In Development this week (Vol. 142, Issue 18)

Here are the highlights from the current issue of Development – our Special Issue on “Human Development”. This Special Issue brings together a collection of Reviews and Research Articles that directly address a broad range of topics in human developmental biology: from the earliest stages of human development to cellular ageing and degeneration, and from basic questions of how an organ is formed to ways in which we might translate this knowledge in the clinic. Happy reading!

Enabling research with human embryonic and fetal tissue resources

Gerrelli and colleagues summarise the remit and efforts of the Human Developmental Biology Resource – and other similar projects – that provides researchers with access to human tissue and related services. See the Spotlight article on p. 3073

The advancement of human pluripotent stem cell-derived therapies into the clinic

In their opinion piece, Thies and Murry consider progress in the use of human PSCs in regenerative medicine – fuelled by advances in developmental biology – in five areas that offer great promise for clinical applications. See the Spotlight article on p. 3077

When rejuvenation is a problem: challenges of modeling late-onset neurodegenerative disease

Vera and Studer discuss the difficulties involved in using stem cells to study diseases of the elderly and review how these might be overcome. See the Spotlight article on p. 3085

The pluripotent state in mouse and human

Pera and colleagues examine recent efforts in defining and capturing the human naïve pluripotent state in vivo and in vitro, in light of the different states of pluripotency found in the mouse. See the Review article on p. 3090

Genomic approaches to studying human-specific developmental traits

Franchini and Pollard discuss how genome sequencing and functional genomic approaches are enabling analyses of the evolutionary and developmental origin of traits unique to our species. See the Review article on p. 3100

Modelling mouse and human development using organoid cultures

Huch and Koo review recent advances in the generation of ESC- and adult stem cell-derived organoids in order to understand the development of endoderm-derived organs in human and to develop therapeutic strategies for repair. See the Review article on p. 3113

Human pancreas development

Jennings, Hanley and colleagues present a human-centric view of the latest advances in our understanding of pancreas development and the relevance of these insights from a clinical perspective. See the Review article on p. 3126

Is this a brain which I see before me? Modeling human neural development with pluripotent stem cells

Suzuki and Vanderhaeghen examine stem cell-based approaches to analysing human brain development, from specification of particular cell types to building neuronal networks. See the Review article on p. 3138

PLUS:

Research Articles/Techniques and Resources:

• Defining the three cell lineages of the human blastocyst by single-cell RNA-seq

• Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor

• Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro

• Human epidermal neural crest stem cells as a source of Schwann cells

• Inhibition of β-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes

• Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome

• Interspecific in vitro assay for the chimera-forming ability of human pluripotent stem cells

• Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells

• Quantification of regenerative potential in primary human mammary epithelial cells

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