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September in preprints

Posted by , on 4 October 2023

Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints.

The preprints this month are hosted on bioRxiv – use these links below to get to the section you want:

Developmental biology

Cell Biology

Modelling

Reviews

Tools & Resources

Research practice & education

Developmental biology

| Patterning & signalling

Protein phosphatase 1 regulates core PCP signaling

Song Song, Bomsoo Cho, Alexis T Weiner, Silas Boye Nissen, Irene Ojeda Naharros, Pablo Sanchez Bosch, Kaye Suyama, Yanhui Hu, Li He, Tanya Svinkina, Namrata Udeshi, Steven A Carr, Norbert Perrimon, Jeffrey D. Axelrod

Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning

Bruno C. Vellutini, José M. Martín-Durán, Aina Børve, Andreas Hejnol

SMAD4 promotes somatic-germline contact during oocyte growth

Sofia Granados-Aparici, Qin Yang, Hugh Clarke

From Granados-Aparici et al. This image is made available under a CC-BY-NC 4.0 International license.

Prickle and Ror modulate Dishevelled-Vangl interaction to regulate non-canonical Wnt signaling during convergent extension

Jianbo Wang, Chenbei Chang, Hwa-seon Seo, Deli Yu, Ivan Popov, Jiahui Tao, Allyson Angermeier, Bingdong Sha, Jeffrey D. Axelrod

Functional opsin patterning for Drosophila color vision is established through signaling pathways in adjacent object-detection neurons

Manabu Kitamata, Yoshiaki Otake, Hideaki Kitagori, Xuanshuo Zhang, Yusuke Maki, Rika Boku, Masato Takeuchi, Hideki Nakagoshi

Cell proliferation and Notch signaling coordinate the formation of epithelial folds in the Drosophila leg

Alonso Rodriguez, Sergio Cordoba, Daniel Delipe-Cordero, Antonio Baonza, David Miguez, Carlos Estella

Notch signalling plays a critical role in patterning the ventral mesoderm during early embryogenesis in Drosophila melanogaster

Marvel Megaly, Gregory Foran, Arsala Ali, Anel Turgambayeva, Ryan D. Hallam, Aleksandar Necakov

Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts

Yongfeng Luo, Ke Cao, Joanne Chiu, Hui Chen, Hong-Jun Wang, Matthew E. Thornton, Brendan H. Grubbs, Martin Kolb, Michael S. Parmacek, Yuji Mishina, Wei Shi

Cell autonomous polarization by the planar cell polarity signaling pathway

Alexis T Weiner, Bomsoo Cho, Kaye Suyama, Jeffrey D Axelrod

BMP signaling pathway member expression is enriched in enteric neural progenitors and required for zebrafish enteric nervous system development

Joshua A. Moore, Arielle S. Noah, Eileen W. Singleton, Rosa A. Uribe

Flamingo participates in multiple models of cell competition

Pablo Sanchez Bosch, Bomsoo Cho, Jeffrey D. Axelrod

Social administration of juvenile hormone to larvae increases body size and nutritional needs for pupation

Matteo A. Negroni, Adria C. LeBoeuf

Src/Fas2-dependent Ephrin phosphorylation initiates Eph/Ephrin reverse signaling through Rac1 to shape columnar units in the fly brain

Miaoxing Wang, Xujun Han, Yunfei Lee, Rie Takayama, Makoto Sato

Embryogenesis in myrmicine ants combines features of short and long germ-band modes of development

Chi-Chun Fang, Arjuna Rajakumar, Andrew Kenny, Ulrich G. Mueller, Ehab Abouheif, David Stein

From Fang et al. This image is made available under a CC-BY-NC-ND 4.0 International license.

