the community site for and by developmental biologists
the community site for and by developmental biologists
Posted by nicolasrivron on June 27th, 2018
In our recently published paper1, we showed that mouse stem cells self-organize into blastocyst-like structures, that we termed blastoids. Because blastoids can be generated in large numbers, can be finely manipulated, and implant in utero, they are a powerful tool to investigate the principles of pre- and post-implantation development. Here is the backstory of our[…]
Posted by nicolasrivron on June 12th, 2018
Hubrecht Institute for developmental biology and stem cell research. MERLN Institute for technology-driven regenerative medicine. Laboratory for stem cell-based development. 2 years The Netherlands A two-year postdoctoral position is available at the laboratory for stem cell-based development headed by Nicolas Rivron. The laboratory is located at the MERLN institute for technology-driven regenerative medicine (Maastricht)[…]
Posted by the Node Interviews on February 15th, 2017
Embryonic stem cells express genes necessary for self-renewal, and also ‘prime’ lineage-specific genes which stay silent until differentiation; the molecular players and pathways that govern the timely gene expression are still being delineated. Today’s paper comes from the most recent issue of Development and reveals a role for the histone demethylase Jmjd2c in gene activation in stem cell[…]
Posted by aprilcraft on October 10th, 2016
We are looking for an enthusiastic and highly motivated Staff Scientist or experienced Research Assistant/Technician to join the stem cell and regenerative medicine-based laboratory of Dr. April Craft, within the department of Orthopaedic Research at Boston Children’s Hospital and Harvard Medical School. Our lab studies the development of musculoskeletal tissues, primarily articular cartilage, using human[…]
Posted by aprilcraft on October 10th, 2016
We are looking for an outstanding, highly motivated postdoctoral fellow to join our innovative young department in the stem cell and regenerative medicine-focused laboratory of Dr. April Craft, Assistant Professor of Orthopaedic Surgery at Boston Children’s Hospital and Harvard Medical School. Our lab studies the development of musculoskeletal tissues, primarily cartilage, using human and mouse[…]
Posted by Anestis Tsakiridis on October 6th, 2016
We are currently seeking an independent and motivated scientist to join the research group led by Dr Anestis Tsakiridis (https://www.sheffield.ac.uk/cscb/tsakiridis). His work focuses on dissecting the molecular basis of cell fate decisions in the developing embryo and aims to exploit this knowledge for disease-modelling and regenerative medicine applications. The group is particularly interested in the biology of neuromesodermal progenitors[…]
Posted by Christele Gonneau on April 1st, 2015
Mouse embryonic stem cells (mESCs) are by definition cells that can self-renew (make identical copies of themselves) and specialize into any cell type of the body. Since their discovery, scientists have used them to produce various specialized cell types in culture but also to produce transgenic mouse lines. When injected into a mouse early embryo,[…]
Posted by Christele Gonneau on January 22nd, 2015
Growing organs in vitro is one of the ultimate dreams of any stem cell biologist. As such, it seems obvious that some of these organs will need to be grown in 3D. This is why stem cell 3D culture systems are very fashionable among scientists. They are increasingly successful and a fair amount[…]
Posted by Andrea Aguilar on October 21st, 2014
The Ethics Session at the Company of Biologists “From Stem Cells to Human Development” workshop Last September the Company Of Biologists organized an exciting three-day dive into the biology of human stem cells and their use to study human development and regeneration (look out for the full meeting report in Development, coming soon, and Katherine[…]
Posted by Aryeh Warmflash on September 24th, 2014
Waddington, whose writings on the epigenetic landscape continue to influence developmental biology to this day, called the developing embryo “the most intriguing object that nature has to offer”(Waddington, 1966). The mechanisms of pattern formation and morphogenesis have fascinated biologists for centuries. One question that is difficult to answer is what are the minimal requirements for[…]
