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Transposons in Embryo Space – TRACER maps in EMAGE

Posted by on February 9th, 2017

A recent publication in Developmental Biology by (Armit et al., 2017) describes how the TRACER dataset can be spatially compared with in situ hybridisation gene expression profiles.   The TRACER dataset of transposon-associated regulatory sensors (Chen et al., 2013) utilises Sleeping Beauty lacZ transposons that have been randomly integrated into the mouse genome Hundreds of[…]

Lifemap: a zoomable interface for exploring the entire Tree of Life

Posted by on January 30th, 2017

“Nothing in biology makes sense except in the light of evolution” (Dobzansky, 1973). Our knowledge of the evolutionary relationships between all known organisms, the so-called Tree of Life (ToL), is crucial in all fields of biology. Many researchers in evolutionary biology are working on improving the quality and the comprehensiveness of this ToL. This implies[…]

BSDB Gurdon Summer Studentship Report (8)

Posted by on January 24th, 2017

Established  by the British Society for Developmental Biology (BSDB) in 2014, the Gurdon/The Company of Biologists Summer Studentship scheme provides financial support to allow highly motivated undergraduate students an opportunity to engage in practical research during their summer vacation. Each year, ten successful applicants spend eight weeks in the research laboratories of their choices, and the[…]

The home of the implanting embryo: A 3D perspective

Posted by on January 5th, 2017

Comment on “Insights from imaging the implanting embryo and the uterine environment in three dimensions”, Arora et al, Development 143(24):4749-4754 (2016).   More than 2000 years ago, Hippocrates (460-377BC) and Aristotle (384-322BC) described the human uterus as a series of chambers with a lining of tentacles or suckers. They believed that blood vessels connected the breast[…]

LabCIRS – Learning from mistakes

Posted by on December 13th, 2016

Biomedical research is experiencing what has been termed a ‘reproducibility crisis’. There is much talk about how we can improve the rigor and robustness of our research to increase its value and predictiveness. Many remedies are being discussed, such as increasing statistical power, reducing bias by improving internal validity, fostering transparency by open data policies,[…]

New phenotype dataset available for embryonic-lethal mouse knockouts

Posted by on December 1st, 2016

    This post originally appeared on Annotations, the DMDD blog.   New image and phenotype data for embryos and placentas from embryonic lethal knockout mouse lines has been made available on the DMDD website today. The knockout data includes the ciliary gene Rpgrip1l as well as Atg16l1, a gene encoding a protein that forms[…]

The 3D atlas of human development

Posted by on November 28th, 2016

“It’s fair to say that we currently know more about the moon than about our own embryonic development. The current textbooks all show the same kind of images based on a few embryonic specimens from the 1930s. Some of those are not even human embryos. New version of these books keep using those images, often[…]

eLearning at eMouseAtlas

Posted by on November 24th, 2016

A new eLearning resource that provides short and interactive vignettes in embryo (primarily vertebrate) development, from gametogenesis through to organogenesis, is available from the eMouseAtlas1,2 website ( The current eLearning content are the tutorials produced by Professor José García Monterde of the University of Córdoba, and the presentation from collaboration between Professor Monterde and the[…]

New data reveals gene expression during mouse embryo development

Posted by on September 29th, 2016

This article was originally posted on the DMDD website Knowing the ‘normal’ expression of genes during embryo development is key to understanding the differences that occur due to genetic mutations. As part of work to understand the underlying transcriptional processes for developing embryos from knockout mouse lines, DMDD has now released a gene expression[…]

Exciting news on neural stem cell niches: stunning research from Fiona Doetsch’s lab

Posted by on August 26th, 2016 Sense & Sensibility: niche signals regulate neural stem cells in an age-dependent manner paper feature by Thomas Schwarz-Romond Tissue specific stem cell niches provide lifelong support for adult stem cells. The cell-biological dissection of (adult neural) stem cell – niche interactions uncovered unexpected regulatory functions. These new results imply that stem cell niches actively[…]