Stem Cells In The Developing Intestine
Valeria Fernandez Vallone, Morgane Leprovots, Romain Gerbier, Didac Ribatallada-Soriano, Anne Lefort, Frédérick Libert, Gilbert Vassart, Marie-Isabelle Garcia
Defining the adult hippocampal neural stem cell secretome: in vivo versus in vitro transcriptomic differences and their correlation to secreted protein levels
JK. Denninger, X. Chen, AM. Turkoglu, P. Sarchet, AR. Volk, P. Yan, ED. Kirby
Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids
Ashwani K. Gupta, Prasenjit Sarkar, Xinchao Pan, Thomas Carroll, Leif Oxburgh
Offspring production of ovarian organoids derived from spermatogonial stem cells by chromatin reorganization
Huacheng Luo, Xiaoyong Li, Geng G. Tian, Dali Li, Changliang Hou, Xinbao Ding, Lin Hou, Qifeng Lyu, Yunze Yang, Austin J. Cooney, Wenhai Xie, Ji Xiong, Hu Wang, Xiaodong Zhao, Ji Wu
Niche cells spatially restrict stem-cell self-renewal signaling via receptor-ligand degradation
Sophia Ladyzhets, Taylor Simao, Matthew Antel, Mayu Inaba
RNA-Seq analysis reveals pluripotency-associated genes and their interaction networks in human embryonic stem cells
Arindam Ghosh, Anup Som
Systematic assessment of regulatory effects of human disease variants in pluripotent cells
Marc Jan Bonder, Craig Smail, Michael J. Gloudemans, Laure Frésard, David Jakubosky, Matteo D’Antonio, Xin Li, Nicole M. Ferraro, Ivan Carcamo-Orive, Bogdan Mirauta, Daniel D. Seaton, Na Cai, Danilo Horta, YoSon Park, HipSci Consortium, iPSCORE Consortium, GENESiPS Consortium, PhLiPS Consortium, Erin N. Smith, Kelly A. Frazer, Stephen B. Montgomery, Oliver Stegle
Region-specific regulation of stem cell-driven regeneration in tapeworms
Tania Rozario, Edward B. Quinn, Jianbin Wang, Richard E. Davis, Phillip A. Newmark
PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS
Amanda C. Barber, Rachel S. Evans, Bart Nieuwenhuis, Craig S. Pearson, Joachim Fuchs, Amy R. MacQueen, Susan van Erp, Barbara Haenzi, Lianne A. Hulshof, Andrew Osborne, Raquel Conceicao, Sarita S. Deshpande, Joshua Cave, Charles ffrench-Constant, Patrice D. Smith, Klaus Okkenhaug, Britta J. Eickholt, Keith R. Martin, James W. Fawcett, Richard Eva
The pericardium promotes cardiac repair and remodelling post-myocardial infarction
Katie J. Mylonas, Lucy H. Jackson-Jones, Jack P. M. Andrews, Marlene S. Magalhaes, Marco Meloni, Nikhil V. Joshi, Judith E. Allen, David E. Newby, Marc R. Dweck, Gillian A. Gray, Cécile Bénézech
Senolytic treatment targets aberrant p21-expression to restore liver regeneration in adult mice
Birgit Ritschka, Tania Knauer-Meyer, Alba Mas, Jean-Luc Plassat, Daniel Sampaio Gonçalves, Hugues Jacobs, Elisa Pedone, Umberto Di Vicino, Maria Pia Cosma, William M. Keyes
Knocking out non-muscle myosin II in retinal ganglion cells promotes long-distance optic nerve regeneration
Xue-Wei Wang, Shu-Guang Yang, Chi Zhang, Jin-Jin Ma, Yingchi Zhang, Bin-Bin Yang, Yi-Lan Weng, Guo-Li Ming, Anish R. Kosanam, Saijilafu, Feng-Quan Zhou
Hexokinase 2 is dispensable for photoreceptor development but is required for survival during aging and outer retinal stress
Eric Weh, Zuzanna Lutrzykowska, Andrew Smith, Heather Hager, Mercy Pawar, Thomas Wubben, Cagri Besirli
Noncoding microdeletion in mouse Hgf disrupts neural crest migration into the stria vascularis, reduces the endocochlear potential and suggests the neuropathology for human nonsyndromic deafness DFNB39
