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Nuclear sponges in embryonic stem cells

Posted by on June 17th, 2014

Once upon a time, physicists got curious about the cytoskeleton. They characterised the cytoskeleton – using tools of soft matter, statistical and polymer physics – as a mesoscale material whose physical properties govern its dynamics. They showed that the cytoskeleton is an interconnected scaffold that, depending on the time scale, can behave like a shape-morphing[…]

Stone Soup Eyes

Posted by on April 16th, 2014

Another installment from the Developmental Neurobiology Students at Reed College. Hope you enjoy! It’s not often that you get to recount the classic tale of Stone Soup when thinking about developmental biology, but that’s exactly what we did when discussing an almost classic 2011 Nature paper from Yoshiki Sasai’s group. In the story, a grumpy[…]

Decoding reprogramming

Posted by on February 28th, 2014

When it comes to stem cell biology, there have been very few topics as fascinating and popular as cell reprogramming, the most famous reprogramming experiment being the one of Dolly the sheep. In stem cell biology, reprogramming refers to the concept of taking a fully specialized cell in the body and manipulating it in order[…]

PhD opportunity available in Dundee

Posted by on January 17th, 2013

O-GlcNAc signalling during embryonic stem cell differentiation My lab is studying the signalling mechanisms governing the onset of differentiation of pluripotent embryonic stem (ES) cells. Work from this and other labs (e.g. 1, 2) has revealed a critical role for autocrine FGF signalling and consequent sustained phosphorylation of the kinase Erk during the differentiation process.[…]

iPS cell culture scientist in the Scottish Centre for Regenerative Medicine

Posted by on July 13th, 2012

Job Summary: Due to the set up of a new induced pluripotent stem (iPS) cell facility managed by Roslin Cells Ltd, we are looking to employ two Cell Culture Scientists to work within a small team engaged in the generation of new research grade and clinical grade cell lines for academic and commercial customers. Job Description: The post[…]

Differences between mammals begin early in development

Posted by on March 8th, 2012

The progress of stem cell research depends on the ability to grow stem cells in culture.  Embryonic stem (ES) cells from some organisms, such as humans, have proven difficult to culture.  While it is known that there are differences in early development between even closely-related species, understanding where these differences begin will help biologists understand[…]

Embryonic stem cells – keeping a clean slate

Posted by on August 15th, 2011

Do your ears perk up when you hear about embryonic stem cells?  We all have heard and/or participated in the controversy surrounding the use of them, yet there is no debate over their biological importance and medical potential.  A paper in Journal of Cell Science describes the newly-indentified role for Banf1 in ESC self-renewal. Embryonic[…]

Embryonic stem cell origin — food for thought

Posted by on February 9th, 2011

What I love about developmental biology is the collaborative nature of the field.   The vast majority of biologists feel that by sharing ideas, data, and reagents, we can learn more than if we were all to work alone with blinders on our heads.  A recent paper in Development puts forth a hypothesis about embryonic stem[…]