Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints.

The preprints this month are hosted on bioRxiv and arXiv – use these links below to get to the section you want:

Developmental biology

• Patterning & signalling
• Morphogenesis & mechanics
• Genes & genomes
• Stem cells, regeneration & disease modelling
• Plant development
• Evo-devo

Cell Biology

Modelling

Tools & Resources

Developmental biology

| Patterning & signalling

Multiple Notch ligands in the synchronization of the segmentation clock

Marcos Wappner, Koichiro Uriu, Andrew C. Oates, Luis G. Morelli

Spatiotemporal Characterization of Cyclooxygenase Pathway Enzymes During Vertebrate Embryonic Development

Tess A. Leathers, Raneesh Ramarapu, Crystal D. Rogers

The multi-level effect of chlorpyrifos during clownfish metamorphosis

Mathieu Reynaud, Stefano Vianello, Shu-Hua Lee, Pauline Salis, Mélanie Dusseune, Kai Wu, Bruno Frederich, David Lecchini, Laurence Besseau, Natacha Roux, Vincent Laudet

Retinoic acid breakdown is required for proximodistal positional identity during amphibian limb regeneration

 Timothy J. Duerr, Melissa Miller, Sage Kumar, Dareen Bakr, Jackson R. Griffiths, Aditya K. Gautham, Danielle Douglas, S. Randal Voss, James R. Monaghan

Post-eclosion growth in the Drosophila Ejaculatory Duct is driven by Juvenile Hormone signaling and is essential for male fertility

Navyashree A Ramesh, Allison M. Box, Laura Buttitta

Eomes directs the formation of spatially and functionally diverse extra-embryonic hematovascular tissues

Bart Theeuwes, Luke TG Harland, Alexandra Bisia, Ita Costello, Mai-Linh Ton, Tim Lohoff, Stephen J Clark, Ricard Argelaguet, Nicola K Wilson, Wolf Reik, Elizabeth Bikoff, Elizabeth J Robertson, Berthold Gottgens

ETS TRANSCRIPTION FACTOR POINTED CONTROLS GERMLINE SURVIVAL IN DROSOPHILA

Alicia E. Rosales-Nieves, Miriam Marín-Menguiano, Lourdes López-Onieva, Juan Garrido-Maraver, Acaimo González-Reyes

Blastocoel expansion and AMOT degradation cooperatively promote YAP nuclear localization during epiblast formation

Hinako Maeda, Hiroshi Sasaki

Mycn regulates vascular development through PI3K signaling pathway in zebrafish

Guo-Qin Zhao, Tao Cheng, Peng-Yun Wang, Jing Mo, Feng Yu, Yang Dong, Yun-Fei Li, Yu Feng, Peng-Fei Xu, Li-Ping Shu

NOTCH-driven oscillations control cell fate decisions during intestinal homeostasis

 View ORCID ProfileSonja D. C. Weterings, Hiromune Eto, Jan-Daniël de Leede, Amir Giladi, Mirjam E. Hoekstra, Wouter F. Beijk, Esther J. M. Liefting, Karen B. van den Anker, Jacco van Rheenen, Alexander van Oudenaarden, Katharina F. Sonnen

Canonical Wnt signalling from the Area Opaca induces and maintains the Marginal Zone in pre-primitive-streak stage chick embryos

 View ORCID ProfileYara Fadaili, Hui-Chun Lu, Hyung Chul Lee, Amra Ryazapova, Claudio D. Stern

Effects Of Aryl Hydrocarbon Receptor Ligand TCDD On Human Trophoblast Cell Development

 View ORCID ProfileVinay Shukla, Khursheed Iqbal, Hiroaki Okae, Takahiro Arima, Michael J. Soares

Comprehensive profiling of migratory primordial germ cells reveals niche-specific differences in non-canonical Wnt and Nodal-Lefty signaling in anterior vs posterior migrants

 View ORCID ProfileRebecca Garrett Jaszczak, Jay W Zussman, Daniel E Wagner, Diana J Laird

| Morphogenesis & mechanics

Material Properties Of The Embryonic Small Intestine During Buckling Morphogenesis

Jenny Gao, Lucia Martin, Elise A. Loffet, John F. Durel, Panagiotis Oikonomou, Nandan L. Nerurkar

BMP signalling attenuates intercellular adhesion to drive mesenchyme migration during fin fold morphogenesis

Bitan Saha, Harsha Mahabaleshwar, Charmaine Ho Min, Leslie Boon Haw Leong, Levene Wenqian Chua, Samuel Kwok, Tom J Carney

Morphogenic, molecular, and cellular adaptations for unidirectional airflow in the chicken lung

Kamryn N Gerner-Mauro, Lisandra Vila Ellis, Guolun Wang, Richa Nayak, Peter Y Lwigale, Ross A Poché, Jichao Chen

Mll4 regulates tooth enamel development

Jung-Mi Lee, Hunmin Jung, Qinghuang Tang, Woojung An, Soo-Kyung Lee, Jae W. Lee, Yungki Park, Hyuk-Jae Edward Kwon

Developmental control of E-cadherin junctions by mechanical contractility in Drosophila embryos

Na Zhang, Wangfang Liu, Huiying Lu, Matthias Haering, Fred Wolf, Joerg Grosshans, Zhiyi Lv, Deqing Kong

Mast cells are not essential for pubertal mammary gland branching.

