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The right information

Posted by on October 19th, 2017

Oscar H. Ocaña and M. Angela Nieto Comment on “A right-handed signalling pathway drives heart looping in vertebrates”. Nature 549, 86-90 (2017).   A fundamental aspect of vertebrates is their external bilateral symmetry, which has to some extent shaped evolutionary success. Not only is beauty associated with symmetry, enhancing an individual’s chance of mating but[…]

A Crumby affair: Cell ingression during gastrulation

Posted by on January 31st, 2017

Comment on “Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation” Ramkumar N, Omelchenko T, Silva-Gagliardi NF, McGlade CJ, Wijnholds J, Anderson KV. Nat Cell Biol. 2016 Dec;18(12):1281-1291   “It is not birth, marriage, or death, but gastrulation, which is truly the most important time in your life.” Lewis Wolpert (1986)   Aptly stated by Wolpert, gastrulation is the fundamental process[…]

How mechanical signals orchestrate stem cell fate

Posted by on August 23rd, 2016

Controlling differentiation using biophysical cues from development Embryonic stem cells have the potential to become any cell type in the adult organism, but coaxing them to a specific fate continues to be a challenge for researchers. While many of the soluble signals involved in patterning the early embryo are well-established, only recently have tools been[…]

From our sister journals- February 2016

Posted by on February 22nd, 2016

Here is some developmental biology related content from other journals published by The Company of Biologists.           Using the developmental biology toolkit to study cancer Aiello and Stanger review the similarities between embryogenesis and cancer progression and discuss how the concepts and techniques of developmental biology are being applied to provide insight into[…]

The 7th International EMT Meeting (Oct. 11-14, 2015; Melbourne, Australia)

Posted by on April 21st, 2015

The 7th International EMT Meeting will be held in Melbourne, Australia in October 2015. The meeting has been a key venue for bringing together developmental, cell and cancer biologists and has recently increased the presence of stem cell and modeling-related topics. Meeting name: TEMTIA-VII: The EMT (Epithelial Mesenchymal Transition) International Association Meeting VII Web Link:[…]

Gastrulation: Local actions, global movements and self-organisation

Posted by on June 6th, 2014

Cells move in (still) mysterious ways to achieve morphogenesis. Prominently, cells of an early vertebrate embryo (blastula, a mass of undifferentiated cells) move extensively during gastrulation to generate the three basic layers of the organism: ectoderm at the surface, endoderm presaging the digestive tube, and the mesoderm in between. At the end of the process,[…]