the community site for and by developmental biologists

In vivo profiling of chromatin accessibility with CATaDa

Posted by on March 13th, 2018

The following post is an introduction into the technnique described in our recent paper: Aughey, G.N., et al., CATaDa reveals global remodelling of chromatin accessibility during stem cell differentiation in vivo. Elife, 2018. 7.   Attempting to understand the biology of a complex organ, like the brain, comes with an array of technical challenges. Those[…]

Post-Doc Positions in Cell Biology/Neurosciences

Posted by on March 13th, 2018

  We are currently seeking applications from post-doctoral candidates (LabEx-funded positions). Project: Christophe Heinrich “Cellular Reprogramming and Brain Repair” was recently awarded a LabEx Attraction Package at SBRI. Our group focuses on direct lineage reprogramming of somatic cells into induced neurons as a novel cell-based therapy for brain repair. We previously showed that glial cells[…]

Manipulating the Mouse Embryo: Yesterday, today, and tomorrow… Symposium in honor of Professor Brigid Hogan

Posted by on March 13th, 2018

Last Friday March 9, a research symposium was held at Duke University in Durham, North Carolina to honor the career and retirement of Professor Brigid Hogan, Chair of the Department of Cell Biology (Hogan Lab Webpage: Current and former Hogan Lab members, colleagues, and friends came from across America, Japan, and the United Kingdom[…]

The people behind the papers – You Wu & Mineko Kengaku

Posted by on March 12th, 2018

Neuronal migration is critical for mammalian brain development. In many migrating neurons, the nucleus translocates from the trailing to the leading edge of the cell in a manner dependent on the actin and microtubule cytoskeletons, but how these cytoskeletons interact and their relative contribution to the forces that move the nucleus has remained unclear. This[…]

The Curious Case of Protocadherin 19 Epilepsy

Posted by on March 12th, 2018

Daniel Pederick & Paul Thomas Comment on our paper: Pederick, et al. 2018. Abnormal Cell Sorting Underlies the Unique X-Linked Inheritance of PCDH19 Epilepsy. Neuron 97 (1).   Here we discuss the curious case of female-restricted epilepsy, an unusual disorder caused by mutations in the Protocadherin 19 (PCDH19) gene. How changes in this cell adhesion[…]

Principal Investigator positions in Cell & Developmental Biology, University of Dundee

Posted by on March 9th, 2018

Applications are sought from established as well as career development researchers with interests in nervous system and/or human development, including stem cells and organoid approaches. We are also seeking cell biologists with interests in signalling, trafficking and cell adhesion.   Applicants will be expected to be competitive for personal fellowships and/or programme level grant support[…]

Group Leader in Animal Development, Evolution and Physiology (Lyon, France)

Posted by on March 8th, 2018

The Institut de Génomique Fonctionnelle de Lyon (IGFL) has an opening for a new independent group leader. The IGFL has a unique scientific profile and fosters an outstanding international environment. Teams address basic research questions at the interfaces of evolution, physiology and development using functional genomics, bioinformatics, genetics and comparative approaches. The IGFL has a[…]

Team work, good science

Posted by on March 8th, 2018

You can find our recently published eLife paper here.   At the Euro-Evo-Devo meeting in Lisbao I saw a talk by Sylvie Rétaux and became hooked by a blind and unpigmented cavefish: the evo-devo model Astyanax mexicanus. I then had the chance to join Sylvie’s group in Gif-sur-Yvette (France) in 2013, for a post-doc. Four[…]

Funded places for early-career researchers at a human brain development & evolution workshop

Posted by on March 8th, 2018

This summer, the Company of Biologists, the not-for-profit publisher of Development, is running a Workshop on ‘Development and evolution of the human neocortex‘, organised by Victor Borrell, Wieland Huttner and Arnold Kriegstein. The Company of Biologists Workshops provide leading experts and early career scientists from a diverse range of scientific backgrounds with a stimulating environment for the cross-fertilisation[…]

Reviews Editor for the journal Development

Posted by on March 6th, 2018

We are currently seeking applications for the role of Reviews Editor for the journal Development, our flagship journal for the developmental biology and stem cell community. This is a permanent, full-time position. Joining an experienced and successful team, this is an exciting opportunity to make a significant contribution to one of the major journals in[…]