Robert J. Morell, Rafal Olszewski, Risa Tona, Samuel Leitess, Julie M. Schultz, Elizabeth J. Thomason, Brittany N. Whitley, Connor Hill, Thomas Saunders, Matthew F. Starost, Tracy Fitzgerald, Elizabeth Wilson, Takahiro Ohyama, Thomas B. Friedman, Michael Hoa
Myogenesis modelled by human pluripotent stem cells uncovers Duchenne muscular dystrophy phenotypes prior to skeletal muscle commitment
Virginie Mournetas, Emmanuelle Massouridès, Jean-Baptiste Dupont, Etienne Kornobis, Hélène Polvèche, Margot Jarrige, Maxime R. F. Gosselin, Antigoni Manousopoulou, Spiros D. Garbis, Dariusz C. Górecki, Christian Pinset
Neurodevelopmental wiring deficits in the Ts65Dn mouse model of Down syndrome
Shruti Jain, Christina A. Watts, Wilson C.J. Chung, Kristy Welshhans
Loss of Nance-Horan Syndrome b (nhsb) prevents expansion growth of retinal progenitor cells by selective up-regulation of Δ113p53
Paul J. Vorster, John Ojumu, Amanda J. G. Dickinson, Gregory S. Walsh
Failure to clear developmental apoptosis contributes to the pathology of RNASET2-deficient leukoencephalopathy
Noémie Hamilton, Holly A. Rutherford, Hannah M. Isles, Jessica J. Petts, Thomas Weber, Marco Henneke, Jutta Gärtner, Mark Dunning, Stephen A. Renshaw
A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC–derived microglia
Thomas M Piers, Katharina Cosker, Anna Mallach, Gabriel Thomas Johnson, Rita Guerreiro, John Hardy, Jennifer M Pocock
Human embryoid bodies model basal lamina assembly and muscular dystrophy
Alec R. Nickolls, Michelle M. Lee, Kristen Zukosky, Barbara S. Mallon, Carsten G. Bönnemann
Derivation of oligodendrocyte precursor cells from human bone marrow stromal cells and use for re-myelination in the congenitally dysmyelinated brain
Guy Lam, Graham Ka-Hon Shea, Lap Kei Wu, Maximillian Li Tak Sui, Kwok Chun Hei, Zora Chan Chui Kuen, Yvonne Wong Cheuk Yin, Alex Yat Ping Tsui, Daisy Kwok Yan Shum, Ying Shing Chan
Network effects of the neuropsychiatric 15q13.3 microdeletion on the transcriptome and epigenome in human induced neurons
Siming Zhang, Xianglong Zhang, Shining Ma, Carolin Purmann, Kasey Davis, Wing Hung Wong, Jonathan Bernstein, Joachim Hallmayer, Alexander E Urban
| Plant development
Imaging plant germline differentiation within Arabidopsis flower by light sheet microscopy
Sona Valuchova, Pavlina Mikulkova, Jana Pecinkova, Jana Klimova, Michal Krumnikl, Patr Bainar, Stafan Heckmann, Pavel Tomancak, Karel Riha
A dynamic pattern of local auxin sources is required for root regeneration
Rotem Matosevich, Itay Cohen, Naama Gil-Yarom, Abelardo Modrego, Carla Verna, Enrico Scarpella, Idan Efroni
A cell surface O-glycosylated peptide, AGP21, acts on the brassinosteroid pathway and modulates root hair cell fate
Cecilia Borassi, Javier Gloazzo Dorosz, Martiniano M. Ricardi, Laercio Pol Fachin, Mariana Carignani, Eliana Marzol, Silvina Mangano, Diana Rosa Rodríguez Garcia, Javier Martínez Pacheco, Yossmayer del Carmen Rondón Guerrero, Silvia M. Velasquez, Bianca Villavicencio, Marina Ciancia, Georg Seifert, Hugo Verli, José M. Estevez
Duplicated KAI2 receptors with divergent ligand-binding specificities control distinct developmental traits in Lotus japonicus
Samy Carbonnel, Salar Torabi, Maximilian Griesmann, Elias Bleek, Yuhong Tang, Stefan Buchka, Veronica Basso, Mitsuru Shindo, Trevor L. Wang, Michael Udvardi, Mark Waters, Caroline Gutjahr
Loss of AUXIN RESPONSE FACTOR 4 function alters plant growth, stomatal functions and improves tomato tolerance to salinity and water deficit
