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The story of my heart, from the bottom of my heart (says the Zebrafish)

Posted by on June 23rd, 2020

I started off as quite little—just one cell, in fact. No heart, no brain, no blood flowed in me and yet, somehow I found the motivation in me to divide. One me made two and two mes made four, till many tiny mes made me a full-fledged embryo with a heart full of hope. As[…]

Early development: the journey from oocyte to embryo

Posted by on April 3rd, 2020

Meeting report: 2nd EMBO workshop “Awakening of the genome: the maternal-to-zygotic transition”   Amanda Amodeo1*, Johanna Gassler2* and Ksenia Kuznetsova3*, Philip Zegerman4   *These authors contributed equally Lewis-Sigler Institute for Integrative Genomics. Carl Icahn Laboratory Washington Rd., Princeton University. Princeton, NJ 08544 Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter[…]

Job opening: 3D + time live imaging data analyst and software developer

Posted by on September 21st, 2019

The Tunicate embryology Research Team and the MRI core imaging facility in Montpellier, France, have an opening for a computer scientist in charge of the analysis of 3D + time fluorescence imaging data of living embryos of a class of marine invertebrates, the ascidians. The contract is for up to 4 years. The selected candidate[…]

Inflate your embryo

Posted by on September 17th, 2019

How would you create a hole between two sticky surfaces? Simply crack it! At a first glance, trying to pull apart the two surfaces seems to be a good idea, but in practice, you might need a lot of energy. However, it seems that the mouse embryo has found a smart and efficient way to do[…]

POSTDOC IN DEVELOPMENTAL METABOLISM (Francis Crick Institute, London)

Posted by on July 12th, 2019

Roles of metabolism in the developmental origins of health and longevity A postdoctoral research position funded by the Wellcome Trust is available in the laboratory of Dr. Alex Gould at the Francis Crick Institute in London. The lab works on the mechanisms by which dietary nutrients during development can have profound long-term effects upon adult[…]

Postdoctoral opportunity in image analysis and biophysical modeling of developing systems

Posted by on January 8th, 2019

Postdoctoral position in the Saunders laboratory, Mechanobiology Institute, Singapore A postdoctoral research position in quantitative biology is available from March 2019 in Asst. Prof. Timothy Saunders’ group at the Mechanobiology Institute, Singapore. The Saunders lab has been active since 2013 and studies the fundamental processes shaping organs and tissues during development. The Saunders lab extensively[…]

Postdoctoral Position on mammalian gastrulation

Posted by on October 3rd, 2018

Research Associate/Fellow position (3 years) to work on a BBSRC funded project investigating cell fate regulation during mammalian gastrulation in the laboratory of Dr. Ramiro Alberio (U. of Nottingham, UK), in collaboration with Prof. Jennifer Nichols (U. of Cambridge, UK) and Dr Matt Loose (U. of Nottingham). Project description: The project will investigate the molecular[…]

Fat to the forefront of histone regulation

Posted by on August 21st, 2018

All life requires energy. For early metazoan development, demand is especially high, as the transition from a single cell to a complex, multicellular organism requires a massive energetic input. In the earliest stages of development, however, an organisms’ inability to feed poses an apparent problem: how is the energy necessary to drive development obtained? In[…]

Blastoid: the backstory of the formation of blastocyst-like structure solely from stem cells.

Posted by on June 27th, 2018

In our recently published paper1, we showed that mouse stem cells self-organize into blastocyst-like structures, that we termed blastoids. Because blastoids can be generated in large numbers, can be finely manipulated, and implant in utero, they are a powerful tool to investigate the principles of pre- and post-implantation development. Here is the backstory of our[…]

PhD in nerve/tumor interactions and nervous system development

Posted by on June 18th, 2018

Applications are invited from highly motivated individuals dedicated to peruse a PhD and who are interested in nerve/tumour interactions and nervous system development.    PROJECT DESCRIPTION During tumour progression nerves and tumours interact resulting in tumour cells using nerves as a metastatic route out of the organ, through a process called perineural invasion (PNI). While this[…]