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Displaying posts with the tag: polycomb [Clear Filter]

The people behind the papers – Jinjin Zhu & Justin Kumar

Posted by on April 9th, 2018

Cell fate commitment relies on both activation of appropriate genes and suppression of inappropriate ones. Polycomb group proteins are known to be crucial epigenetic silencers of developmental genes, but the manner by which they control fateĀ in vivo, and the relative roles of different Polycomb proteins in silencing, have remained unclear. A new paper in Development[…]

In Development this week (Vol. 138, Issue 12)

Posted by on May 24th, 2011

Here are the highlights from the current issue of Development: How transcriptional silencing goes into reverse The Polycomb group (PcG) machinery silences terminal differentiation genes in stem cell lineages. Reversal of this epigenetic transcriptional silencing is implicated in the selective activation of these genes during differentiation, but little is known about the mechanism of this[…]

In Development this week (Vol. 138, Issue 1)

Posted by on December 7th, 2010

The first issue of 2011 is out now…here are the highlights: Geminin control of lineage commitment The transition between pluripotency and multi-lineage commitment during early embryogenesis must be closely regulated to ensure correct spatial and temporal patterning of the embryo. But what regulates this crucial transition? According to Kristen Kroll and co-workers, part of the[…]

In Development this week (Volume 137, Issue 15)

Posted by on July 13th, 2010

Here are the research highlights from the new issue of Development… TORc1-ing about stem cell differentiation In adult tissues, the tight regulation of stem cell selfrenewal and differentiation maintains tissue homeostasis. In Drosophila ovaries, BMP signalling from the local environment maintains germline stem cells (GSCs) by repressing bam (a differentiation-promoting gene) expression. Now, on p.[…]