Myosin1G promotes Nodal signaling to control Zebrafish Left-Right asymmetry

Akshai Janardhana Kurup, Florian Bailet, Maximilian Fürthauer

Delta-dependent Notch activation closes the early neuroblast temporal program to promote lineage progression and neurogenesis termination in Drosophila

Chhavi Sood, Md Ausrafuggaman Nahid, Kendall R. Branham, Matthew C. Pahl, Susan E. Doyle, Sarah E. Siegrist

| Morphogenesis & mechanics

Complex relationship among vessel diameter, shear stress and blood pressure controlling vessel pruning during angiogenesis

Vivek Kumar, Prashant Kumar, Takao Hikita, Mingqian Ding, Yukinori Kametani, Masanori Nakayama, Yosuke Hasegawa

Left-right asymmetry is formed in the basal bodies of the mouse node cilia in a cilia motility-dependent manner

Hiroshi Yoke, Atsushi Taniguchi, Shigenori Nonaka

Exploring the principles of embryonic mammary gland branching morphogenesis

Riitta Lindström, Jyoti P. Satta, Satu-Marja Myllymäki, Qiang Lan, Ewelina Trela, Renata Prunskaite-Hyyryläinen, Beata Kaczyńska, Maria Voutilainen, Satu Kuure, Seppo J. Vainio, Marja L. Mikkola

An actomyosin network organizes niche morphology and responds to feedback from recruited stem cells

Bailey N. Warder, Kara A. Nelson, Justin Sui, Lauren Anllo, Stephen DiNardo

Molecular control of cellulosic fin morphogenesis in ascidians

Maxence LANOIZELET, Christel ELKHOURY YOUHANNA, SébasBen DARRAS

Illuminating the Terminal Nerve: Uncovering the Link between GnRH-1 and Olfactory Development

Enrico Amato Jr, Ed Zandro M Taroc, Paolo E. Forni

Myocardin-related transcription factors regulate morphogenetic events in vertebrate embryos by controlling F-actin organization and apical constriction

Keiji Itoh, Olga Ossipova, Miho Matsuda, Sergei Y Sokol

PCP and Septins govern the polarized organization of the actin cytoskeleton during convergent extension

Caitlin C Devitt, Shinuo Weng, Vidal D Bejar-Padilla, José Alvarado, John B Wallingford

Sensitivity of the timing of Drosophila pupal wing morphogenesis to external perturbations

Romina Piscitello-Gómez, Ali Mahmoud, Natalie A Dye, Suzanne Eaton

Overburdened Ferroptotic Stress Impairs Tooth Morphogenesis

H.S. Wang, X.F. Wang, L.Y. Huang, C.L. Wang, F.Y. Yu, L. Ye

From Wang et al. This image is made available under a CC-BY 4.0 International license.

Basal spot junctions of epithelial tissues respond to morphogenetic forces and regulate Hippo signaling

Benjamin Kroeger, Samuel A. Manning, Yoshana Fonseka, Viola Oorschot, Simon A. Crawford, Georg Ramm, Kieran F. Harvey

Elevated temperature fatally disrupts nuclear divisions in the early Drosophila embryo

Girish Kale, Pratika Agarwal, J Jaime Diaz-Larrosa, Steffen Lemke

| Genes & genomes

The autism-associated gene SYNGAP1 regulates human cortical neurogenesis

Marcella Birtele, Ashley Del Dosso, Tiantian Xu, Tuan Nguyen, Brent Wilkinson, Negar Hosseini, Sarah Nguyen, Jean-Paul Urenda, Gavin Knight, Camilo Rojas, Ilse Flores, Alexander Atamian, Roger Moore, Ritin Sharma, Patrick Pirrotte, Randolph S. Ashton, Eric J. Huang, Gavin Rumbaugh, Marcelo P. Coba, Giorgia Quadrato

The differentiation and integration of the hippocampal dorsoventral axis are controlled by two nuclear receptor genes

Xiong Yang, Rong Wan, Zhiwen Liu, Su Feng, Jiaxin Yang, Naihe Jing, Ke Tang

SoxB1 transcription factors are essential for initiating and maintaining the neural plate border gene expression

Elizabeth N. Schock, Joshua R York, Austin P Li, Ashlyn Y Tu, Carole LaBonne

ARID1A governs the silencing of sex-linked transcription during male meiosis in the mouse

Debashish U Menon, Prabuddha Chakraborty, Noel Murcia, Terry Magnuson

Characterization of the zebrafish gabra1sa43718/sa43718 germline loss of function allele confirms a function for Gabra1 in motility and nervous system development