Sarah Bouzroud, Maria Antonia Machado Barbosa, Karla Gasparini, Mouna Fahr, Najib Bendaou, Mondher Bouzayen, Agustin Zsögön, Abdelaziz Smouni, Mohamed Zouine
Spatial transcriptional signatures define margin morphogenesis along the proximal-distal and medio-lateral axes in complex leaf species Solanum lycopersicum (tomato)
Ciera C. Martinez, Siyu Li, Margaret R. Woodhouse, Keiko Sugimoto, Neelima R. Sinha
Fertility of Pedicellate Spikelets in Sorghum is Controlled by a Jasmonic Acid Regulatory Module
Nicholas Gladman, Yinping Jiao, Young Koung Lee, Lifang Zhang, Ratan Chopra, Michael Regulski, Gloria Burow, Chad Hayes, Shawn A. Christensen, Lavanya Dampanaboina, Junping Chen, John Burke, Doreen Ware, Zhanguo Xin
The maize Hairy Sheath Frayed1 (Hsf1) mutant alters leaf patterning through increased cytokinin signaling
Michael G. Muszynski, Lindsay Moss-Taylor, Sivanandan Chudalayandi, James Cahill, Angel R. Del Valle-Echevarria, Ignacio Alvarez-Castro, Abby Petefish, Hitoshi Sakakibara, Dmitry M. Krivosheev, Sergey N. Lomin, Georgy A. Romanov, Subbiah Thamotharan, Bailin Li, Norbert Brugière
HY5 is not integral to light mediated stomatal development in Arabidopsis
Nicholas Zoulias, Jordan Brown, James Rowe, Stuart A. Casson
Structural requirements of the phytoplasma effector protein SAP54 for causing homeotic transformation of floral organs
Marc-Benjamin Aurin, Michael Haupt, Matthias Görlach, Florian Rümpler, Günter Theißen
The ALBA RNA-binding proteins function redundantly to promote growth and flowering in Arabidopsis
Naiqi Wang, Meachery Jalajakumari, Thomas Miller, Mohsen Asadi, Anthony A Millar
A lipid code-dependent phosphoswitch directs PIN-mediated auxin efflux in Arabidopsis development
Shutang Tan, Xixi Zhang, Wei Kong, Xiao-Li Yang, Gergely Molnár, Jiří Friml, Hong-Wei Xue
Mutation of the ALBOSTRIANS Ohnologous Gene HvCMF3 Impairs Chloroplast Development and Thylakoid Architecture in Barley due to Reduced Plastid Translation
Mingjiu Li, Goetz Hensel, Michael Melzer, Astrid Junker, Henning Tschiersch, Daniel Arend, Jochen Kumlehn, Thomas Börner, Nils Stein
A RETINOBLASTOMA-RELATED transcription factor network governs egg cell differentiation and stress response in Arabidopsis
Olga Kirioukhova-Johnston, Pallavi Pawar, Geetha Govind, Pramod Pantha, René Lemcke, Vidhyadhar Nandana, Danaé S. Larsen, Alagarsamy M. Rhahul, Jubin N. Shah, Patrick von Born, Chathura Wijesinghege, Yue Zhou, Wilhelm Gruissem, Franziska Turck, Maheshi Dassanayake, Amal J. Johnston
Phytochrome light receptors control metabolic flux, and their action during seedling development sets the trajectory for biomass production
Johanna Krahmer, Ammad Abbas, Virginie Mengin, Hirofumi Ishihara, Thiago A Moraes, Nicole Krohn, Maria-Grazia Annunziata, Regina Feil, Saleh Alseekh, Toshihiro Obata, Alisdair R Fernie, Mark Stitt, Karen J. Halliday
Dissection of the early pollen-stigma interactions by live-cell imaging
Frédérique Rozier, Lucie Riglet, Chie Kodera, Vincent Bayle, Eléonore Durand, Thierry Gaude, Isabelle Fobis-Loisy
KAKU4-mediated deformation of the vegetative nucleus controls its precedent migration over sperm cells in pollen tubes
Chieko Goto, Kentaro Tamura, Satsuki Nishimaki, Naoki Yanagisawa, Kumi Matsuura-Tokita, Tetsuya Higashiyama, Daisuke Maruyama, Ikuko Hara-Nishimura
Programmed Cell Death in the Developing Brachypodium distachyon Grain
Safia Saada, Charles Ugochukwu Solomon, Sinéad Drea
