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Postdoctoral Research Fellow position in stem cells and intestinal regeneration- Patel lab U. of Bristol

Posted by on September 6th, 2020

We are looking for a passionate, intellectually curious and creative postdoctoral research fellow with a strong interest in tissue maintenance, regeneration and ageing to join our lab.   The Patel lab at the School of Cellular and Molecular Medicine, University of Bristol studies how tissues regenerate themselves after damage and how they maintain themselves over[…]

The people behind the papers – Roman Szabo and Thomas Bugge

Posted by on January 29th, 2020

This interview, the 74th in our series, was recently published in Development.  Dysregulated activity of cell surface proteolytic enzymes has a wide range of developmental and pathological consequences, but the underlying mechanisms are often poorly understood. A new Development paper uses mice to model a severe inherited form of enteropathy and the role of the serine protease matriptase[…]

Clone Wars: A New Model

Posted by on October 1st, 2018

From the MRC Weatherall Institute of Molecular Medicine blog.   Stem cell turnover and tissue maintenance is a stochastic process. This means that a randomly occurring mutation has an unknown chance of becoming fixed and spreading within a tissue. Clonal mutations have been observed in apparently healthy tissue, increase in frequency with age and –[…]

Rare is Everywhere

Posted by on June 5th, 2018

The story behind FOXL1+ telocytes You can find our recently published Nature paper here   Our story began two decades ago when my mentor, Klaus H. Kaestner, identified and cloned the transcription factor FOXL1, as being expressed in the mesenchyme of the mouse fetal gut (Kaestner et al. 1997). The position of FOXL1+ mesenchymal cells[…]

Stem cell fate choice: determined in an instant

Posted by on March 6th, 2018

Jun Chen National Institute of Biological Sciences, Beijing A discussion of our recent paper: Chen J, Xu N, Wang C, Huang P, Huang H, Jin Z, Yu Z, Cai T, Jiao R, Xi R. Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells. Nat Cell Biol. 2018[…]

Intestinal stem cells- from a foetal development perspective

Posted by on December 18th, 2013

My name is Rob Fordham and I’ve just finished my PhD at the Wellcome Trust/MRC Cambridge Stem Cell Institute, University of Cambridge, supervised by Dr Kim Jensen (now Associate Professor at the Biotech Research and Innovation Center (BRIC), University of Copenhagen), and Professor Roger Pedersen.* During my PhD I was fascinated with intestinal development- and[…]