Simran Kapoor, Jimmy Marsden, Clara M Munz, Cyril Carvalho, Marlene Magalhaes Pinto, Bert Malengier-Devlies, Solvig Becker, Guillaume Seuzaret, Katelyn Patatsos, Ramazan Akyol, Marc DALOD, Amy B Pedersen, Gillian J Wilson, Rebecca Gentek

| Genes & genomes

PROSER1 Modulates DNA Demethylation through Dual Mechanisms to Prevent Syndromic Developmental Malformations

Anna Fleming, Elena V. Knatko, Xiang Li, Ansgar Zoch, Zoe Heckhausen, Stephanie Stransky, Alejandro J. Brenes, Simone Sidoli, Petra Hajkova, Dónal O’Carroll, Kasper D. Rasmussen

Members of an array of zinc finger proteins specify distinct Hox chromatin boundaries

Havva Ortabozkoyun, Pin-Yao Huang, Edgar Gonzalez-Buendia, Hyein Cho, Sang Y. Kim, Aristotelis Tsirigos, Esteban O. Mazzoni, Danny Reinberg

Structural perturbation of chromatin domains with multiple developmental regulators can severely impact gene regulation and development

Shreeta Chakraborty, Nina Wenzlitschke, Matthew J. Anderson, Ariel Eraso, Manon Baudic, Joyce J. Thompson, Alicia A. Evans, Lilly M. Shatford‑Adams, Raj Chari, Parirokh Awasthi, Ryan K. Dale, Mark Lewandoski, Timothy J. Petros, Pedro P. Rocha

Temporally restricted activities of En1 regulatory elements underlie distinct limb malformations

Alessa R. Ringel, Andreas Magg, Natalia Benetti, Robert Schöpflin, Mira Kühnlein, Asita Carola Stiege, Ute Fischer, Lars Wittler, Stephan Lorenz, Stefan Mundlos, Lila Allou

Mechanistic basis of lineage restriction

Bohou Wu, Jae Hyun Lee, Kara M. Foshay, Li Zhang, Croydon J. Fernandes, Boyang Gao, Xiaoyang Dou, Chris Z. Zhang, Guoping Fan, Becky X. Xiao, Bruce T. Lahn

A sperm-enriched 5’fragment of tRNA-Valine regulates preimplantation embryonic transcriptome and development

Simeiyun Liu, Andrew D. Holmes, Sol Katzman, Upasna Sharma

Chromatin remodeler CHD4 establishes chromatin states required for ovarian reserve formation, maintenance, and germ cell survival

Yasuhisa Munakata, Mengwen Hu, Yuka Kitamura, Adam L Bynder, Amelia S Fritz, Richard M Schultz, Satoshi H Namekawa

Diverse somatic Transformer and sex chromosome karyotype pathways regulate gene expression in Drosophila gonad development

Sharvani Mahadevaraju, Soumitra Pal, Pradeep Bhaskar, Brennan D. McDonald, Leif Benner, Luca Denti, Davide Cozzi, Paola Bonizzoni, Teresa M. Przytycka, Brian Oliver

A newly evolved gene is essential for efficient sperm entry into eggs in Drosophila melanogaster

Sara Y. Guay, Prajal H. Patel, Jonathon M. Thomalla, Kerry L. McDermott, Jillian M. O’Toole, Sarah E. Arnold, Sarah J. Obrycki, Mariana F. Wolfner, Geoffrey D. Findlay

Mechanistic origin and preimplantation development of uniparental and polyploid blastomeres

Yan Zhao, Andrea Fernández-Montoro, Greet Peeters, Tatjana Jatsenko, Tine De Coster, Daniel Angel-Velez, Thomas Lefevre, Thierry Voet, Olga Tšuiko, Ants Kurg, Katrien Smits, Ann Van Soom, Joris Robert Vermeesch

Dynamic Wt1 expression in the gastrulation-stage mouse embryo specifies vascular and visceral smooth muscle cell fate independently from mesothelial fate.

Suad Hassan Alsukari, Huei Teng Ng, Lilly Lang, Sharna Lunn, Shanthi Beglinger, Lauren Carr, Michael Boyes, David Andrew Turner, Bettina Wilm

The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression patterns through regulation of WDR5 stability

Huishan Wang, Xingyan Liu, Yamin Liu, Chencheng Yang, Yaxin Ye, Xiaomei Yu, Nengyin Sheng, Shihua Zhang, Bingyu Mao, Pengcheng Ma

Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation

Mehmet Mahsum Kaplan, Erika Hudacova, Miroslav Matejcek, Haneen Tuaima, Jan Krivanek, Ondrej Machon