David Paz, Nayeli G. Reyes-Nava, Briana E. Pinales, Isaiah Perez, Claudia B. Gil, Annalise V. Gonzales, Brian Grajeda, Igor L. Estevao, Cameron C. Ellis, Victoria L. Castro, Anita M. Quintana

Post-transcriptional repression of mRNA enhances competence to transit from mitosis to meiosis in mouse spermatogenic cells

Maria M. Mikedis, Bingrun Liu, Dirk G. de Rooij, David C. Page

Unraveling the role of Xist in X chromosome inactivation: insights from rabbit model and deletion analysis of exons and repeat A

Mingming Liang, Lichao Zhang, Liangxue Lai, Zhanjun Li

Paternal starvation affects metabolic gene expression during zebrafish offspring development and life-long fitness

Ada Jimenez-Gonzalez, Federico Ansaloni, Constance Nebendahl, Ghazal Alavioon, David Murray, Weronika Robak, Remo Sanges, Ferenc Müller, Simone Immler

From Jimenez-Gonzalez et al. This image is made available under a CC-BY-NC 4.0 International license.

Systematic Perturbation of Thousands of Retroviral LTRs in Mouse Embryos

Jian Yang, Lauryn Cook, Zhiyuan Chen

Identification of multiple transcription factor genes potentially involved in the development of electrosensory versus mechanosensory lateral line organs

Martin Minařík, Melinda S. Modrell, J. Andrew Gillis, Alexander S. Campbell, Isobel Fuller, Rachel Lyne, Gos Micklem, David Gela, Martin Pšenička, Clare V. H. Baker

Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF-16 translocation

Min Feng, Baizhen Gao, L. Rene Garcia, Qing Sun

Loss of G9a does not phenocopy the requirement for Prdm12 in the development of the nociceptive neuron lineage

Panagiotis Tsimpos, Simon Desiderio, Pauline Cabochette, Sadia Kricha, Eric J. Bellefroid

| Stem cells, regeneration & disease modelling

Diffusible fraction of niche BMP ligand safeguards stem-cell differentiation

Sharif M Ridwan, Samaneh Poursaeid, Emma Kristine Beard, Autumn Twillie, Muhammed Burak Bener, Matthew Antel, Ann E Cowan, Shinya Matsuda, Mayu Inaba

Tissue-scale dynamic mapping of Hematopoietic Stem Cells and supportive niche cells in the fetal liver

Patrick M Helbling, Anjali Vijaykumar, Alvaro Gomariz, Karolina A Zielinska, Thomas Zerkatje, Kathrin Loosli, Stephan Isringhausen, Takashi Nagasawa, Ingo Roeder, Markus G Manz, Tomomasa Yokomizo, Cesar Nombela-Arrieta

Stem cell proliferation and differentiation during larval metamorphosis of the model tapeworm Hymenolepis microstoma

Jimena Montagne, Matías Preza, Uriel Koziol

HIF1A contributes to the survival of aneuploid and mosaic pre-implantation embryos

Estefania Sanchez-Vasquez, Marianne E. Bronner, Magdalena Zernicka-Goetz

Tuning apico-basal polarity and junctional recycling in the hemogenic endothelium orchestrates pre-hematopoietic stem cell emergence complexity

Léa Torcq, Sara Majello, Catherine Vivier, Anne A. Schmidt

Single Cell Multi-Omics of an iPSC Model of Human Sinoatrial Node Development Reveals Genetic Determinants of Heart Rate and Arrhythmia Susceptibility

James L. Engel, Xianglong Zhang, Daniel R. Lu, Olaia F. Vila, Vanessa Arias, Jasper Lee, Christopher Hale, Yi-Hsiang Hsu, Chi-Ming Li, Roland S. Wu, Vasanth Vedantham, Yen-Sin Ang

Distinct stem-like cell populations facilitate functional regeneration of the Cladonema medusa tentacle

Sosuke Fujita, Mako Takahashi, Gaku Kumano, Erina Kuranaga, Masayuki Miura, Yu-ichiro Nakajima

Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration

Qinghao Yu, Hannah E. Walters, Giovanni Pasquini, Sumeet Pal Singh, Martina Lachnit, Catarina Oliveira, Daniel León-Periñán, Andreas Petzold, Preethi Kesavan, Cristina Subiran, Ines Garteizgogeascoa, Dunja Knapp, Anne Wagner, Andrea Bernardos, María Alfonso, Gayathri Nadar, Alwin M. Graf, Konstantin E. Troyanovskiy, Andreas Dahl, Volker Busskamp, Ramón Martínez-Máñez, Maximina H. Yun

In vitro pigmentation of human iPSC-derived retinal pigment epithelium cells does not indicate their quality for cell transplantation

Yoko Nakai-Futatsugi, Jianshi Jin, Taisaku Ogawa, Noriko Sakai, Akiko Maeda, Ken-ichi Hironaka, Masakazu Fukuda, Hiroki Danno, Yuji Tanaka, Seiji Hori, Katsuyuki Shiroguchi, Masayo Takahashi

Folate depletion alters mouse trophoblast stem cell regulation in vitro

Joanna Rakoczy, Erica D Watson

Single cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration

Laura Celotto, Fabian Rost, Anja Machate, Juliane Bläsche, Andreas Dahl, Anke Weber, Stefan Hans, Michael Brand

Single nuclei transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration

Simon Perrin, Cécile-Aurore Wotawa, Vincent Bretegnier, Marine Luka, Fanny Coulpier, Cécile Masson, Mickael Ménager, Céline Colnot

Dynein directs prophase centrosome migration to control the stem cell division axis in the developing C. elegans epidermis

Cátia Carvalho, Daniel J. Barbosa, Ricardo Celestino, Esther Zanin, Ana Xavier Carvalho, Reto Gassmann

From Carvalho et al. This image is made available under a CC-BY 4.0 International license.

iPSC-based modeling of helicase deficiency reveals impaired cell proliferation and increased apoptosis after NK cell lineage commitment

Seungmae Seo, Sagar L. Patil, Yong-Oon Ahn, Jacqueline Armetta, Everardo Hegewisch-Solloa, Micah Castillo, Nicole C. Guilz, Achchhe Patel, Barbara Corneo, Malgorzata Borowiak, Preethi Gunaratne, Emily M. Mace

Dendritic atoh1a+ cells serve as transient intermediates during zebrafish Merkel cell development and regeneration

Evan W. Craig, Erik C. Black, Camille E.A. Goo, Avery Angell Swearer, Nathaniel G. Yee, Jeffrey P. Rasmussen

The Chordate Origins of Heart Regeneration

Keaton J. Schuster, Lionel Christiaen

Biallelic variants in LARS1 induce steatosis in developing zebrafish liver via enhanced autophagy

Masanori Inoue, Wulan Apridita Sebastian, Shota Sonoda, Hiroaki Miyahara, Nobuyuki Shimizu, Hiroshi Shiraishi, Miwako Maeda, Kumiko Yanagi, Tadashi Kaname, Reiko Hanada, Toshikatsu Hanada, Kenji Ihara

Single-cell mitochondrial variant enrichment resolved clonal tracking and spatial architecture in human embryonic hematopoiesisv

Yan Xue, Yiming Chao, Xinyi Lin, Yuanhua Huang, Joshua WK Ho, Ryohichi Sugimura

HLA-Based Banking of Human Induced Pluripotent Stem Cells in Saudi Arabia

Maryam Alowaysi, Robert Lehmann, Mohammad Al-Shehri, Moayad Baadheim, Hajar Alzahrani, Doaa Aboalola, Asima Zia, Dalal Malibari, Mustafa Daghestani, Khaled Alghamdi, Ali Haneef, Dunia Jawdat, Fahad Hakami, David Gomez-Cabrero, Jesper Tegner, Khaled Alsayegh

| Plant development

Transcriptional modulation during photomorphogenesis in rice seedlings

Parul Gupta, Pankaj Jaiswal

Carotenoid metabolism negatively regulates auxin-mediated root growth

Kang Xu, Haoran Zeng, Emi Yumoto, Masashi Asahina, Ken-ichiro Hayashi, Hidehiro Fukaki, Hisashi Ito, Masaaki K. Watahiki

Single-plant-omics reveals the cascade of transcriptional changes during the vegetative-to-reproductive transition

