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Displaying posts with the tag: the-people-behind-the-papers [Clear Filter]

The people behind the papers – George Britton and Aryeh Warmflash

Posted by on November 15th, 2019

This interview, the 71st in our series, was recently published in Development.  Our understanding of many fundamental aspects of early human development is still in its infancy, but a promising avenue for research uses advanced in vitro culturing techniques. For instance, confining human embryonic stem cells to micropatterned substrates and directing differentiation with signalling molecules has proved a powerful[…]

The people behind the papers – Mingxi Deng and Yan Yan

Posted by on November 7th, 2019

This interview, the 70th in our series, was recently published in Development.  Drosophila wing discs are epithelial sac-like organs and a powerful model for investigating the link between proliferation and patterning. Of particular interest is the question of how single cells in the disc integrate information regarding position and growth control, as morphogens that pattern an axis can[…]

The people behind the papers – Qiang Zhu, Marçal Gallemí and Eva Benková

Posted by on October 10th, 2019

This interview, the 69th in our series, was recently published in Development.  The apical hook is a transient structure that functions to protect the vulnerable apical meristem from damage when the seedling penetrates the soil. Although some of the molecular players regulating its development have been identified, many aspects have remained opaque, including how an early auxin[…]

The people behind the papers – Maurício Rocha-Martins and Mariana Silveira

Posted by on September 12th, 2019

This interview, the 68th in our series, was recently published in Development. See also the Press Release associated with the paper and also Brazilian newspaper Folha’s piece on the work  Retinal ganglion cells connect the retina to the brain, and their degeneration underlies glaucoma, which is the leading cause of irreversible blindness in humans and currently untreatable.[…]

The people behind the papers – Shai Eyal and Elazar Zelzer

Posted by on August 13th, 2019

This interview, the 67th in our series, was recently published in Development Most bones in the vertebrate skeleton are made in the same way – endochondrial ossification – yet they display a variety of shapes and sizes. The question of how these unique bone morphologies, including the superstructures that protrude from their surfaces, arise during development is[…]

The people behind the papers – Eduardo Leyva-Díaz and Oliver Hobert

Posted by on July 9th, 2019

This interview, the 66th in our series, was recently published in Development Transcriptional autoregulation occurs when transcription factors bind their own cis-regulatory sequences, ensuring their own continuous expression along with expression of other targets. During development, continued expression of identity-specifying transcription factors can be achieved by autoregulation, but until now formal evidence for a developmental requirement of autoregulation[…]

The people behind the papers – Amsha Proag and Magali Suzanne

Posted by on June 24th, 2019

This interview, the 65th in our series, was recently published in Development During development, mechanical forces sculpt tissues into myriad forms. Actomyosin contractility generated within the cell has an increasingly appreciated role in this process, but how tissue forces relate to the physical properties of the extracellular matrix is still poorly understood, particularly at longer time scales[…]

The people behind the papers – Masanori Abe and Reiko Kuroda

Posted by on June 19th, 2019

This interview, the 64th in our series, was recently published in Development One of the most obvious examples of left-right asymmetry in animal bodies comes from snails: in most species or strains, the shells coil dextrally, but some coil sinistrally. The control of coiling is genetic and begins in the early embryo. Previous work has implicated the[…]

The people behind the papers – Heidi Connahs, Sham Tlili, Timothy Saunders and Antónia Monteiro

Posted by on May 28th, 2019

This interview, the 63rd in our series, was recently published in Development Butterfly eyespots are striking examples of animal patterning, but their developmental origins are still relatively poorly understood. A new paper in Development– the result of a collaboration between two Singapore-based labs – now combines CRISPR-Cas9 gene targeting with theoretical modelling to address the role of the[…]

The people behind the papers – Li-Juan Duan and Guo-Hua Fong

Posted by on May 23rd, 2019

This interview, the 62nd in our series, was recently published in Development Vascular development critically involves pruning, which helps to remodel an immature network containing excess microvessels into a mature and functioning one. The mechanisms of vascular remodelling and the relationship between the endothelial cells and the other cell types with which they are closely associated are,[…]