Neuronal progenitors suffer genotoxic stress in the Drosophila clock mutant per0

Nunzia Colonna Romano, Marcella Marchetti, Anna Marangoni, Laura Leo, Diletta Retrosi, Ezio Rosato, Laura Fanti

Mutations in ErbB2 accumulating in the male germline measured by error-corrected sequencing

Atena Yasari, Monika Heinzl, Theresa Mair, Tina Karimian, Shehab Moukbel Ali Aldawla, Ingrid Hartl, Andrea J. Betancourt, Peter Lanzerstorfer, Irene Tiemann-Boege

Traffic Jam activates the Flamenco piRNA cluster locus and the Piwi pathway to ensure transposon silencing and Drosophila fertility

Austin Rivera, Jou-Hsuan Roxie Lee, Shruti Gupta, Linda Yang, Raghuveera Kumar Goel, Joseph Zaia, Nelson C. Lau

The Transcription Factor TCF21 is necessary for adoption of cell fates by Foxd1+ stromal progenitors during kidney development

Gal Finer, Mohammad D. Khan, Yalu Zhou, Gaurav Gadhvi, George S. Yacu, Joo-Seop Park, R. Ariel Gomez, Maria Luisa Sequeira-Lopez, Susan E. Quaggin, Deborah R. Winter

Fate specification triggers a positive feedback loop of TEAD–YAP and NANOG to promote epiblast formation in preimplantation embryos

Naoki Hirono, Masakazu Hashimoto, Hinako Maeda, Hiromi Shimojo, Hiroshi Sasaki

Distinct checkpoint and homolog biorientation pathways regulate meiosis I in Drosophila oocytes

Joanatta G. Shapiro, Neha Changela, Janet K. Jang, Jay N. Joshi, Kim S. McKim

A whole-organism landscape of X-inactivation in humans

Björn Gylemo, Maike Bensberg, Colm E. Nestor

Epigenetic and transcriptional regulation of ovarian development altered in ErβKO ovaries

Ryan Mohamadi, Kevin Vo, Yashica Sharma, Amelia Mohamadi, Elizabeth S. Bahadursingh, Patrick E. Fields, M. A. Karim Rumi

Castor is a temporal transcription factor that specifies early born central complex neuron identity

Noah R. Dillon, Chris Q. Doe

Dynamic convergence of autism disorder risk genes across neurodevelopment

Meilin Fernandez Garcia, Kayla Retallick-Townsley, April Pruitt, Elizabeth Davidson, Yi Dai, Sarah E. Fitzpatrick, Annabel Sen, Sophie Cohen, Olivia Livoti, Suha Khan, Grace Dossou, Jen Cheung, P.J. Michael Deans, Zuoheng Wang, Laura Huckins, Ellen Hoffman, Kristen Brennand

H3K4me2 distinguishes a distinct class of enhancers during the maternal-to-zygotic transition

Matthew D. Hurton, Jennifer M. Miller, Miler T. Lee

Early Hox Gene Expression in Echinoderms

 Olga V. Ezhova, Natalya V. Ageenko, Konstantin V. Kiselev, Anastasiya I. Lukinykh, Vladimir V. Malakhov

A sperm-enriched 5’fragment of tRNA-Valine regulates preimplantation embryonic transcriptome and development

Simeiyun Liu, Andrew D. Holmes, Sol Katzman, Upasna Sharma

A master regulatory loop that activates genes in a temporally coordinated manner in muscle cells of ascidian embryos

Izumi Oda, Yutaka Satou

The Transcription Factor TCF21 is necessary for adoption of cell fates by Foxd1+ stromal progenitors during kidney development

Gal Finer, Mohammad D. Khan, Yalu Zhou, Gaurav Gadhvi, George S. Yacu, Joo-Seop Park, R. Ariel Gomez, Maria Luisa Sequeira-Lopez, Susan E. Quaggin, Deborah R. Winter

Differential regulation of eye specification in Drosophila by Polycomb Group (PcG) epigenetic repressors

Haley E. Brown, Brandon P. Weasner, Justin P. Kumar

A dual ribosomal system in the zebrafish soma and germline

Arish N Shah, Friederike Leesch, Laura Lorenzo-Orts, Lorenz Grundmann, Maria Novatchkova, David Haselbach, Eliezer Calo, Andrea Pauli

| Stem cells, regeneration & disease modelling

The transcription factor Chronophage/BCL11A/B promotes intestinal stem cell proliferation and endocrine differentiation in the Drosophila intestine

Emer Aisling King, Eleanor Jacobsen, Nicholas Woolner, Joaquín de Navascués, Owen J Marshall, Jerome Korzelius

PDK-1/S6K and mTORC1 bypass systemic growth restrictions to promote regeneration

Ananthakrishnan Vijayakumar Maya, Liyne Nogay, Lara Heckmann, Isabelle Grass, Katrin Kierdorf, Jörg Büscher, Anne-Kathrin Classen

Canonical and non-canonical PRC1 differentially contribute to the regulation of neural stem cell fate