Ethan J Redmond, James Ronald, Seth J Davis, Daphne Ezer

Evolutionarily Conserved CKI1-Mediated Two-Component Signaling is Required for Female Germline Specification in Marchantia polymorpha

Haonan Bao, Rui Sun, Megumi Iwano, Yoshihiro Yoshitake, Shiori S Aki, Masaaki Umeda, Ryuichi Nishihama, Shohei Yamaoka, Takayuki Kohchi

Cellular gibberellin dynamics govern indeterminate nodule development, morphology and function

Colleen Drapek, Nadiatul A. Radzman-Mohd, Annalisa Rizza, Katharina Schiessl, Fabio Dos Santos Barbosa, Jiangqi Wen, Giles E.D. Oldroyd, Alexander M. Jones

A Single-Nucleus Atlas of Seed-to-Seed Development in Arabidopsis

Travis A. Lee, Tatsuya Nobori, Natanella Illouz-Eliaz, Jiaying Xu, Bruce Jow, Joseph R. Nery, Joseph R. Ecker

Investigating the genetic control of plant development under speed breeding conditions

Nicola Rossi, Wayne Powell, Ian Mackay, Lee Hickey, Andreas Maurer, Klaus Pillen, Karen Halliday, Rajiv Sharma

Tip Growth Defective1 interacts with the cellulose synthase complex to regulate cellulose synthesis in Arabidopsis thaliana

Edwin R Lampugnani, Staffan Persson, Ghazanfar Abbas Khan

From Lampugnani et al. This image is made available under a CC-BY 4.0 International license.

Arabidopsis CML13 and CML14 Have Essential And Overlapping Roles In Plant Development

Kyle Symonds, Howard Teresinski, Bryan Hau, David Chiasson, Wayne A. Snedden

Leaf and shoot apical meristem transcriptomes of quinoa (Chenopodium quinoa Willd.) in response to photoperiod and plant development

Nathaly Maldonado-Taipe, Elodie Rey, Mark Tester, Christian Jung, Nazgol Emrani

Sequence characterization of T, Bip, and Phbw demonstrates the role of MYB-bHLH-WD40 complexes and temperature in common bean seed color pattern formation

Travis Parker, Tayah Bolt, Troy Williams, Ramachandra Varma Penmetsa, Mwiinga Mulube, Antonia Palkovic, Celestina Nhagupana Jochua, Maria del Mar Rubio Wilhelmi, Sassoum Lo, Gail Bornhorst, Li Tian, Kelvin Kamfwa, Sam Hokin, Andrew Farmer, Christine H. Diepenbrock, Paul Gepts

Differential mutation accumulation in plant meristematic layers

Kirk R Amundson, Mohan Prem Anand Marimuthu, Oanh Nguyen, Konsam Sarika, Isabelle J DeMarco, Angelina Phan, Isabelle M Henry, Luca Comai

From buds to shoots: Insights into grapevine development from the Witch’s Broom bud sport

Eleanore J. Ritter, Peter Cousins, Michelle Quigley, Aidan Kile, Sunil K. Kenchanmane Raju, Daniel H. Chitwood, Chad Niederhuth

LTP2 hypomorphs show genotype-by-environment interaction in early seedling traits in Arabidopsis thaliana

Cristina M Alexandre, Kerry L Bubb, Karla M Schultz, Janne Lempe, Josh T Cuperus, Christine Queitsch

Mechanotransduction in Lateral Root Initiation: A Model Integrating Growth Mechanics and Auxin Signaling

João R. D. Ramos, Blanca Jazmin Reyes-Hernández, Karen Alim, Alexis Maizel

Imprinting but not cytonuclear interactions affects parent-of-origin effect on seed size in Arabidopsis hybrids

Viviana June, Xiaoya Song, Z. Jeffrey Chen

Phosphate starvation regulates cellulose synthesis to modify root growth

Ghazanfar Abbas Khan, Arka Dutta, Allison Van de Meene, Kristian EH. Frandsen, Michael Ogden, James Whelan, Staffan Persson

DEVIL peptides control cell growth and differentiation in different developmental processes

Ana Alarcia, Amparo Primo-Capella, Elena Perpiñán, Priscilla Rossetto, Cristina Ferrándiz

From Alarcia et al. This image is made available under a CC-BY 4.0 International license.