The IDA cell separation pathway connects developmental and defense responses
Vilde Olsson, Elwira Smakowska-Luzan, Maike Breiden, Peter Marhavy, Rebecca Schneeweiss, Youssef Belkhadir, Rüdiger Simon, Melinka A. Butenko
Cytokinin promotes jasmonic acid accumulation in the control of maize leaf growth
Aimee N. Uyehara, Angel R. Del Valle-Echevarria, Charles T. Hunter, Hilde Nelissen, Kirin Demuynck, James F. Cahill, Georg Jander, Michael G. Muszynski
Temperature response of wheat affects final height and the timing of key developmental stages under field conditions
Lukas Kronenberg, Steven Yates, Martin P. Boer, Norbert Kirchgessner, Achim Walter, Andreas Hund
Initial embedding of TRANSPARENT TESTA GLABRA 1 in the Arabidopsis thaliana flowering time regulatory pathway
Barbara A M Paffendorf, Rawan Qassrawi, Andrea M Meys, Laura Trimborn, Andrea Schrader
Evo-devo & evo
Evolution of the growth plate into a spatially separated structure allows bone growth on land
Meng Xie, Pavel Gol’din, Anna Nele Herdina, Jordi Estefa, Ekaterina V Medvedeva, Lei Li, Phillip T Newton, Svetlana Kotova, Boris Shavkuta, Aditya Saxena, Lauren T Shumate, Brian Metscher, Karl Großschmidt, Shigeki Nishimori, Anastasia Akovantseva, Irene Linares Arregui, Paul Tafforeau, Kaj Fried, Mattias Carlström, Andras Simon, Christian Gasser, Henry M Kronenberg, Murat Bastepe, Kimberly L. Cooper, Peter Timashev, Sophie Sanchez, Igor Adameyko, Anders Eriksson, Andrei S Chagin
Interspecies transcriptome analyses identify genes that control the development and evolution of limb skeletal proportion
Aditya Saxena, Virag Sharma, Stanley J. Neufeld, Mai P. Tran, Haydee L. Gutierrez, Joel M. Erberich, Amanda Birmingham, John Cobb, Michael Hiller, Kimberly L. Cooper
Resegmentation is an ancestral feature of the gnathostome vertebral skeleton
Katharine E. Criswell, J. Andrew Gillis
nkx3.2 mutant zebrafish accommodate the jaw joint loss through a phenocopy of the head shapes of Paleozoic agnathans
Tetsuto Miyashita, Pranidhi Baddam, Joanna Smeeton, A. Phil Oel, Natasha Natarajan, Brogan Gordon, A. Richard Palmer, J. Gage Crump, Daniel Graf, W. Ted Allison
Profiling cellular diversity in sponges informs animal cell type and nervous system evolution
Jacob M. Musser, Klaske J. Schippers, Michael Nickel, Giulia Mizzon, Andrea B. Kohn, Constantin Pape, Jörg U. Hammel, Florian Wolf, Cong Liang, Ana Hernández-Plaza, Kaia Achim, Nicole L. Schieber, Warren R. Francis, Sergio Vargas R., Svenja Kling, Maike Renkert, Roberto Feuda, Imre Gaspar, Pawel Burkhardt, Peer Bork, Martin Beck, Anna Kreshuk, Gert Wörheide, Jaime Huerta-Cepas, Yannick Schwab, Leonid L. Moroz, Detlev Arendt
Evolutionary dynamics of the SKN-1 → MED → END-1,3 regulatory gene cascade in Caenorhabditis endoderm specification
Morris F. Maduro
Evolution of Larval Segment Position across 12 Drosophila Species
Gizem Kalay, Joel Atallah, Noemie C. Sierra, Austin M. Tang, Amanda E. Crofton, Mohan K. Murugesan, Sherri Wykoff-Clary, Susan E. Lott
Convergent evolution of sex−specific leg ornaments in Drosophilidae − from cells to structures
Kohtaro Tanaka, Olga Barmina, Jonathan H Massey, Artyom Kopp
Embryonic expression patterns of panarthropod Teneurin-m/odd Oz genes suggest a possible function in segmentation
Ralf Janssen
Blastodermal cuticle formation contributes to desiccation resistance in springtail eggs: eco-evolutionary implications for insect terrestrialization
Helena Carolina Martins Vargas, Kristen A. Panfilio, Dick Roelofs, Gustavo Lazzaro Rezende