Janine Hoffmann, Theresa M. Schütze, Annika Kolodziejczyk, Annekathrin Kränkel, Susanne Reinhardt, Razvan P. Derihaci, Cahit Birdir, Pauline Wimberger, Haruhiko Koseki, Mareike Albert

Serotonin neuromodulation directs optic nerve regeneration

 Kristian Saied-Santiago, Melissa Baxter, Jaffna Mathiaparanam, Michael Granato

Compound screening in primary human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies

Yuki Ishii, Jessica C. Orr, Marie-Belle El Mdawar, Denise R. Bairros de Pilger, David R. Pearce, Kyren A. Lazarus, Rebecca E. Graham, Marko Z. Nikolic, Robin Ketteler, Neil O. Carragher, Sam M. Janes, Robert E. Hynds

A Sox2 Enhancer Cluster Regulates Region-Specific Neural Fates from Mouse Embryonic Stem Cells

Ian C Tobias, Sakthi D Moorthy, Virlana M Shchuka, Lida Langroudi, Mariia Cherednychenko, Zoe E Gillespie, Andrew G Duncan, Ruxiao Tian, Natalia A Gajewska, Raphaël B Di Roberto, Jennifer A Mitchell

The level of HAND1 controls the specification of multipotent cardiac and extraembryonic progenitors

Adam T Lynch, Naomi Phillips, Megan Douglas, Marta Dorgnach, I-Hsuan Lin, Antony D Adamson, Zoulfia Darieva, Jessica Whittle, Neil A Hanley, Nicoletta Bobola, Matthew J Birket

The microbiota affects stem cell decision making in Hydra

Jinru He, Alexander Klimovich, Sabine Kock, Linus Dahmke, Sören Franzenburg, Thomas C.G. Bosch

Proliferative events ameliorate DNA damage accumulation without affecting function in hematopoietic stem cells

Shubham Haribhau Mehatre, Harsh Agrawal, Irene Mariam Roy, Sarah Schouteden, Satish Khurana

Appendage regeneration requires IMPDH2 and creates a sensitized environment for enzyme filament formation

Morgan E. McCartney, Gavin M. Wheeler, Audrey G. O’Neill, Jeet H. Patel, Zoey R. Litt, S. John Calise, Justin M. Kollman, Andrea E. Wills

Chromatin activity of IκBα mediates the exit from naïve pluripotency

Luis G. Palma, Daniel Álvarez-Villanueva, María Maqueda, Mercedes Barrero, Arnau Iglesias, Joan Bertran, Damiana Álvarez-Errico, Carlos A. García-Prieto, Cecilia Ballaré, Virginia Rodriguez-Cortez, Clara Bueno, August Vidal, Alberto Villanueva, Pablo Menéndez, Gregoire Stik, Luciano Di Croce, Bernhard Payer, Manel Esteller, Lluís Espinosa, Anna Bigas

Voltage-gated calcium channels generate blastema Ca2+ fluxes restraining zebrafish fin regenerative outgrowth

Heather K. Le Bleu, Rea G. Kioussi, Astra L. Henner, Victor M. Lewis, Scott Stewart, Kryn Stankunas

FGF9 treatment reduces off-target chondrocytes from iPSC-derived kidney organoids

Virginie Joris, Anika Schumacher, Paula Marks, Maria Eischen-Loges, Martijn van Griensven, Vanessa L.S. LaPointe

Transcriptomic analysis and high throughput functional characterization of human induced pluripotent stem cell derived sensory neurons

Vincent Truong, Jackson Brougher, Tim Strassmaier, Irene Lu, Dale George, Theodore J. Price, Alison Obergrussberger, Aaron Randolph, Rodolfo J. Haedo, Niels Fertig, Patrick Walsh

Mitochondrial activity-driven hematopoietic stem cell fate and lympho-myeloid lineage choice is first established in the aorta-gonad-mesonephros

Aishwarya Prakash, Maneesha S. Inamdar

Readaptation of mesenchymal stem cells to high stiffness and oxygen environments modulate the extracellular matrix

Inês Caramelo, Catarina Domingues, Vera M. Mendes, Sandra I. Anjo, Margarida Geraldo, Carla M. P. Cardoso, Mário Grãos, Bruno Manadas

Metadichol induces CD14 Glycoprotein Expression in Human Embryonic Stem Cells and Fibroblasts

P. R. Raghavan

Nuclear actin is a critical regulator of Drosophila female germline stem cell maintenance

Nicole M. Green, Danielle Talbot, Tina L. Tootle

Survival of hepatocytes from executioner caspase activation promotes liver regeneration by enhancing JAK/STAT3 activity

Zhiyuan Cao, Lining Qin, Kaixuan Liu, Chen Yao, Enhong Li, Xiaoyu Hao, Molin Wang, Baichun Jiang, Yongxin Zou, Huili Hu, Qiao Liu, Changshun Shao, Yaoqin Gong, Gongping Sun

Posterior specification of multi-lineage axial assembloids from human pluripotent stem cells.

