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BSDB Gurdon Summer Studentship Report (8)

Posted by on January 24th, 2017

Established  by the British Society for Developmental Biology (BSDB) in 2014, the Gurdon/The Company of Biologists Summer Studentship scheme provides financial support to allow highly motivated undergraduate students an opportunity to engage in practical research during their summer vacation. Each year, ten successful applicants spend eight weeks in the research laboratories of their choices, and the[…]

The home of the implanting embryo: A 3D perspective

Posted by on January 5th, 2017

Comment on “Insights from imaging the implanting embryo and the uterine environment in three dimensions”, Arora et al, Development 143(24):4749-4754 (2016).   More than 2000 years ago, Hippocrates (460-377BC) and Aristotle (384-322BC) described the human uterus as a series of chambers with a lining of tentacles or suckers. They believed that blood vessels connected the breast[…]

LabCIRS – Learning from mistakes

Posted by on December 13th, 2016

Biomedical research is experiencing what has been termed a ‘reproducibility crisis’. There is much talk about how we can improve the rigor and robustness of our research to increase its value and predictiveness. Many remedies are being discussed, such as increasing statistical power, reducing bias by improving internal validity, fostering transparency by open data policies,[…]

New phenotype dataset available for embryonic-lethal mouse knockouts

Posted by on December 1st, 2016

    This post originally appeared on Annotations, the DMDD blog.   New image and phenotype data for embryos and placentas from embryonic lethal knockout mouse lines has been made available on the DMDD website today. The knockout data includes the ciliary gene Rpgrip1l as well as Atg16l1, a gene encoding a protein that forms[…]

Advocacy for Developmental Biology

Posted by on November 30th, 2016

To promote Developmental Biology, we should have our elevator pitches ready at all times – whenever there is an opportunity to talk about our discipline – be it to the public, students, fellow scientists or policy makers. This is a first attempt at providing a concise rationale and ideas that can be woven into such[…]

The 3D atlas of human development

Posted by on November 28th, 2016

“It’s fair to say that we currently know more about the moon than about our own embryonic development. The current textbooks all show the same kind of images based on a few embryonic specimens from the 1930s. Some of those are not even human embryos. New version of these books keep using those images, often[…]

eLearning at eMouseAtlas

Posted by on November 24th, 2016

A new eLearning resource that provides short and interactive vignettes in embryo (primarily vertebrate) development, from gametogenesis through to organogenesis, is available from the eMouseAtlas1,2 website (www.emouseatlas.org). The current eLearning content are the tutorials produced by Professor José García Monterde of the University of Córdoba, and the presentation from collaboration between Professor Monterde and the[…]

New data reveals gene expression during mouse embryo development

Posted by on September 29th, 2016

This article was originally posted on the DMDD website dmdd.org.uk Knowing the ‘normal’ expression of genes during embryo development is key to understanding the differences that occur due to genetic mutations. As part of work to understand the underlying transcriptional processes for developing embryos from knockout mouse lines, DMDD has now released a gene expression[…]

Exciting news on neural stem cell niches: stunning research from Fiona Doetsch’s lab

Posted by on August 26th, 2016

http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(16)30163-1 Sense & Sensibility: niche signals regulate neural stem cells in an age-dependent manner paper feature by Thomas Schwarz-Romond Tissue specific stem cell niches provide lifelong support for adult stem cells. The cell-biological dissection of (adult neural) stem cell – niche interactions uncovered unexpected regulatory functions. These new results imply that stem cell niches actively[…]

FaceBase: An online resource for craniofacial research

Posted by on August 16th, 2016

In 2009, FaceBase was launched in response to the need for more comprehensive analysis of craniofacial development: with so much craniofacial data being generated, there is a danger of relevant datasets being buried in the avalanche of genomic and other data. FaceBase is a curated, one-stop shop for facial development and research offering the community input and[…]