the community site for and by developmental biologists

Tissue-specific genome editing in Ciona embryos by CRISPR/Cas9

Posted by on October 31st, 2014

Researchers have always been interested in tissue-specific loss of function to probe the role of specific genes in embryonic development, cell physiology and disease conditions. Migration of lateral plate primordial germ cells in zebrafish, border cell migration during oogenesis in drosophila, interaction of T-cells with their target, and numerous other cases have continued to give[…]

A day in the life of a shark lab

Posted by on October 31st, 2014

Hi! I am Nuria, a PhD student. I work in the Department of Cell Biology at the University of Santiago de Compostela (Spain). Our group, the BRAINSHARK group, has been working in the evolutionary changes occurring during the development of the nervous system of a small shark (Scyliorhinus canicula) for many years. Our work mostly[…]

A mechanism that allows a differentiated cell to reactivate as a stem cell revealed

Posted by on October 29th, 2014

The study, performed with fruit flies, describes a gene that determines whether a specialized cell conserves the capacity to become a stem cell again. Unveiling the genetic traits that favour the retention of stem cell properties is crucial for regenerative medicine. Published in Cell Reports, the article is the fruit of collaboration between researchers at[…]

Barcelona BioMed Conference: Drosophila as a model in cancer (15 Jun 2015 to 17 Jun 2015)

Posted by on October 29th, 2014

Barcelona BioMed Conference: Drosophila as a model in cancer 15 – 17 Jun 2015 Cancer is a multi-hit process involving mutations in oncogenes and tumour suppressors, as well as interactions between the tumour cells and the surrounding normal tissue. The fruit fly, Drosophila, is an excellent, genetically-tractable system for modelling the development of cancer, due to the[…]

4 Yr PhD Programme in Developmental Mechanisms

Posted by on October 27th, 2014

Applications are open for the Wellcome Trust funded four year PhD programme in Developmental Mechanisms at Cambridge. We are looking for talented, motivated graduates or final year undergraduates, and are keen to attract outstanding applicants in the biological sciences, who are committed to doing a PhD. We are able to fund both EU and non-EU[…]

Biology and maths partner to understand life decisions

Posted by on October 26th, 2014

Starting with the one fertilized egg that we all once were, embryonic development is made of cell divisions and most importantly of cell decisions. These first life decisions are the first steps of the development of various cell types, which will further divide, decide, specialize, organize, form specialized organs and ultimately an entire very complex[…]

Public Engagement Officer

Posted by on October 24th, 2014

Department/Location: Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute Salary: £28,695-£37,394 Reference: PS03788 Closing date: 16 November 2014 Fixed-term: The funds for this post are available until 30 June 2017 in the first instance. The Stem Cell Institute is a world-leading centre of excellence in stem cell biology and regenerative medicine, supported by[…]

Post-doc and research assistant positions in Drosophila planar polarity

Posted by on October 22nd, 2014

Two Wellcome Trust-funded positions are available for candidates with a background in cell and/or developmental biology to join an interdisciplinary team investigating cell signalling and coordinated cell polarisation using Drosophila epithelial development as a model system. The Strutt lab ( studies cell signalling and coordinated cell polarisation in animal tissues via analysis of the “core”[…]

Human Stem Cell research: new ethical questions?

Posted by on October 21st, 2014

The Ethics Session at the Company of Biologists “From Stem Cells to Human Development” workshop Last September the Company Of Biologists organized an exciting three-day dive into the biology of human stem cells and their use to study human development and regeneration (look out for the full meeting report in Development, coming soon, and Katherine[…]

In Development this week (Vol. 141, Issue 21)

Posted by on October 21st, 2014

Here are the highlights from the new issue of Development:   Two top tips for angiogenesis The widely accepted model of angiogenic sprouting proposes that a single cell – the tip cell – is found at the leading edge of vessel sprouts. Now, Victoria Bautch and colleagues describe an alternative blood vessel topology in which[…]