Nigel Kee, Mélanie Leboeuf, Silvia Gómez, Charles Petipré, Irene Mei, Salim Benlefki, Daniel W Hagey, José Dias, François Lallemend, Samir EL Andaloussi, Johan Ericson, Eva Hedlund

| Plant development

snRNA-seq analysis of the moss Physcomitrium patens reveals a conserved cytokinin-ESR module promoting pluripotent stem cell identity

Yuki Hata, Nicola Hetherington, Kai Battenberg, Atsuko Hirota, Aki Minoda, Makoto Hayashi, Junko Kyozuka

Knockout of the tomato HAIRY MERISTEM 4 alters phloem-characteristics and impairs development

Jackson Khedia, Abhay Pratap Vishwakarma, Ortal Galsurker, Shira Corem, Suresh Kumar Gupta, Tzahi Arazi

The contrasting flowering-time among coffee genotypes is associated with ectopic and differential expressions of genes related to environment, floral development, and hormonal regulation

Marlon Enrique López, Raphael Ricon de Oliveira, Lillian Magalhães Azevedo, Iasminy Silva Santos, Thales Henrique Cherubino Ribeiro, Dapeng Zhang, Antonio Chalfun-Junior

Physiological and Molecular Responses of Projected Future Temperatures on Potato Tuberization

Abigail M. Guillemette, Guillian Hernández Casanova, John P. Hamilton, Eva Pokorná, Petre I. Dobrev, Václav Motyka, Aaron M. Rashotte, Courtney P. Leisner

Genome sequence of the ornamental plant Digitalis purpurea reveals the molecular basis of flower color and morphology variation

Jakob Maximilian Horz, Katharina Wolff, Ronja Friedhoff, Boas Pucker

Single-nucleus transcriptomics resolves differentiation dynamics between shoot stem cells and primary stem

Sebastián R. Moreno, Martin O. Lenz, Elliot M Meyerowitz, James CW Locke, Henrik Jönsson

A cell fractionation and quantitative proteomics pipeline to enable functional analyses of cotton fiber development

Youngwoo Lee, Heena Rani, Eileen L. Mallery, Daniel B Szymanski

Viral delivery of an RNA-guided genome editor for transgene-free germline editing in Arabidopsis

Trevor Weiss, Maris Kamalu, Honglue Shi, Zheng Li, Jasmine Amerasekera, Zhenhui Zhong, Benjamin A Adler, Michelle Song, Kamakshi Vohra, Gabriel Wirnowski, Sidharth Chitkara, Charlie Ambrose, Noah Steinmetz, Ananya Sridharan, Diego Sahagun, Jill Banfield, Jennifer Doudna, Steven E. Jacobsen

Natural variation suggests new mechanisms for bract development in Arabidopsis, desynchronising bract suppression from the floral transition

Sana Dieudonne Dr., Ruth Kristianingsih Ms, Stephanie Laine Ms, Beline JESSON Ms, Veronique VIDAL Ms, Rachel Wells Dr., Richard Morris Pr., Fabrice Besnard Dr.

MAC3A and MAC3B modulate FLM splicing to repress photoperiod-dependent floral transition

Yu-Wen Huang, Chih-Yen Tseng, Yi-Tsung Tu, Hsin-Yu Hsieh, Yu-Sen Wang, Yun-Tung Ly, Yu-Zhen Chen, Shih-Long Tu, Chin-Mei Lee

Conserved role of the SERK–BIR module in development and immunity across land plants

Yijia Yan, Jaqueline Mellüh, Martin A. Mecchia, Hyung-Woo Jeon, Katharina Melkonian, Clemens Holzberger, Anne Harzen, Sara Christina Stolze, Rainer Franzen, Yuki Hirakawa, Ana I. Caño Delgado, Hirofumi Nakagami

A leaf-expressed TERMINAL FLOWER1 ortholog from coffee with alternate splice forms alters flowering time and inflorescence branching in Arabidopsis

 Carlos Henrique Cardon, Victoria Lesy, Catherine Fust, Thales Henrique Cherubino Ribeiro, Owen Hebb, Raphael Ricon de Oliveira, Mark Minow, Antonio Chalfun Junior, Joseph Colasanti

Two distinct oscillatory auxin signals define the plasticity of lateral rooting in Arabidopsis thaliana

Chengzhi Ren, Jule Bodendorf, Jurgen Kleine-Vehn

Natural alleles of LEAFY and WAPO1 interact to regulate spikelet number per spike in wheat

Junli Zhang, German F Burguener, Francine Paraiso, Jorge Dubcovsky

Developmental variability in cotton fiber cell wall properties linked to important agronomic traits

Michael C Wilson, Alexander H Howell, Anika Sood, Youngwoo Lee, Pengcheng Yang, Heena Rani, Elena Yu, Eileen L. Mallery, Sivakumar Swaminathan, Corrinne E. Grover, Jonathan F. Wendel, Olga A. Zabotina, Jun Xie, Chelsea S. Davis, Daniel Szymanski

Flower bud cooling protects pollen development and improves fertility during heatwaves

Martijn J. Jansen, Stuart Y. Jansma, Klaske M. Kuipers, Wim H. Vriezen, Frank F. Millenaar, Teresa Montoro, Carolien G.F. de Kovel, Fred A. van Eeuwijk, Eric J.W. Visser, Ivo Rieu

