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Displaying posts with the tag: the-people-behind-the-papers [Clear Filter]

The people behind the papers – Pauline Anne & Christian Hardtke

Posted by on May 25th, 2018

Short CLE peptides regulate a wide variety of processes during plant development. In the developing root, the receptors and co-receptors for CLEs have remained largely unclear, as have the relationships between different CLEs and different (co-)receptors. A new paper in Development addresses this problem by reporting a new receptor kinase involved in CLE signaling. We caught[…]

The people behind the papers – Cathy Pichol-Thievend, Natasha Harvey & Mathias Francois

Posted by on May 22nd, 2018

The vertebrate lymphatic vascular network provides crucial circulatory and immune functions but its developmental origin has been a contentious issue, in particular the question of whether lymphatic endothelial cells have an exclusively venous origin. A new paper in Development addresses this issue in the dermis of the mouse embryo. To find out more about the[…]

The people behind the papers – Samira Benhamouche-Trouillet, Evan O’Loughlin & Andrea McClatchey

Posted by on May 21st, 2018

Intrahepatic bile ducts (IHBDs) are epithelial tubular structures that transport bile from the liver to the intestine, but the molecules and mechanisms controlling IHBD morphogenesis have remained largely unclear. A a recent paper in Development reports an investigation into IHBD development and the role the tumour suppressor and cytoskeletal regulator Merlin plays in the process. We caught[…]

The people behind the papers – Sa Geng & James Umen

Posted by on April 19th, 2018

The transition to multicellularity in eukaryotes appears to be intimately linked to the transition from isogamy (gametes of the same size) to anisogamy (gametes of distinct sizes), and indeed to oogamy, a form of anisogamy with a large, immotile egg and a motile sperm. Volvocine algae provide a useful and fascinating model to study how[…]

The people behind the papers – Jinjin Zhu & Justin Kumar

Posted by on April 9th, 2018

Cell fate commitment relies on both activation of appropriate genes and suppression of inappropriate ones. Polycomb group proteins are known to be crucial epigenetic silencers of developmental genes, but the manner by which they control fate in vivo, and the relative roles of different Polycomb proteins in silencing, have remained unclear. A new paper in Development[…]

The people behind the papers – Rémi-Xavier Coux & Ruth Lehmann

Posted by on April 5th, 2018

Development and homeostasis depend crucially on the maintenance of cell identity, and in gamete-producing tissues the somatic/germline distinction is paramount. A recent paper in Development explores how cell identity is secured in the Drosophila ovary by studying the function of the conserved tumour suppressor L(3)mbt. To find out more about the story, we caught up with first author Rémi-Xavier[…]

The people behind the papers – You Wu & Mineko Kengaku

Posted by on March 12th, 2018

Neuronal migration is critical for mammalian brain development. In many migrating neurons, the nucleus translocates from the trailing to the leading edge of the cell in a manner dependent on the actin and microtubule cytoskeletons, but how these cytoskeletons interact and their relative contribution to the forces that move the nucleus has remained unclear. This[…]

The people behind the papers – Marina Matsumiya & Ryoichiro Kageyama

Posted by on February 19th, 2018

Vertebrate segmentation involves the periodic formation of somites from the presomitic mesoderm, in a manner controlled by oscillating gene expression (the oscillations of the segmentation clock must be one of the marvels of nature!). While in vivo work has provided a framework for studying the process, many aspects of segmentation dynamics are obscured in the embryo. A new Techniques[…]

The people behind the papers – Chloé Dominici & Alain Chédotal

Posted by on January 18th, 2018

Vertebrate brain development is characterised by cell migration, as neurons are often born far from where they need to end up. Migration is regulated by guidance cues and their receptors, but, problematically, many of these molecules are expressed throughout the brain, complicating efforts to spatially and temporally pin down their function. A paper in the[…]

The people behind the papers – Alok Javali, Aritra Misra & Ramkumar Sambasivan

Posted by on December 20th, 2017

Neuromesoderm progenitors are a population of stem cells that contribute to the neural tube and somite-forming paraxial mesoderm, and promote axial growth of the vertebrate embryo. In the latest issue of Development, a new paper addresses the transcriptional control of fate determination in this fascinating cell lineage. We caught up with co-first authors Alok Javali and[…]