The HOMEODOMAIN-Like protein HDL mediates chromatin organization and rewires leaf epidermal patterning

Ansar Ali, Chi Kuan, Fu-Yu Hung, Tsai-Chen Chen, Hui-Chun Lee, Shao-Li Yang, Yun-Ru Feng, Keqiang Wu, Chin-Min Kimmy Ho

Expression of cell-wall related genes is highly variable and correlates with sepal morphology

Diego A. Hartasánchez, Annamaria Kiss, Virginie Battu, Charline Soraru, Abigail Delgado-Vaquera, Florian Massinon, Marina Brasó-Vives, Corentin Mollier, Marie-Laure Martin-Magniette, Arezki Boudaoud, Françoise Monéger

| Evo-devo

Control of cell fate specification and patterning by an ancestral microRNA

Adolfo Aguilar-Cruz, Eduardo Flores-Sandoval, Ximena Gutiérrez-Ramos, Omar Oltehua- Lopez, Ana E. Dorantes-Acosta, Joshua T. Trujillo, Hirotaka Kato, Kimitsune Ishizaki, Rebecca A. Mosher, Liam Dolan, Daniel Grimanelli, Jim Haseloff, John L. Bowman, Mario A. Arteaga-Vazquez

Evolution and diversity of biomineralized columnar architecture in early Cambrian phosphatic-shelled brachiopods

Zhiliang Zhang, Zhifei Zhang, Lars E. Holmer, Timothy P. Topper, Bing Pan, Guoxiang Li

Insights into Digit Evolution from a Fate Map Study of the Forearm

JDH Oh, DDZ Saunders, L McTeir, M Jackson, JD Glover, JJ Schoenebeck, LA Lettice, MG Davey

From Oh et al. This image is made available under a CC-BY 4.0 International license.

Molecular evolution of male reproduction across species with highly divergent sperm morphology in diverse murine rodents

Emily E. K. Kopania, Gregg W. C. Thomas, Carl R. Hutter, Sebastian M. E. Mortimer, Colin M. Callahan, Emily Roycroft, Anang S. Achmadi, William G. Breed, Nathan L. Clark, Jacob A. Esselstyn, Kevin C. Rowe, Jeffrey M. Good

Genetic basis of variation in thermal developmental plasticity for Drosophila melanogaster body pigmentation

E Lafuente, D Duneau, P Beldade

Uncovering the mosaic evolution of carnivoran skeletal systems

Chris J. Law, Leslea J. Hlusko, Z. Jack Tseng

Larval brooding damselfishes and shifting body proportions: does pelagic larval swimming constrain reef fish morphology?

J.P. Lyons, K.D. Kavanagh

An amphioxus neurula stage cell atlas supports a complex scenario for the emergence of vertebrate head mesoderm

Xavier Grau-Bové, Lucie Subirana, Lydvina Meister, Anaël Soubigou, Ana Neto, Anamaria Elek, Oscar Fornas, Jose Luis Gomez-Skarmeta, Juan J Tena, Manuel Irimia, Stéphanie Bertrand, Arnau Sebé-Pedrós, Hector Escriva

Adaptive Functions of Structural Variants in Human Brain Development

Wanqiu Ding, Xiangshang Li, Jie Zhang, Mingjun Ji, Mengling Zhang, Xiaoming Zhong, Yong Cao, Xiaoge Liu, Chunqiong Li, Chunfu Xiao, Jiaxin Wang, Ting Li, Qing Yu, Fan Mo, Boya Zhang, Jianhuan Qi, Jie-Chun Yang, Juntian Qi, Lu Tian, Xinwei Xu, Qi Peng, Wei-Zhen Zhou, Zhijin Liu, Aisi Fu, Xiuqin Zhang, Jian-Jun Zhang, Yujie Sun, Baoyang Hu, Ni A. An, Li Zhang, Chuan-Yun Li