Assessing male reproductive investment in Papaveraceae using flow cytometry reveals lineage-specific trajectories to pollen-to-ovule ratio reduction

Jurriaan M. de Vos, Yannick Woudstra, Ilia J. Leitch, Oriane Hidalgo

The three-dimensional anatomy and dorsoventral asymmetry of the mature Marchantia polymorpha meristem develops from a symmetrical gemma meristem

Victoria Spencer, Eva-Sophie Wallner, Katharina Jandrasits, Natalie Edelbacher, Magdalena Mosiolek, Liam Dolan

OsWHY1/OsTRXz/OsMORFs complex is essential for RNA modification and early chloroplast development in rice

Xiangzi Zheng, Qingzheng Lu, Yuling Luo, Jiaxuan Xu, Weiqi Wang, Min Tan, Dongmei Liao, Wuqiang Hong, Sirong Chen, Chuheng Lin, Xiaoli Wang, Chunlan Fan, Habiba, Xiaowei Wang, Yanyun Li, Yu Zhang, Wenfang Lin, Ying Miao

Transcriptomic dynamics of petal development in the one-day flower species, Japanese morning glory (Ipomoea nil)

Soya Nakagawa, Atsushi Hoshino, Kazuyo Ito, Hiroyo Nishide, Katsuhiro Shiratake, Atsushi J Nagano, Yasubumi Sakakibara

Guard-cell phytosterol homeostasis is critical for proper stomatal development

Chih-Chung Yen, Ya-Wen Hsu, Kuan-Chieh Leu, Sheau-Shyang Chen, Tzu-Yun Chen, Chien-Ta Juan, Chi Kuan, Jei-Fu Shaw, Chin-Min Kimmy Ho, Guang-Yuh Jauh

The receptor-like kinase ALE2 promotes giant cell formation in the sepal epidermis

Frances K Clark, Jessica McGory, Nicholas Russell, Pau Formosa-Jordan, Adrienne H. K. Roeder

Multi-scale dynamics influence the division potential of stomatal lineage ground cells in Arabidopsis

Hannah F. Fung, Gabriel O. Amador, Renee Dale, Yan Gong, Macy Vollbrecht, Joel M. Erberich, Andrea Mair, Dominique C. Bergmann

| Evo-devo

Reverse development in the ctenophore Mnemiopsis leidyi

Joan J. Soto-Angel, Pawel Burkhardt

Protein degradation shapes developmental tempo in mouse and human neural progenitors

Shota Nakanoh, Despina Stamataki, Lorena Garcia-Perez, Chiara Azzi, Hayley L Carr, Alexandra Pokhilko, Lu Yu, Steven Howell, Mark Skehel, David Oxley, Simon Andrews, James Briscoe, Teresa Rayon

A punctuated burst of massive genomic rearrangements and the origin of non-marine annelids

Carlos Vargas-Chávez, Lisandra Benítez-Álvarez, Gemma I. Martínez-Redondo, Lucía Álvarez-González, Judit Salces-Ortiz, Klara Eleftheriadi, Nuria Escudero, Nadège Guiglielmoni, Jean-François Flot, Marta Novo, Aurora Ruiz-Herrera, Aoife McLysaght, Rosa Fernández

Developmental plasticity and genetic selection shaped cereal evolution in the Early Holocene southern Levant

Jade Whitlam, Pascal Flohr, Amy Bogaard, Mike Charles, Bill Finlayson, Cheryl A. Makarewicz

A c-opsin functions in a ciliary-marginal zone-like stem cell region of an invertebrate camera-type eye

Nadja Milivojev, Camila L. Velastegui Gamboa, Gabriele Andreatta, Florian Raible, Kristin Tessmar-Raible

Mammalian retinal specializations for high acuity vision evolve in response to both foraging strategies and morphological constraints

Emily E. K. Kopania, Nathan L. Clark

Microglia cannibalism and efferocytosis leads to shorter lifespans of developmental microglia

Hannah Gordon, Zachary Schafer, Cody J. Smith

Functional divergence of conserved developmental plasticity genes between two distantly related nematodes

Sara Wighard, Hanh Witte, Ralf J. Sommer

Less, but more: new insights from appendicularians on chordate Fgf evolution and the divergence of tunicate lifestyles

Gaspar Sánchez-Serna, Jordi Badia-Ramentol, Paula Bujosa, Alfonso Ferrández-Roldán, Nuria P. Torres-Águila, Marc Fabregà-Torrus, Johannes N. Wibisana, Michael J. Mansfield, Charles Plessy, Nicholas M. Luscombe, Ricard Albalat, Cristian Cañestro

Cell Biology

Polo-like kinase 1 prevents excess microtubule polymerization in C. elegans oocytes to ensure faithful meiosis