Concordant developmental expression profiles of orthologues in highly divergent Bilateria
Luca Ferretti, Andrea Krämer-Eis, Philipp H. Schiffer
Sex-specific transgenerational plasticity in threespined sticklebacks
Jennifer K Hellmann, Syed Abbas Bukhari, Jack Deno, Alison M Bell
A tale of winglets: evolution of flight morphology in stick insects
Yu Zeng, Conner O’Malley, Sonal Singhal, Faszly Rahim, Sehoon Park, Xin Chen, Robert Dudley
Absence of a faster-X effect in beetles (Tribolium, Coleoptera)
Carrie A. Whittle, Arpita Kulkarni, Cassandra G. Extavour
Evidence of multifaceted functions of codon usage in translation within the model beetle Tribolium castaneum
Carrie A. Whittle, Arpita Kulkarni, Cassandra G. Extavour
Atlas of the Neuromuscular System in the Trachymedusa Aglantha digitale: Insights from the advanced hydrozoan
Tigran P. Norekian, Leonid L. Moroz
Ecological scaffolding and the evolution of individuality: the transition from cells to multicellular life
Andrew J Black, Pierrick Bourrat, Paul B Rainey
Cell biology
Myt1 kinase promotes mitotic cell cycle exit in Drosophila intestinal progenitor cells
Reegan J. Willms, Jie Zeng, Shelagh D. Campbell
Ser/Thr kinase Trc controls neurite outgrowth in Drosophila by modulating microtubule-microtubule sliding
Rosalind Norkett, Urko del Castillo, Wen Lu, Vladimir I. Gelfand
Human oocytes harbouring damaged dna can complete meiosis-i
Gaudeline Rémillard-Labrosse, Nicola Dean, Adélaïde Allais, Aleksandar I. Mihajlović, Shao Guang Jin, Weon-Young Son, Jin-Tae Chung, Melissa Pansera, Sara Henderson, Alina Mahfoudh, Naama Steiner, Kristy Agapitou, Petros Marangos, William Buckett, Jacob Ligeti-Ruiter, Greg FitzHarris
TPM3.1 association with actin stress fibers is required for lens epithelial to mesenchymal transition
Justin Parreno, Michael B. Amadeo, Elizabeth H. Kwon, Velia M. Fowler
Reactivation of chromosome signalling induces reversal of the meiotic program
Maikel Castellano-Pozo, Sarai Pacheco, Georgios Sioutas, Angel Luis Jaso-Tamame, Marian H Dore, Enrique Martinez-Perez
Function of TRIP6 in brain-specific ciliogenesis
Shalmali Shukla, Pavel Urbanek, Lucien Frappart, Ronny Hänold, Sigrun Nagel, Shamci Monajembashi, Paulius Grigaravicius, Woo Kee Min, Alicia Tapias, Olivier Kassel, Heike Heuer, Zhao-Qi Wang, Aspasia Ploubidou, Peter Herrlich
Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation
Georgi Dimchev, Behnam Amiri, Ashley C. Humphries, Matthias Schaks, Vanessa Dimchev, Theresia E.B. Stradal, Jan Faix, Matthias Krause, Michael Way, Martin Falcke, Klemens Rottner
Phenotypic and functional characterization of corneal endothelial cells during in vitro expansion
Ricardo F. Frausto, Vinay S. Swamy, Gary S. L. Peh, Payton M. Boere, E. Maryam Hanser, Doug. D. Chung, Benjamin L. George, Marco Morselli, Liyo Kao, Rustam Azimov, Jessica Wu, Matteo Pellegrini, Ira Kurtz, Jodhbir S. Mehta, Anthony J. Aldave
Crumbs organizes the transport machinery by regulating apical levels of PI(4,5)P2 in Drosophila
Johanna Lattner, Weihua Leng, Elisabeth Knust, Marko Brankatschk, David Flores-Benitez
NRP2 as an emerging angiogenic player; promoting endothelial cell adhesion and migration by regulating recycling of α5 integrin
Abdullah AA Alghamdi, Christopher J Benwell, Samuel J Atkinson, Jordi Lambert, Stephen D Robinson
Modelling
Universality of clone dynamics during tissue development