Hybridization and its impact on the ontogenetic allometry of skulls in macaques

Tsuyoshi Ito, Ryosuke Kimura, Hikaru Wakamori, Mikiko Tanaka, Ayumi Tezuka, Atsushi J. Nagano, Yuzuru Hamada, Yoshi Kawamoto

Comparative single-cell regulome reveals evolutionary innovations in neural progenitor cells during primate corticogenesis

Yuting Liu, Xin Luo, Yiming Sun, Kaimin Chen, Ting Hu, Benhui You, Jiahao Xu, Fengyun Zhang, Xiaoyu Meng, Xiang Li, Xiechao He, Cheng Li, Bing Su

Gene regulatory network that shaped the evolution of larval sensory organ in Cnidaria

Eleanor Gilbert, Jamie Craggs, Vengamanaidu Modepalli

Coevolution of larval signalling and worker response can trigger developmental caste determination in social insects

Juan Jose Lagos-Oviedo, Ido Pen, Jan Jakob Kreider

From Lagos-Oviedo et al. This image is made available under a CC-BY-NC 4.0 International license.

Cell Biology

Cerebellar granule cell migration and folia development requires Mllt11/Af1q

Marley Blommers, Danielle Stanton-Turcotte, Emily A. Witt, Mohsen Heidari, Angelo Iulianella

Tropomyosin 1 deficiency facilitates cell state transitions to enhance hemogenic endothelial cell specification during hematopoiesis

Madison B Wilken, Gennadiy Fonar, Catriana Nations, Giulia Pavani, Victor Tsao, James Garifallou, Joanna Tober, Laura Bennett, Jean Ann Maguire, Alyssa Gagne, Nkemdilim Okoli, Paul Gadue, Stella T Chou, Nancy A Speck, Deborah L French, Christopher S Thom

From Wilken et al. This image is made available under a CC-BY-NC 4.0 International license.

Rab35 is required for embryonic development and kidney and ureter homeostasis through regulation of epithelial cell junctions

Kelsey R. Clearman, Napassawon Timpratoom, Dharti Patel, Addison B. Rains, Courtney J. Haycraft, Mandy J. Croyle, Jeremy F. Reiter, Bradley K. Yoder

Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy

Yongchun Zhang, Dimitris Karagiannis, Helu Liu, Mi Lin, Yinshan Fang, Ming Jiang, Xiao Chen, Supriya Suresh, Haidi Huang, Junjun She, Feiyu Shi, Patrick Yang, Wael El-Rifai, Alexander Zaika, Anthony E. Oro, Anil K. Rustgi, Timothy C. Wang, Chao Lu, Jianwen Que

Gαi2-Mediated Regulation of Microtubules Dynamics and Rac1 Activity Orchestrates Cranial Neural Crest Cell Migration in Xenopus

Soraya Villaseca, Juan Ignacio Leal, Jossef Guajardo, Hernan Morales-Navarrete, Roberto Mayor, Marcela Torrejón

Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells

Naoki Kubo, Ryuji Uehara, Shuhei Uemura, Hiroaki Ohishi, Kenjiro Shirane, Hiroyuki Sasaki

A Cholinergic Signaling Pathway underlying Cortical Circuit Regulation of Lateral Ventricle Quiescent Neural Stem Cells

Moawiah M Naffaa, Henry H. Yin

Inhibition of the serine protease HtrA1 by SerpinE2 suggests a role for an extracellular proteolytic pathway in the control of neural crest migration

Edgar M. Pera, Josefine Nilsson-De Moura, Yuriy Pomeshchik, Laurent Roybon, Ivana Milas

An architectural role of oskar mRNA in granule assembly

Mainak Bose, Branislava Rankovic, Julia Mahamid, Anne Ephrussi

The Shot CH1 domain recognises a distinct form of F-actin during Drosophila oocyte determination

D. Nashchekin, I. Squires, A. Prokop, D. St Johnston

From Nashchekin et al. This image is made available under a CC-BY 4.0 International license.

