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Displaying posts with the tag: the-people-behind-the-papers [Clear Filter]

The people behind the papers – Guillaume Blin, Manuel Thery & Sally Lowell

Posted by on September 21st, 2018

During early mouse development, a series of signalling interactions breaks the symmetry of the egg cylinder, spatially organising the embryo into territories that define the future axes of the body. Symmetry breaking can also be observed in embryonic stem cell (ESC) colonies cultured on micropatterned substrates, which thus provide a powerful system to test the[…]

The people behind the papers – Jaqueline Kinold & Hermann Aberle

Posted by on September 4th, 2018

Axon guidance relies on the reception and integration of molecular cues from the environment by growth cones, and defective pathfinding results in misplaced projection patterns in the mature nervous system. A new paper in Development investigates this process in the Drosophila neuromucular system, as well as the consequences of axonal miswiring to locomotion. We caught up[…]

The people behind the papers – Anjali Rao & Carole LaBonne

Posted by on August 9th, 2018

The neural crest is a progenitor population with the capacity to contribute to all vertebrate germ layers. The transcription factor and signalling pathway activity underlying this remarkable pluripotency have been well studied, but the role of the epigenetic state is less well understood. A new paper in Development examines the role of histone acetylation in regulating[…]

The people behind the papers – Takanori Wakatake & Ken Shirasu

Posted by on July 23rd, 2018

Parasitic plants are fascinating and agriculturally relevant organisms that rely for their success on the haustorium, a specialised root structure that invades host root vasculature to derive nutrients and water. A recent paper in Development addresses the developmental origins of these crucial structures in the facultative root parasite Phtheirospermum japonicum. We caught up with first author Takanori Wakatake and[…]

The people behind the papers – Ximena Anleu Gil & Dominique Bergmann

Posted by on July 18th, 2018

Asymmetric division is a widespread mechanism for generating cellular diversity during developmental patterning. The stomata of flowering plants are epidermal valves that regulate gas exchange, and provide an accessible system to investigate the mechanisms of asymmetric cell division both within and across species. A paper in the new issue of Development reports an investigation of the molecular control of this[…]

The people behind the papers – Martina Nagel & Rudolf Winklbauer

Posted by on July 6th, 2018

Contact inhibition of locomotion is a widespread phenomenon in migrating cells. However, cells often migrate collectively as a sheet, raising the question of how contact inhibition is overcome in these scenarios. A new paper in Development addresses this problem by studying the signals that regulate collective migration in Xenopus leading edge mesendoderm (LEM) cells. We[…]

The people behind the papers – Kana Ishimatsu, Tom Hiscock & Sean Megason

Posted by on June 12th, 2018

Somites are segmented structures  which give rise to numerous tissues in the vertebrate body. It has long been observed that somites scale in size with the overall size of the embryo, both as development proceeds and between individuals of different sizes, but the molecular underpinnings of this process have remained controversial. A new paper in[…]

The people behind the papers – Pauline Anne & Christian Hardtke

Posted by on May 25th, 2018

Short CLE peptides regulate a wide variety of processes during plant development. In the developing root, the receptors and co-receptors for CLEs have remained largely unclear, as have the relationships between different CLEs and different (co-)receptors. A new paper in Development addresses this problem by reporting a new receptor kinase involved in CLE signaling. We caught[…]

The people behind the papers – Cathy Pichol-Thievend, Natasha Harvey & Mathias Francois

Posted by on May 22nd, 2018

The vertebrate lymphatic vascular network provides crucial circulatory and immune functions but its developmental origin has been a contentious issue, in particular the question of whether lymphatic endothelial cells have an exclusively venous origin. A new paper in Development addresses this issue in the dermis of the mouse embryo. To find out more about the[…]

The people behind the papers – Samira Benhamouche-Trouillet, Evan O’Loughlin & Andrea McClatchey

Posted by on May 21st, 2018

Intrahepatic bile ducts (IHBDs) are epithelial tubular structures that transport bile from the liver to the intestine, but the molecules and mechanisms controlling IHBD morphogenesis have remained largely unclear. A a recent paper in Development reports an investigation into IHBD development and the role the tumour suppressor and cytoskeletal regulator Merlin plays in the process. We caught[…]