Today’s recommended paper is:
Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis
Alexandre R. Colas, Wesley L. McKeithan, Thomas J. Cunningham, et al. (2012)
Genes & Development, published in advance, November 14, 2012
Submitted by Heather Buschman:
“To determine if microRNAs influence germ layer formation in early embryonic development, the authors sequenced the entire mouse genome’s worth of microRNAs in embryonic stem cells. In doing so, they discovered that two microRNA families in particular—let-7 and miR-18—block endoderm formation, but permit mesoderm and ectoderm formation. The authors also went on to pinpoint a mechanism—these microRNAs direct germ layer formation by dampening TGFβ signaling.”
From December 1 to 24 we are featuring Node readers’ favourite papers of the past year. Click the calendar in the side bar each day to see a new paper. To see all papers submitted so far, see the calendar archive.