Steffen Rulands, Fabienne Lescroart, Samira Chabab, Christopher J. Hindley, Nicole Prior, Magdalena K. Sznurkowska, Meritxell Huch, Anna Philpott, Cedric Blanpain, Benjamin D. Simons
Modeling binary and graded cone cell fate patterning in the mouse retina
Kiara C. Eldred, Cameron Avelis, Robert J. Johnston Jr., Elijah Roberts
A theoretical model of neural maturation in the developing spinal cord
Piyush Joshi, Isaac Skromne
Evaluation of BMP-mediated patterning in a 3D mathematical model of the zebrafish blastula embryo
Linlin Li, Xu Wang, Mary C. Mullins, David M. Umulis
Data-theoretical Synthesis of the Early Developmental Process
Bradly Alicea, Richard Gordon, Thomas E. Portegys
Multiscale mechanical model for cell division orientation in developing biological systems
B. Leggio, J. Laussu, E. Faure, View P. Lemaire, C. Godin
Quantitative analysis of the dynamics of maternal gradients of the early Drosophila embryo
Victoria Yu. Samuta, Alexander V. Spirov
The recent advances in the mathematical modelling of human pluripotent stem cells
L E Wadkin, S Orozco-Fuentes, I Neganova, M Lako, A Shukurov, N G Parker
Tools & resources
A bestiary of genetic mouse lines and related tools for inducible and reversible intersectional misexpression
Elham Ahmadzadeh, Aditi Singh, N. Sumru Bayin, Xinli Qu, Linda Madisen, Daniel Stephen, Hongkui Zeng, Alexandra L. Joyner, Alberto Rosello-Diez
An optimized protocol for iDISCO+ rat brain clearing, imaging, and analysis
Audrey Branch, Daniel Tward, Joshua T Vogelstein, Zhuhao Wu, Michela Gallagher
Xmas ESC: A new female embryonic stem cell system that reveals the BAF complex as a key regulator of the establishment of X chromosome inactivation
Andrew Keniry, Natasha Jansz, Linden J. Gearing, Iromi Wanigasuriya, Joseph Chen, Christian M. Nefzger, Peter F. Hickey, Quentin Gouil, Joy Liu, Kelsey A. Breslin, Megan Iminitoff, Tamara Beck, Andres Tapia del Fierro, Lachlan Whitehead, Sarah A. Kinkel, Phillippa C. Taberlay, Tracy Willson, Miha Pakusch, Matthew E. Ritchie, Douglas J. Hilton, Jose M. Polo, Marnie E. Blewitt
StemBond hydrogels optimise the mechanical microenvironment for embryonic stem cells
Céline Labouesse, Chibeza C. Agley, Bao Xiu Tan, Moritz Hofer, Alex Winkel, Giuliano G. Stirparo, Hannah T. Stuart, Christophe M. Verstreken, William Mansfield, Paul Bertone, Kristian Franze, Jose C. R. Silva, Kevin J. Chalut
Negligible-Cost and Weekend-Free Chemically Defined Human iPSC Culture
Hui-Hsuan Kuo, Xiaozhi Gao, Jean-Marc DeKeyser, K. Ashley Fetterman, Emily A. Pinheiro, Carly J. Weddle, Hananeh Fonoudi, Michael V. Orman, Marisol Romero-Tejeda, Mariam Jouni, Malorie Blancard, Tarek Magdy, Conrad L. Epting, Alfred L. George Jr., Paul W. Burridge
Serum-free culture system for spontaneous human mesenchymal stem cell spheroids formation
Guoyi Dong, Shengpeng Wang, Yuping Ge, Qiuting Deng, Qi Cao, Quanlei Wang, Zhouchun Shang, Wenjie OuYang, Jing Li, Chao Liu, Jie Tang, Weihua Zhao, Ying Gu
Defined factors to reactivate cell cycle activity in adult mouse cardiomyocytes
Justin Judd, Jonathan Lovas, Guo N. Huang
Rapid degradation of C. elegans proteins at single-cell resolution with a synthetic auxin
Michael A. Q. Martinez, Brian A. Kinney, Taylor N. Medwig-Kinney, Guinevere Ashley, James M. Ragle, Londen Johnson, Joseph Aguilera, Christopher M. Hammell, Jordan D. Ward, David Q. Matus
dotdotdot: an automated approach to quantify multiplex single molecule fluorescent in situ hybridization (smFISH) images in complex tissues
