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Uncovering Non-canonical Roles of E-cadherin Beyond Cell Adhesion

Posted by on February 14th, 2017

Broad perspective Successful division was an essential criterion for establishing the cell as the basic unit of life on earth. Later, cell-cell adhesion made possible the evolution of multicellular life forms. These two fundamental cellular processes co-function throughout the life of an organism, during development, wound healing and tissue regeneration. In epithelial tissues this results[…]

Developing the auxin-inducible degradation (AID) system for versatile conditional protein depletion in C. elegans

Posted by on March 19th, 2016

By Liangyu Zhang and Abby F. Dernburg    The nematode Caenorhabidis elegans is among the most widely used and powerful model organisms for studying mechanisms underlying cellular and developmental processes. Although a variety of approaches for conditional protein expression have been developed in C. elegans, available tools for conditional protein depletion are far more limited,[…]

An interview with Philip Zegerman

Posted by on September 15th, 2015

This interview first featured in the Journal of Cell Science and is part of their interview series Cell Scientists to Watch   Philip Zegerman earned his undergraduate degree from the University of Cambridge, where he later also pursued a PhD in the lab of Tony Kouzarides at the Gurdon Institute. For his postdoctoral work, he switched[…]

BSDB Gurdon Summer Studentship Report (3)

Posted by on February 3rd, 2015

In 2014, the British Society of Developmental Biology (BSDB) has initiated the Gurdon Summer Studentship program with the intention to provide highly motivated students with exceptional qualities and a strong interest in Developmental Biology an opportunity to engage in practical research. The 10 successful applicants spent 8 weeks in the research laboratories of their choices,[…]

A day in the life of a C. elegans lab

Posted by on March 3rd, 2014

I am Serena Ding, a third year PhD student, and I work at the University of Oxford’s Biochemistry Department in the United Kingdom. I am interested in the control of cell divisions, specifically in stem cells. In Dr Alison Woollard’s lab, we use a microscopic nematode called Caenorhabditis elegans as a stem cell model.  […]

RI Christmas Lectures 2013- Developmental Biology in the spotlight

Posted by on December 20th, 2013

The Royal Institution Christmas Lectures are an annual event where science is celebrated and young people are inspired. This year’s lectures celebrate the Life Fantastic, and will showcase the excitement, beauty and medical potential of developmental biology.   If you were brought up in the UK, the Royal Institution (RI) Christmas Lectures will have been[…]

Worm Watch Lab: Real data, real outreach

Posted by on November 27th, 2013

Research, write grants, publish papers, teach, manage staff, collaborate. And now engage the public?! Most scientists have their hands full, and while public engagement sounds nice in the abstract, actually finding time to do it well can be a challenge. This is the beauty of citizen science: it’s not just outreach, it let’s you get[…]

Woods Hole images round 4- choose a movie to be a Development cover!

Posted by on September 5th, 2013

For the last round of Woods Hole images this year we have an exciting development- the last round is a movie round! Below are 4 great movies from last year’s Woods Hole embryology course, and you can vote for your favourite. The most voted movie will be featured in the homepage of Development and a still[…]

The embryonic cell lineage of C. elegans, revisited and revisualized

Posted by on October 26th, 2012

On my desk sits a tattered photocopy of one of the pinnacles of modern developmental biology, the “embryonic lineage” paper by John Sulston, et al. (1983). In this paper, Sulston et al. completed a project begun in the late 19th century, namely to trace the complete genealogy of all cells in a nematode embryo. C.[…]

Worms teach about germline stem cells

Posted by on October 10th, 2012

To me, the stem cells within a germline are a perfect storm of fascination.  Stem cells are, of course, intriguing in their ability to self-renew and differentiate, and a germline is intriguing in its ability to generate gametes.  Add stem cells and germlines together, and you have amazing biology in front of you…and more biology[…]