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Displaying posts with the tag: human-development [Clear Filter]

From stem cells to human development: registration now open!

Posted by on December 12th, 2017

  Development is delighted to announce the third in our highly successful series of events focussing on human developmental biology. Since the initiation of this series, in 2014, we have witnessed huge progress in this field, with more and more researchers turning to stem cell and organoid systems to investigate development and organogenesis in vitro, as[…]

Exploring the differences between mice and men during cerebral cortex development

Posted by on December 5th, 2017

Alzu’bi A, Lindsay SJ, Harkin LF, McIntyre J, Lisgo SN, Clowry GJ (2017) The transcription factors COUP-TFI and COUP-TFII have distinct roles in arealisation and GABAergic interneuron specification in the early human fetal telencephalon. Cerebral Cortex 27: 4677-4690.   One author’s perspective on the origins of this study (Gavin Clowry)   For me the origins[…]

Special issue of Development on human development

Posted by on November 13th, 2017

Development is pleased to welcome submissions for an upcoming special issue on human development. This issue will focus on advances in our understanding of how human organs and tissues are formed, and how the processes and mechanisms involved compare to those in other species. This special issue will be published in early autumn 2018, to coincide[…]

The evolution from mouse to human models of lung development

Posted by on September 4th, 2017

The story behind our eLife paper: Nikolić, M. Z., Caritg, O., Jeng, Q., Johnson, J.-A., Sun, D., Howell, K. J., Brady, J. L., Laresgoiti, U., Allen, G., Butler, R., Zilbauer, M., Giangreco, A., Rawlins E.L. (2017). Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids. Elife[…]

Reactions to the CRISPR human embryo paper

Posted by on August 3rd, 2017

A paper published online yesterday in Nature (and ‘leaked’ a week ago by the MIT Technology Review) describes the use of CRISPR in human embryos to correct a mutation that causes hypertrophic cardiomyopathy. The work has hit the headlines and sparked debate about its utility and implications. Collated below are responses from the field (or[…]

From Stem Cells to Human Development, Southbridge, 2016. Mini report.

Posted by on October 12th, 2016

Two years ago, Development held a meeting on the emerging field of stem cells and human development. In announcing the meeting, the organisers described a knowledge gap:   “Strikingly, although we understand intimate details of the development of a broad range of vertebrate and invertebrate species, we know almost nothing about the development of the[…]

Staff Scientist/Research Assistant II – Pluripotent Stem Cells and Cartilage Biology

Posted by on October 10th, 2016

We are looking for an enthusiastic and highly motivated Staff Scientist or experienced Research Assistant/Technician to join the stem cell and regenerative medicine-based laboratory of Dr. April Craft, within the department of Orthopaedic Research at Boston Children’s Hospital and Harvard Medical School. Our lab studies the development of musculoskeletal tissues, primarily articular cartilage, using human[…]

From naïve pluripotency to chimeras: a new ethical challenge?

Posted by on December 18th, 2014

This article by Insoo Hyun was first published in  Development. Also read the companion ethics article here.   In recent years, there has been much interest in the prospect of generating and using human stem cells that exhibit a state of naïve pluripotency. Such a pluripotent state might be functionally confirmed by assessing the chimeric contribution of these cells to non-human blastocysts. Furthermore, the[…]

Looking inwards: opening a window onto human development

Posted by on December 16th, 2014

This editorial was first published in Development. It was written by Olivier Pourquié, Benoit Bruneau, Gordon Keller and Austin Smith.   The past 30 years or so have witnessed tremendous advances in the field of developmental biology. This has resulted in a growing (although still incomplete) understanding of the molecular basis of embryonic development, including characterization of signals and genes involved[…]

From Stem Cells to Human Development: the video

Posted by on November 13th, 2014

We have previously posted about the workshop that Development organised in September, titled ‘From Stem Cells to Human Development’. We provided a general summary of the meeting, as well as an overview of the stem cells ethics discussion that took place at the workshop. In addition, we have just published a video on this workshop on our YouTube[…]