Kristen R. Maynard, Madhavi Tippani, Yoichiro Takahashi, BaDoi N. Phan, Thomas M. Hyde, Andrew E. Jaffe, Keri Martinowich
Cell type specific novel lincRNAs and circRNAs in the BLUEPRINT haematopoietic transcriptomes atlas
Luigi Grassi, Osagie G. Izuogu, Natasha A.N. Jorge, Denis Seyres, Mariona Bustamante, Frances Burden, Samantha Farrow, Neda Farahi, Fergal J. Martin, Adam Frankish, Jonathan M. Mudge, Myrto Kostadima, Romina Petersen, John J. Lambourne, Sophia Rowlston, Enca Martin-Rendon, Laura Clarke, Kate Downes, Xavier Estivill, Paul Flicek, Joost H.A. Martens, Marie-Laure Yaspo, Hendrik G. Stunnenberg, Willem H. Ouwehand, Fabio Passetti, Ernest Turro, Mattia Frontini
ECM-body: A cell-free 3D biomimetic scaffold derived from intact planarian body
Ekasit Sonpho, Chanida Wootthichairangsan, Miyuki Ishida, Takeshi Inoue, Kiyokazu Agata, Anchuleerat Maleehuan, Komgrid Charngkaew, Nusara Chomanee, Saengduen Moonsom, Patompon Wongtrakoongate, Arthit Chairoungdua, Puey Ounjai
New additions to the CRISPR toolbox: CRISPR-CLONInG and CRISPR-CLIP
Dorjee T.N. Shola
Highly efficient and specific genome editing in human cells with paired CRISPR-Cas9 nickase ribonucleoproteins
Jacob Lamberth, Laura Daley, Pachai Natarajan, Stanislav Khoruzhenko, Nurit Becker, Daniel Taglicht, Gregory D. Davis, Qingzhou Ji
Gene knock-ins in Drosophila using homology-independent insertion of universal donor plasmids
Justin A. Bosch, Ryan Colbeth, Jonathan Zirin, Norbert Perrimon
Generation of fluorescent cell-derived-matrix to study 3D cell migration
Amélie Luise Godeau, Hélène Delanoë-Ayari, Daniel Riveline
Fly-QMA: Automated analysis of mosaic imaginal discs in Drosophila
Sebastian Bernasek, Nicolás Peláez, Richard Carthew, Neda Bagheri, Luís Amaral
System-Level Quantification and Phenotyping of Early Embryonic Morphogenesis of Caenorhabditis elegans
Guoye Guan, Ming-Kin Wong, Vincy Wing Sze Ho, Xiaomeng An, Lu-Yan Chan, Binghui Tian, Zhiyuan Li, Leihan Tang, Zhongying Zhao, Chao Tang
Regeneration Rosetta: An interactive web application to explore regeneration-associated gene expression and chromatin accessibility
Andrea Rau, Sumona P. Dhara, Ava J. Udvadia, Paul L. Auer
A versatile bulk electrotransfection protocol for mouse embryonic fibroblast and iPS cells
Shahin Eghbalsaied, Iqbal Hyder, Wilfried A. Kues
Research practice & education
LAB-AID (Laboratory Automated Interrogation of Data): an interactive web application for visualization of multi-level data from biological experiments
Zrinko Kozic, Sam Booker, Owen Dando, Peter Kind
Can scientists fill the science journalism void? Online public engagement with science stories authored by scientists
Yael Barel-Ben David, Erez S. Garty, Ayelet Baram-Tsabari
fCite: a fractional citation tool to quantify an individual’s scientific research output
Lukasz Pawel Kozlowski
COPO: a metadata platform for brokering FAIR data in the life sciences
Anthony Etuk, Felix Shaw, Alejandra Gonzalez-Beltran, David Johnson, Marie-Angélique Laporte, Philippe Rocca-Serra, Elizabeth Arnaud, Medha Devare, Paul J Kersey, Susanna-Assunta Sansone, Robert P Davey
Why not…
Why does a flying fish taxi on sea surface before take-off? A hydrodynamic interpretation
Jian Deng, Shuhong Wang, Lingxin Zhang, Xuerui Mao
Resurrecting the ancient glow
Yuichi Oba, Kaori Konishi, Daichi Yano, Hideyuki Shibata, Dai-ichiro Kato, Tsuyoshi Shirai
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