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The people behind the papers: Adam Davis, Nirav Amin and Nanette Nascone-Yoder

Posted by on April 13th, 2017

In spite of our external appearance, our innards are asymmetric. For today’s interview, we feature a paper published recently in Development that provides a cellular and molecular investigation into symmetry breaking in a poorly understood organ, the stomach. We caught up with first authors Adam Davis and Nirav Amin, and their supervisor Nanette Nascone-Yoder, Associate Professor in North Carolina State University, Raleigh,[…]

The people behind the papers: Dae Seok Eom & David Parichy

Posted by on April 7th, 2017

Macrophages are usually associated with immunity, but have increasingly appreciated functions in development and homeostasis. This week we meet the authors of a recent Science paper that identified a role for macrophages in zebrafish stripe patterning, revealing a remarkable ‘relay’ mechanism whereby macrophages help one type of cell signal to another via cytoplasmic extensions. Postdoc[…]

The people behind the papers: Thanh Vuong-Brender & Michel Labouesse

Posted by on March 30th, 2017

This year marks the centenary of D’Arcy Thompson’s On Growth and Form, an attempt to outline the physical and mathematical principles underpinning the generation of biological form. Modern day developmental biologists, bolstered by new technologies, have taken up Thompson’s cause to try to understand the mechanics of development, particularly with regard to morphogenesis. While the generation[…]

The people behind the papers: Holly Voges, Enzo Porrello & James Hudson

Posted by on March 15th, 2017

The use of organoids – which can be defined as artificially grown masses of cells or tissue that resemble organs – in basic and clinical research has snowballed in recent years, providing insight into fundamental developmental processes and disease etiology. Today’s paper comes from the new Special Issue of Development devoted entirely to organoids, and reports the use of human[…]

The people behind the papers: Matthias Tisler & Martin Blum

Posted by on February 21st, 2017

Conjoined twins have fascinated biologists for centuries. In twins joined at the thorax, left-right patterning is disrupted, but only in one half of the right hand twins. Today’s paper, from this week’s issue of Current Biology, tackles this enigmatic phenomenon using Xenopus, and reveals that laterality in conjoined twins is determined by cilia-driven leftward flow.[…]

The people behind the papers: Rute Tomaz & Véronique Azuara

Posted by on February 15th, 2017

Embryonic stem cells express genes necessary for self-renewal, and also ‘prime’ lineage-specific genes which stay silent until differentiation; the molecular players and pathways that govern the timely gene expression are still being delineated. Today’s paper comes from the most recent issue of Development and reveals a role for the histone demethylase Jmjd2c in gene activation in stem cell[…]

The people behind the papers: Philippe Foerster & Nathalie Spassky

Posted by on February 8th, 2017

Radial glial cells are multipotent progenitors in the developing vertebrate brain. At their apical interface with the ventricular cavity around which the brain forms, they bear a primary cilium, a signalling and sensory organelle crucial for proper brain development. Today’s paper, from a recent issue of Development, addresses the link between these primary cilia and brain morphogenesis.[…]

The people behind the papers: Nicolas Macaisne & J. Mark Cock

Posted by on February 1st, 2017

The brown alga Ectocarpus has emerged as a model system for the evolution of muticellularity. Today’s paper, from the current issue of Development, investigates the role and evolutionary history of a gene implicated in Ectocarpus development. We caught up with first author Nicolas Macaisne and supervisor J. Mark Cock of the Station Biologique de Roscoff in Brittany.     Mark, can you[…]

The people behind the papers: Ehsan Pourkarimi & Iestyn Whitehouse

Posted by on January 25th, 2017

How does a developing embryo coordinate DNA replication with gene transcription? This fundamental question is the focus of today’s paper, recently published in eLife. We caught up with lead author Ehsan Pourkarimi and his supervisor Iestyn Whitehouse, Assistant Professor in the Sloan Kettering Institute’s Molecular Biology programme, to hear the story behind the work.     Iestyn, can you[…]

The people behind the papers: Miguel Brun-Usan & Isaac Salazar-Ciudad

Posted by on January 4th, 2017

The tenth paper featured in this series comes from the first issue of Development for 2017, and uses computational modelling to investigate the importance of different cellular processes in spiral cleavage of the early embryo. We caught up with the paper’s first author Miguel Brun-Usan and Isaac Salazar-Ciudad, group leader at the University of Helsinki[…]