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The people behind the papers: Alaa Hachem and John Parrington

Posted by on August 16th, 2017

Embryogenesis begins with fertilisation, and defective activation of the egg by the sperm is implicated in human infertility. Today’s paper, published in the most recent issue of Development, investigates the role of the sperm protein PLCζ in egg activation and the calcium oscillations that accompany it. We caught up with co-first author Alaa Hachem and his[…]

The people behind the papers – Giri Dahal, Sarala Pradhan & Emily Bates

Posted by on August 2nd, 2017

Ion channels are famous for their roles in neurons and muscles, but the spectrum of phenotypes seen in ion channel mutants indicate a diversity of roles in development; the underlying mechanisms, however, have remained opaque. This week we feature a paper published in the latest issue of Development that reveals a link between potassium channels and morphogen[…]

The people behind the papers – Ivette Olivares-Castiñeira & Marta Llimargas

Posted by on July 21st, 2017

The Drosophila tracheal system is a powerful model for understanding the genetic and cell biological control of tubulogenesis. In their new PLoS Genetics paper, Ivette Olivares-Castiñeira and her PI Marta Llimargas of the Molecular Biology Institute of Barcelona connect EGFR signalling to intracellular cell trafficking during tracheal morphogenesis. We caught up with Marta and Ivette to hear the story behind[…]

The people behind the papers – Kimberly McArthur & Joseph Fetcho

Posted by on July 20th, 2017

Development depends on cells coming together in the right place to form functioning tissues. Our latest paper in this series was published recently in Current Biology and asks what happens to the structure and function of the nervous system when motor neuron migration – and hence final position – is disrupted. We caught up with postdoc[…]

The people behind the papers: Lijun Chi and Paul Delgado-Olguin

Posted by on June 9th, 2017

Development of the placental vasculature – known as the labyrinth – is critical for foetal development. Today’s paper comes from the most recent issue of Development and addresses the signalling events involved in placental vascular maturation. We caught up with lead author Lijun Chi and her PI Paul Delgado-Olguin of the Hospital for Sick Children and University[…]

The people behind the papers: Gabriel Krens and Carl-Philipp Heisenberg

Posted by on May 25th, 2017

Cell sorting is a critical process during development, as differently specified cells are segregated to the right parts of the embryo. Differences in cell adhesion and cortical tension are thought to be crucial to this process, but the mechanics have been difficult to probe in vivo. This week’s paper, published in the current issue of[…]

The people behind the papers: Jun-Ho Ha, Hyo-Jun Lee and Chung-Mo Park

Posted by on May 11th, 2017

Our 20th instalment of this series comes from South Korea and features an investigation into the molecular basis of how temperature influences developmental transitions in Arabidopsis seedlings, recently published in Developmental Cell. We caught up with joint first authors Jun-Ho Ha and Hyo-Jun Lee, and their supervisor Chung-Mo Park, Professor in the Department of Chemistry, Seoul National University (SNU), to hear[…]

The people behind the papers: Adam Davis, Nirav Amin and Nanette Nascone-Yoder

Posted by on April 13th, 2017

In spite of our external appearance, our innards are asymmetric. For today’s interview, we feature a paper published recently in Development that provides a cellular and molecular investigation into symmetry breaking in a poorly understood organ, the stomach. We caught up with first authors Adam Davis and Nirav Amin, and their supervisor Nanette Nascone-Yoder, Associate Professor in North Carolina State University, Raleigh,[…]

The people behind the papers: Dae Seok Eom & David Parichy

Posted by on April 7th, 2017

Macrophages are usually associated with immunity, but have increasingly appreciated functions in development and homeostasis. This week we meet the authors of a recent Science paper that identified a role for macrophages in zebrafish stripe patterning, revealing a remarkable ‘relay’ mechanism whereby macrophages help one type of cell signal to another via cytoplasmic extensions. Postdoc[…]

The people behind the papers: Thanh Vuong-Brender & Michel Labouesse

Posted by on March 30th, 2017

This year marks the centenary of D’Arcy Thompson’s On Growth and Form, an attempt to outline the physical and mathematical principles underpinning the generation of biological form. Modern day developmental biologists, bolstered by new technologies, have taken up Thompson’s cause to try to understand the mechanics of development, particularly with regard to morphogenesis. While the generation[…]