Modelling

Morphogen gradients can convey position and time in growing tissues

Roman Vetter, Dagmar Iber

A dynamic Hedgehog gradient orients tracheal cartilage rings

Evan P. Kingsley, Darcy Mishkind, Tom W. Hiscock, Clifford J. Tabin

Plasticity-led evolution as an intrinsic property of developmental gene regulatory networks

Eden Tian Hwa Ng, Akira R. Kinjo

Mechanistic Regulation of Planarian Shape During Growth and Degrowth

Jason M. Ko, Waverly Reginato, Daniel Lobo

Tools & Resources

A Meta-Atlas of the Developing Human Cortex Identifies Modules Driving Cell Subtype Specification

Patricia R Nano, Elisa Fazzari, Daria Azizad, Claudia V Nguyen, Sean Wang, Ryan L Kan, Brittney Wick, Maximilian Haeussler, Aparna Bhaduri

Single-cell epigenomic reconstruction of developmental trajectories in human neural organoid systems from pluripotency

Fides Zenk, Jonas Simon Fleck, Sophie Martina Johanna Jansen, Bijan Kashanian, Beneditk Eisinger, Malgorzata Santel, Jean Samuel Dupre, Gray Camp, Barbara Treutlein

Mapping the developmental potential of mouse inner ear organoids at single-cell resolution

Joerg Waldhaus, Linghua Jiang, Liqian Liu, Jie Liu, Robert Keith Duncan

Germ cells do not progress through spermatogenesis in the infertile zebrafish testis

Andrea L. Sposato, Darren R. Llewellyn, Jenna M. Weber, Hailey L. Hollins, Madison N. Schrock, Jeffrey A. Farrell, James A. Gagnon

A single-cell atlas of pig gastrulation as a resource for comparative embryology

Luke Simpson, Andrew Strange, Doris Klisch, Sophie Kraunsoe, Takuya Azami, Daniel Goszczynski, Triet Le, Benjamin Planells, Nadine Holmes, Fei Sang, Sonal Henson, Matthew Loose, Jennifer Nichols, Ramiro Alberio

Single-cell transcription mapping of murine and human mammary organoids responses to female hormones

Jenelyz Ruiz-Ortiz, Steven M. Lewis, Michael F. Ciccone, Deeptiman Chatterjee, Samantha Henry, Adam Siepel, Camila O. Dos Santos

Transcriptome analysis reveals temporally regulated genetic networks during Drosophila border cell collective migration

Emily Burghardt, Jessica Rakijas, Antariksh Tyagi, Pralay Majumder, Bradley J.S.C. Olson, Jocelyn A. McDonald

A Window into Mammalian Basement Membrane Development: Insights from the mTurq2-Col4a1 Mouse Model

Rebecca A. Jones, Brandon Trejo, Parijat Sil, Katherine A. Little, H. Amalia Pasolli, Bradley Joyce, Eszter Posfai, Danelle Devenport

From Jones et al. This image is made available under a CC-BY 4.0 International license.

Root Walker: an automated pipeline for large scale quantification of early root growth responses at high spatial and temporal resolution

Platre Matthieu Pierre, Mehta Preyanka, Halvorson Zachary, Ling Zhang, Brent Lukas, Gleason F. Matias, Faizi Kian, Goulding Callum, Busch Wolfgang

Research practice & education

An effective C. elegans CRISPR training module for high school and undergraduate summer research experiences in molecular biology

Carmen Herrera Sandoval, Christopher Borchers, Scott Takeo Aoki

Development of an undergraduate cell biology laboratory to assess pigmentation and cell size in a zebrafish model of uveal melanoma

Andrea M. Henle

Controlled experiment finds no detectable citation bump from Twitter promotion

Trevor A. Branch, Isabelle M. Cȏté, Solomon R. David, Joshua A. Drew, Michelle LaRue, Melissa C. Márquez, E. Chris M. Parsons, D. Rabaiotti, David Shiffman, David A. Steen, Alexander L. Wild

Biomedical researchers’ perspectives on the reproducibility of research: a cross-sectional international survey

Kelly D. Cobey, Sanam Ebrahimzadeh, Matthew J. Page, Robert T. Thibault, Phi-Yen Nguyen, Farah Abu-Dalfa, David Moher

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Most-read posts in May

Do you have any news to share?

Our ‘Developing news’ posts celebrate the various achievements of the people in the developmental and stem cell biology community. Let us know if you would like to share some news.