the community site for and by developmental biologists
the community site for and by developmental biologists
Posted by the Node Interviews on January 29th, 2020
This interview, the 74th in our series, was recently published in Development. Dysregulated activity of cell surface proteolytic enzymes has a wide range of developmental and pathological consequences, but the underlying mechanisms are often poorly understood. A new Development paper uses mice to model a severe inherited form of enteropathy and the role of the serine protease matriptase[…]
Posted by the Node on October 1st, 2018
From the MRC Weatherall Institute of Molecular Medicine blog. Stem cell turnover and tissue maintenance is a stochastic process. This means that a randomly occurring mutation has an unknown chance of becoming fixed and spreading within a tissue. Clonal mutations have been observed in apparently healthy tissue, increase in frequency with age and –[…]
Posted by Michal Shoshkes-Carmel on June 5th, 2018
The story behind FOXL1+ telocytes You can find our recently published Nature paper here Our story began two decades ago when my mentor, Klaus H. Kaestner, identified and cloned the transcription factor FOXL1, as being expressed in the mesenchyme of the mouse fetal gut (Kaestner et al. 1997). The position of FOXL1+ mesenchymal cells[…]
Posted by Jun Chen on March 6th, 2018
Jun Chen National Institute of Biological Sciences, Beijing A discussion of our recent paper: Chen J, Xu N, Wang C, Huang P, Huang H, Jin Z, Yu Z, Cai T, Jiao R, Xi R. Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells. Nat Cell Biol. 2018[…]
Posted by Rob Fordham on December 18th, 2013
My name is Rob Fordham and I’ve just finished my PhD at the Wellcome Trust/MRC Cambridge Stem Cell Institute, University of Cambridge, supervised by Dr Kim Jensen (now Associate Professor at the Biotech Research and Innovation Center (BRIC), University of Copenhagen), and Professor Roger Pedersen.* During my PhD I was fascinated with intestinal development- and[…]