Juhi G. Narula, Sarah M. Wignall

Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation

Huanhuan Liu, Anupama Binoy, Siqi Ren, Thomas C. Martino, Anna E. Miller, Craig R. G. Willis, Shivakumar R. Veerabhadraiah, Abhijit Sukul, Joanna Bons, Jacob P. Rose, Birgit Schilling, Michael J. Jurynec, Shouan Zhu

Actin dynamics switches two distinct modes of endosomal fusion in yolk sac visceral endoderm cells

Seiichi Koike, Masashi Tachikawa, Motosuke Tsutsumi, Takuya Okada, Tomomi Nemoto, Kazuko Keino-Masu, Masayuki Masu

A maternally inherited Chromosomal Passenger Complex regulates germ plasm ribonucleoparticle aggregation in Zebrafish

Cara Moravec, Francisco Pelegri

AalpiRNA-18529 regulates vitellogenesis of Aedes albopictus via the Gadd45a-mediated JNK-dependent nurse cell apoptosis pathway

Lu Yang, Yonghui Gao, Yulan Chen, Shuyi Ren, Yifan Guo, Peiwen Liu, Khadija Batool, Jianxia Tang, Jinbao Gu

Versatile gamma-tubulin complexes contribute to the dynamic organization of MTOCs during Drosophila spermatogenesis

Elham Alzyoud, Dóra Németh, Viktor Vedelek, Titanilla Szögi, Viktória Petra Tóth, Mónika Krecsmarik, Edit Ábrahám, Zoltán Lipinszki, Rita Sinka

Proteome asymmetry in mouse and human embryos before fate specification

Lisa K. Iwamoto-Stohl, Aleksandra A. Petelski, Maciej Meglicki, Audrey Fu, Saad Khan, Harrison Specht, Gray Huffman, Jason Derks, Victoria Jorgensen, Bailey A.T. Weatherbee, Antonia Weberling, Carlos W. Gantner, Rachel S. Mandelbaum, Richard J. Paulson, Lisa Lam, Ali Ahmady, Estefania Sanchez Vasquez, Nikolai Slavov, Magdalena Zernicka-Goetz

The PIDDosome controls cardiomyocyte polyploidization during postnatal heart development

M Leone, N Kinz, F Eichin, D Obwegs, VC Sladky, D Rizzotto, C Manzl, K Moos, ED Jacotot, C Savko, MA Sussman, M Boerries, A Villunger

Erythropoietin-dependent Acquisition of CD71hiCD105hi Phenotype within CD235a- Early Erythroid Progenitors

Natascha Schippel, Jing Wei, Xiaokuang Ma, Mrinalini Kala, Shenfeng Qiu, Peter Stoilov, Shalini Sharma

Sustained fertility from first-wave follicle oocytes that pause their growth

Bikem Soygur, Eliza A. Gaylord, Mariko H. Foecke, Steven A. Cincotta, Tegan S. Horan, Anna Wood, Paula E. Cohen, Diana J. Laird

Modelling

Physical modeling of embryonic transcriptomes identifies collective modes of gene expression

 Dominic J. Skinner, Patrick Lemaire, Madhav Mani

Computing hematopoietic stem and progenitor cell plasticity in response to genetic mutations and environmental stimulations

Yuchen Wen, Hang He, Yunxi Ma, Lorie Chen Cai, Huaquan Wang, Yanmei Li, Baobing Zhao, Zhigang Cai

Spatial model of cell-fate choice uncovers strong links between tissue morphology and tissue regeneration

Somya Mani, Tsvi Tlusty

Role of Data-driven Regional Growth Model in Shaping Brain Folding Patterns

Jixin Hou, Zhengwang Wu, Xianyan Chen, Dajiang Zhu, Tianming Liu, Gang Li, Xianqiao Wang

A Computational Framework for Modeling Emergence of Color Vision in the Human Brain

Atsunobu Kotani, Ren Ng

Streamline tractography of the fetal brain in utero with machine learning

Weide Liu, Camilo Calixto, Simon K. Warfield, Davood Karimi

Multiple Notch ligands in the synchronization of the segmentation clock

Marcos Wappner, Koichiro Uriu, Andrew C. Oates, Luis G. Morelli

Tools & Resources

Silk-Ovarioids: Establishment and characterization of human ovarian primary cells 3D-model system

Valentina Di Nisio, Tianyi Li, Zhijie Xiao, Kiriaki Papaikonomou, Anastasios Damdimopoulos, Ákos Végvári, Filipa Lebre, Ernesto Alfaro-Moreno, Mikael Pedersen, Terje Svingen, Roman Zubarev, Ganesh Acharya, Pauliina Damdimopoulou, Andres Salumets

Phylogeny, morphology, and behavior of the new ciliate species Stentor stipatus

D. Rajan, B. Lee, A. Albright, E. Tang, A. Maravillas, C. Vargas, W. F. Marshall, D. Cortes

CRISPR-Cas13d as a molecular tool to achieve targeted gene expression knockdown in chick embryos

Minyoung Kim, Erica J. Hutchins

Compatibility of time-lapse dry incubator on in vitro production of bovine embryos

