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An illustrated anatomical ontology of the developing mouse lower urogenital tract

Posted by , on 25 May 2015

Georgas et al. have presented a comprehensive update to the anatomical ontology of the murine urogenital system. These updates pertain to the lower urinary tract, genital tubercle and associated reproductive structures, covering stage E10.5 through to adult. The updates have been based on recently published insights into the cellular and gross anatomy of these structures, tissue layers and cell types. Included are representative schematic illustrations, detailed text descriptions and molecular markers that selectively label muscles, nerve/ganglia and epithelia of the lower urogenital system. The revised ontology will be an important tool for researchers studying urogenital development/malformation in mouse models and will improve our capacity to appropriately interpret these with respect to the human situation.

Nerves, pelvic ganglia and vasculature of the LUT.
Example of new schematics that support the revised ontology. (A-F) E15 schematics illustrate nerves, pelvic ganglia (green) and vasculature. Pelvic ganglia extend their processes towards the PLUR midline (D) and bladder fundus (E,F). Only small areas of pelvic ganglia are visible in midline sagittal sections (A). (B,C) Bladder (E14 to adult) and PLUR (E17 to adult) ontology terms. Nerves are present in each tissue layer, in addition to nerves of blood vessels (arrowhead, B).

The updated ontology and definitions (including features, synonyms, molecular markers and lineage relationships where established) are available on the GUDMAP website (http://www.gudmap.org/Resources/Ontology/index.php). The ontology has been entered into the EMAP mouse embryo ontology (Hayamizu et al., 2013) and published on the Open Biological and Biomedical Ontologies web resource (http://www.obofoundry.org/).

 

 

 

 

 

 

 

 

 




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