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The evolution of nerves: understanding the roots of neurodegeneration

Posted by on October 27th, 2020

Application Deadline: 22 January 2021 Supervisors: Andreas Prokop, Matthew Ronshaugen, Karl Kadler Project details How to apply To develop remedial strategies for neurodegeneration in age and disease, we need to improve our understanding of the cell biology of neurons – in particular their axons. Axons are the cable-like, up-to-meter long processes of neurons that wire[…]

Adult Neurogenesis 2018: Highlights -By Zubair Ahmed Nizamudeen

Posted by on June 29th, 2018

4WH Neurogenesis: What Where Why When and How? Neurogenesis is understood as the process by which neural stem cells (NSCs) produce new neurons. In the adult mammalian brain, this process is known to persist in two restricted locations- the dentate gyrus (DG) region of the hippocampus (see figure below) and the lateral walls of the[…]

Manchester PhD position on neuronal development, ageing & degeneration

Posted by on October 17th, 2017

The University of Manchester, 2018/19 BBSRC DTP PhD Project Understanding tubulin regulation during neuronal development, ageing and degeneration Axons are slender, up-to-a-meter long, cable-like extensions of neurons which form the nerves and nerve tracts that wire our bodies and brain. These delicate cellular structures have to be maintained for an organism’s life time and are[…]

Want to attend Adult Neurogenesis 2015? Go as the official meeting reporter…

Posted by on January 12th, 2015

Adult Neurogenesis: Evolution, Regulation and Function May 6-8, 2015 – Dresden, Germany Website: 2015 is the 50th anniversary of Joseph Altman’s landmark discovery of adult neurogenesis. To celebrate, the fourth conference in Abcam’s Adult Neurogenesis meeting series this meeting will put the developmental process of adult neurogenesis and its regulation into the wider context[…]

Seeing a future for retinal regeneration

Posted by on June 14th, 2013

Regeneration is a superpower not just reserved for superheroes—salamanders and newts are able to regenerate lost limbs and tails, and fish can regenerate new retinal neurons after injury to the eye.  Mammals have limited ability to regenerate retinal neurons, but a recent paper in Development finds that a single transcription factor may be able to[…]

Hope for Huntington’s

Posted by on January 14th, 2013

Every time a biologist drives pluripotent cells to differentiate into a specialized cell type, patients of all sorts of diseases, disorders, and injuries allow their hope to grow.  A research group recently reported how to drive differentiation of human pluripotent stem cells into medium-sized spiny neurons, the neurons that are some of the first to[…]

Remember this: Sox1 marks neural stem cells in the hippocampus

Posted by on November 13th, 2012

Most folks think that our brains don’t produce any more neurons after we’re born, but thankfully they do!  A small subset of stem cells within the hippocampus gives rise to neurons in a region of the brain believed to be associated with learning and memory, and a recent paper describes the self-renewal properties and potential[…]

A stem cell needs REST

Posted by on August 14th, 2012

Decisions, decisions.  Stem cells face the task to self-renew or differentiate, a decision made out of the combination and coordination of numerous regulators.  With the activation or suppression of transcriptional activators and the activation or suppression of repressors, it’s easy to see how understanding this process is anything BUT easy.  Today’s images are from a[…]

Wrap your brain around precursor cells

Posted by on February 10th, 2012

A fully differentiated cell took a fascinating journey to become its present self.  For every cell, a precursor cell existed that gave rise to it.  And for every precursor cell, a stem cell existed that gave rise to it.  Understanding precursor cells is an important part in understanding stem cell biology.  Today’s image is from[…]

Schwann cells and N-WASp: it always comes down to actin

Posted by on April 22nd, 2011

Axons have such important jobs to do that they require their own support staff.  Schwann cells are responsible for ensheathing axons of the peripheral nervous system with myelin, which allows rapid conduction of action potentials.  The process by which Schwann cells do this was understood to involve cytoskeletal regulators, and a recent paper in Development[…]