Haruhisa Tsuji, Hiroki Nagai, Sayaka Kobinata, Hinata Koyama, Atchalalt Khurchabilig, Noritaka Fukunaga, Yoshimasa Asada, Satoshi Sugimura

A transgene-free, human peri-gastrulation embryo model with trilaminar embryonic disc-, amnion- and yolk sac-like structures

Shiyu Sun, Yi Zheng, Yung Su Kim, Zheng Zhong, Norio Kobayashi, Xufeng Xue, Yue Liu, Zhuowei Zhou, Yanhong Xu, Jinglei Zhai, Hongmei Wang, Jianping Fu

Morphological criteria for staging near-hatching embryos of the domesticated Mallard (Anas platyrhynchos) and Swan Goose (Anser cygnoides)

 Bassel Arnaout, Kaylen Brzezinski, Benjamin Steventon, Daniel J. Field

Three-dimensional culture in a bioengineered matrix and somatic cell complementation to improve growth and survival of bovine preantral follicles

 Juliana I. Candelaria, Ramon C. Botigelli, Carly Guiltinan, Ariella Shikanov, Anna C. Denicol

Centimeter-scale, physiologically relevant intestinal organoids generated entirely from pluripotent stem cells

Zhen Qi, Zhanguang Zuo, Yi Dong, Jingyu Shao, Chong Wang, Rosanna Zhang

A human induced pluripotent stem (hiPS) cell model for the holistic study of epithelial to mesenchymal transitions (EMTs)

Caroline Hookway, Antoine Borensztejn, Leigh K. Harris, Sara Carlson, Gokhan Dalgin, Suraj Mishra, Nivedita Nivedita, Ellen M. Adams, Tiffany Barszczewski, Julie C. Dixon, Jacqueline H. Edmonds, Erik A. Ehlers, Alexandra J. Ferrante, Margaret A. Fuqua, Philip Garrison, Janani Gopalan, Benjamin W. Gregor, Maxwell J. Hedayati, Kyle N. Klein, Chantelle L. Leveille, Sean L. Meharry, Haley S. Morris, Gouthamrajan Nadarajan, Sandra A. Oluoch, Serge E. Parent, Amber Phan, Brock Roberts, Emmanuel E. Sanchez, M. Filip Sluzewski, Lev S. Snyder, Derek J. Thirstrup, John Paul Thottam, Julia R. Torvi, Gaea Turman, Matheus P. Viana, Lyndsay Wilhelm, Chamari S. Wijesooriya, Jie Yao, Julie A. Theriot, Susanne M. Rafelski, Ruwanthi N. Gunawardane

A simple inland culture system provides insights into ascidian post-embryonic developmental physiology

Birthe Thuesen Mathiesen, Mayu Ohta, Boris Pinto De Magalhaes, Chiara Castelletti, Vincenzo Perria, Lionel Christiaen, Naoyuki Ohta

Three-dimension transcriptomics maps of whole mouse embryo during organogenesis

Mengnan Cheng, Huiwen Zheng, Qi Fang, Yinqi Bai, Chao Liu, Hailin Pan, Zhewei Zhang, Qin Lu, Chang Shi, Tianyi Xia, Zehua Jing, Huanlin Liu, Ning Feng, Guojun Fu, Yumei Li, Jing Feng, Zepeng Li, Jingjing Wang, Yuanyuan Chen, Lianying Wang, Zhonghan Deng, Mei Li, Longqi Liu, Ao Chen, Xun Xu

A Human Biomimetic Intestinal Mucosa Model to Study Gastrointestinal Development and Disease

Alessandro Dei, Carlemi Calitz, Joep Korsten, Nina Johannesson, Eline Freeze, Allen Eaves, John Stingl, Ryan K Condor, Wing Chang, Dasja Pajkrt, Katja C. Wolthers, Adithya Sridhar, Salvatore Simmini

Moult cycle and setal development of the Atlantic ditch shrimp Palaemon varians Leach, 1814

Kenneth Kim, Jonathan Antcliffe, Allison C. Daley, Marc Robinson-Rechavi

Whole-embryo Spatial Transcriptomics at Subcellular Resolution from Gastrulation to Organogenesis

Yinan Wan, Jakob El Kholtei, Ignatius Jenie, Mariona Colomer-Rosell, Jialin Liu, Joaquin Navajas Acedo, Lucia Y. Du, Mireia Codina-Tobias, Mengfan Wang, Ahilya Sawh, Edward Lin, Tzy-Harn Chuang, Susan E. Mango, Guoqiang Yu, Bogdan Bintu, Alexander F. Schier

Dissecting the regulatory logic of specification and differentiation during vertebrate embryogenesis

Jialin Liu, Sebastian M. Castillo-Hair, Lucia Y. Du, Yiqun Wang, Adam N. Carte, Mariona Colomer-Rosell, Christopher Yin, Georg Seelig, Alexander F. Schier

A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate

Eric R. Brooks, Andrew R. Moorman, Bhaswati Bhattacharya, Ian Prudhomme, Max Land, Heather L. Alcorn, Roshan Sharma, Dana Pe’er, Jennifer A. Zallen

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