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developmental and stem cell biologists
Posted by the Node Interviews, on 24 October 2018
The construction of complex three-dimensional tissue structures during embryogenesis requires precise control of cell and tissue mechanics. The Xenopus embryo provides a powerful tool for interrogating this relationship, as demonstrated ...Posted by the Node Interviews, on 21 September 2018
During early mouse development, a series of signalling interactions breaks the symmetry of the egg cylinder, spatially organising the embryo into territories that define the future axes of the body. ...Posted by the Node Interviews, on 4 September 2018
Axon guidance relies on the reception and integration of molecular cues from the environment by growth cones, and defective pathfinding results in misplaced projection patterns in the mature nervous system. ...Posted by the Node Interviews, on 9 August 2018
The neural crest is a progenitor population with the capacity to contribute to all vertebrate germ layers. The transcription factor and signalling pathway activity underlying this remarkable pluripotency have been well ...Posted by the Node Interviews, on 23 July 2018
Parasitic plants are fascinating and agriculturally relevant organisms that rely for their success on the haustorium, a specialised root structure that invades host root vasculature to derive nutrients and water. A ...Posted by the Node Interviews, on 18 July 2018
Asymmetric division is a widespread mechanism for generating cellular diversity during developmental patterning. The stomata of flowering plants are epidermal valves that regulate gas exchange, and provide an accessible system to investigate the mechanisms ...Posted by the Node Interviews, on 6 July 2018
Contact inhibition of locomotion is a widespread phenomenon in migrating cells. However, cells often migrate collectively as a sheet, raising the question of how contact inhibition is overcome in these ...Posted by Nicolas Rivron, on 27 June 2018
In our recently published paper1, we showed that mouse stem cells self-organize into blastocyst-like structures, that we termed blastoids. Because blastoids can be generated in large numbers, can be finely ...Posted by the Node Interviews, on 12 June 2018
Somites are segmented structures which give rise to numerous tissues in the vertebrate body. It has long been observed that somites scale in size with the overall size of the ...Posted by the Node Interviews, on 25 May 2018
Short CLE peptides regulate a wide variety of processes during plant development. In the developing root, the receptors and co-receptors for CLEs have remained largely unclear, as have the relationships ...