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From mysterious cysts to CSF-in-a-dish

Posted by on September 21st, 2020

Our brain is immersed in a clear, colourless, nutrient-rich fluid called the cerebrospinal fluid (CSF), which provides mechanical support to the brain and helps to circulate important molecules for brain development and function. Within the interconnected cavities of our brain, the CSF flows in and out constantly. The CSF is actively produced by the choroid[…]

Two positions open in neuroscience lab at The Crick

Posted by on September 4th, 2020

There are two open positions in my lab. We are the Neural circuits and Evolution lab at The Francis Crick Institute in London (https://prietogodinolab.org/). The  lab  employs  a  multidisciplinary  approach  to  understand  how  neural  circuits function and evolve, combining techniques that range from in vivo calcium imaging, electrophysiology, electron microscopy circuit tracing, molecular biology, single-cell RNA[…]

Retracting sheaths and words

Posted by on July 17th, 2020

My mentor, Bruce Appel, emphasizes the importance of communicating science clearly and precisely. Consequently, I have watched my peers and myself deliver ever-improving talks, posters, and manuscripts during our time in the lab. I think that many people in science appreciate that clear communication is essential for others to be able to interpret findings and[…]

The people behind the papers – Charles Sheehan, John McMahon and Debby Silver

Posted by on May 27th, 2020

This interview, the 76th in our series, was published in Development earlier this year.  Interneurons are crucial to cortical function and their dysregulation has been implicated in various neurological pathologies, yet how they are generated during development is still poorly understood. A new paper in Development investigates interneuron neurogenesis in the mouse embryo and its[…]

The birth of vision

Posted by on September 9th, 2019

By decoding the genetic mechanisms that control the neurons of the visual system, researchers at UNIGE are unveiling the first steps in the construction of vision, paving the way for regenerative eye medicine. A Press Release from the University of Geneva.   How is the retina formed? And how do neurons differentiate to become individual[…]

Turning back the clock of neural progenitor cells: a simple recipe to generate de novo retinal ganglion cells

Posted by on August 12th, 2019

Press release for a new Development paper on reprogramming in the retina. Scientists at the Federal University of Rio de Janeiro, Brazil, in collaboration with the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, discovered that a single transcription factor drives retinal progenitor cells to reacquire the potency to generate Retinal ganglion cells. The[…]

Adult Neurogenesis 2018: Highlights -By Zubair Ahmed Nizamudeen

Posted by on June 29th, 2018

4WH Neurogenesis: What Where Why When and How? Neurogenesis is understood as the process by which neural stem cells (NSCs) produce new neurons. In the adult mammalian brain, this process is known to persist in two restricted locations- the dentate gyrus (DG) region of the hippocampus (see figure below) and the lateral walls of the[…]

Free webinar | Single-cell RNA-seq and cell heterogeneity in the central nervous system

Posted by on August 17th, 2016

Register here: http://bit.ly/single_cell_rna_seq_webinar  Interested in understanding RNA-seq and its application to the study of oligodendrocyte heterogeneity? Join Dr Gonçalo Castelo-Branco and Dr Amit Zeisel, of the the Department of Medical Biochemistry and Biophysicsat the Karolinska Institutet, as they discuss the latest developments in single cell RNA-seq. Topics covered will include Technology development, applications, and challenges Investigation of[…]

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Posted by on October 23rd, 2015

Dimitri Perrin3, Shimpei I. Kubota1,2, Kazuki Tainaka1,2 & Hiroki R. Ueda1,2,4* 1Department of Systems Pharmacology, The University of Tokyo, Tokyo, Japan. 2CREST, Japan Science and Technology Agency, Saitama, Japan. 3School of Electrical Engineering and Computer Science, Science and Engineering Faculty, Queensland University of Technology, Brisbane, Australia. 4Laboratory for Synthetic Biology, RIKEN Quantitative Biology Center, Osaka,[…]

Want to attend Adult Neurogenesis 2015? Go as the official meeting reporter…

Posted by on January 12th, 2015

Adult Neurogenesis: Evolution, Regulation and Function May 6-8, 2015 – Dresden, Germany Website: http://www.abcam.com/AdultNeurogenesis2015 2015 is the 50th anniversary of Joseph Altman’s landmark discovery of adult neurogenesis. To celebrate, the fourth conference in Abcam’s Adult Neurogenesis meeting series this meeting will put the developmental process of adult neurogenesis and its regulation into the wider context[…]