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developmental and stem cell biologists

January in preprints

Posted by , on 17 February 2022

Welcome to our monthly trawl for developmental biology (and related) preprints.

The preprints this month are hosted on bioRxiv, arXiv and preprints.org – use these links to get to the section you want.

Developmental biology

Cell Biology

Modelling

Reviews

Tools & Resources

Research practice & education

Developmental biology

| Patterning & signalling

Mouse spinal cords from Dahl, et al.

mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system
Kristin D. Dahl, Hannah A. Hathaway, Adam R. Almeida, Jennifer Bourne, Tanya L. Brown, Lisbet T. Finseth, Teresa L. Wood, Wendy B. Macklin

Sufu regulation of Hedgehog signaling is required for proper glial cell differentiation
Danielle M. Spice, Joshua Dierolf, Gregory M. Kelly

Characterization of alveolar epithelial lineage heterogeneity during the late pseudoglandular stage of mouse lung development
Matthew R. Jones, Lei Chong, Arun Reddy Limgapally, Jochen Wilhem, Meshal Ansari, Herbert B. Schiller, Gianni Carraro, Saverio Bellusci

Tiling mechanisms of the compound eye through geometrical tessellation
Takashi Hayashi, Takeshi Tomomizu, Takamichi Sushida, Masakazu Akiyama, Shin-Ichiro Ei, Makoto Sato

A kinase translocation reporter reveals real-time dynamics of ERK activity in Drosophila
Alice C. Yuen, Anadika R. Prasad, Vilaiwan M. Fernandes, Marc Amoyel

Rnf149-related is an FGF/MAPK-independent regulator of pharyngeal muscle fate specification
Burcu Vitrinel, Christine Vogel, Lionel Christiaen

Cell Rearrangement Generates Pattern Emergence as a Function of Temporal Morphogen Exposure
Timothy Fulton, Kay Speiss, Lewis Thomson, Yuxuan Wang, Bethan Clark, Seongwon Hwang, Brooks Paige, Berta Verd, Benjamin Steventon

In vivo imaging of calcium dynamics in zebrafish hepatocytes
Macarena Pozo-Morales, Inés Garteizgogeascoa, Camille Perazzolo, Sumeet Pal Singh

cdon and boc affect trunk neural crest cell migration through a non-cell autonomous reduction of hedgehog signaling in zebrafish slow-twitch muscle
Ezra Lencer, Rytis Prekeris, Kristin Artinger

Complement facilitates developmental microglial pruning of astrocyte and vascular networks
Gopalan Gnanaguru, Steven J. Tabor, Kentaro Yuda, Ryo Mukai, Jörg Köhl, Kip M. Connor

An essential function for autocrine Hedgehog signaling in epithelial proliferation and differentiation in the trachea
Wenguang Yin, Andreas Liontos, Janine Koepke, Maroua Ghoul, Luciana Mazzocchi, Xinyuan Liu, Chunyan Lu, Haoyu Wu, Athanasios Fysikopoulos, Alexandros Sountoulidis, Werner Seeger, Clemens Ruppert, Andreas Günther, Didier Y.R. Stainier, Christos Samakovlis

UMAP projection from Newton, et al.

Cell lineage specification during development of the anterior lateral plate mesoderm and forelimb field
Axel H Newton, Sarah M Williams, Andrew T Major, Craig A Smith

Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling
Douglas G. Brownfield, Alex Diaz de Arce, Elisa Ghelfi, Astrid Gillich, Tushar J. Desai, Mark A. Krasnow

Lysosomes are Required for Early Dorsal Signaling in the Xenopus Embryo
Nydia Tejeda-Muñoz, Edward M. De Robertis

High Hedgehog signaling is transduced by a multikinase-dependent switch controling the apico-basal distribution of the GPCR Smoothened
Marina Gonçalves-Antunes, Matthieu Sanial, Vincent Contremoulins, Sandra Carvalho, Anne Plessis, et Isabelle Bécam

pop-1/TCF, ref-2/ZIC and T-box factors regulate the development of anterior cells in the C. elegans embryo
Jonathan D. Rumley, Elicia A. Preston, Dylan Cook, Felicia L. Peng, Amanda L. Zacharias, Lucy Wu, Ilona Jileaeva, John Isaac Murray

| Morphogenesis & mechanics

Prenatal murine skeletogenesis partially recovers from absent skeletal muscle as development progresses
V. Sotiriou, S. Ahmed, N. C. Nowlan

Hemato-vascular specification requires arnt1 and arnt2 genes in zebrafish embryos
Hailey E. Edwards, Jaclyn P. Souder, Daniel A. Gorelick

Myofiber organisation from Mao, et al.

Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers
Qiyan Mao, Achyuth Acharya, Alejandra Rodríguez-delaRosa, Fabio Marchiano, Benoit Dehapiot, Ziad Al Tanoury, Jyoti Rao, Margarete Díaz-Cuadros, Arian Mansur, Erica Wagner, Claire Chardes, Vandana A. Gupta, Pierre-François Lenne, Bianca H. Habermann, Olivier Theodoly, Olivier Pourquie, Frank Schnorrer

Wnt11 family dependent morphogenesis during frog gastrulation is marked by the cleavage furrow protein anillin
Elizabeth S. Van Itallie, Christine M. Field, Timothy J. Mitchison, Marc W. Kirschnerm

Multifunctional role of GPCR signaling in epithelial tube formation
Vishakha Vishwakarma, Thao Phuong Le, SeYeon Chung

TrpA1 is a shear stress mechanosensing channel regulating intestinal homeostasis in Drosophila
Jiaxin Gong, Niraj K. Nirala, Jiazhang Chen, Fei Wang, Pengyu Gu, Qi Wen, Y. Tony Ip, Yang Xiang

Mechanics of human embryo compaction
Julie Firmin, Nicolas Ecker, Diane Rivet Danon, Virginie Barraud Lange, Hervé Turlier, Catherine Patrat, Jean-Léon Maître

SLC38A2 provides proline to fulfil unique synthetic demands arising during osteoblast differentiation and bone formation
Leyao Shen, Yilin Yu, Yunji Zhou, Shondra M. Pruett-Miller, Guo-Fang Zhang, Courtney M. Karner

Geometric control of Myosin-II orientation during axis elongation
M.F. Lefebvre, N.H. Claussen, N.P. Mitchell, H.J. Gustafson, S.J. Streichan

Growth orientations, rather than heterogeneous growth rates, dominate jaw joint morphogenesis in the larval zebrafish
Josepha Godivier, Elizabeth A. Lawrence, Mengdi Wang, Chrissy L. Hammond, Niamh C. Nowlan

Syndecan Regulates Cellular Morphogenesis in Cooperation with the Netrin Guidance Pathway and Rho-family GTPases
Raphaël Dima, Marianne Bah Tahé, Yann A. Chabi, Lise Rivollet, Anthony F. Arena, Alexandra M. Socovich, Daniel Shaye, Claire Y. Bénard

Hedgehog regulation of epithelial cell state and morphogenesis in the larynx
Janani Ramachandran, Weiqiang Zhou, Anna E. Bardenhagen, Talia Nasr, Aaron M. Zorn, Hongkai Ji, Steven A. Vokes

Cell cycle dynamics controls fluidity of the developing mouse neuroepithelium
Laura Bocanegra-Moreno, Amrita Singh, Edouard Hannezo, Marcin Zagorski, Anna Kicheva

Force-dependent remodeling of cytoplasmic ZO-1 condensates contributes to robust cell-cell adhesion
Noriyuki Kinoshita, Takamasa S. Yamamoto, Naoko Yasue, Chiyo Takagi, Toshihiko Fujimori, Naoto Ueno

Spheroids from Elosegui-Artola, et al.

Matrix viscoelasticity controls spatio-temporal tissue organization
Alberto Elosegui-Artola, Anupam Gupta, Alexander J. Najibi, Bo Ri Seo, Ryan Garry, Max Darnell, Wei Gu, Qiao Zhou, David A. Weitz, L. Mahadevan, David J. Mooney

A novel mechanism for left-right asymmetry establishment involving tissue remodeling and MyoID
Bénédicte M. Lefèvre, Marine Delvigne, Josué Vidal, Virginie Courtier-Orgogozo, Michael Lang

Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation
Jaclyn Camuglia, Soline Chanet, Adam C Martin

| Genes & genomes

High affinity enhancer-promoter interactions can bypass CTCF/cohesin-mediated insulation and contribute to phenotypic robustness
Shreeta Chakraborty, Nina Kopitchinski, Ariel Eraso, Parirokh Awasthi, Raj Chari, Pedro P Rocha

Oct1 recruits the histone lysine demethylase Utx to canalize lineage specification
Jelena Perovanovic, Yifan Wu, Zuolian Shen, Erik Hughes, Mahesh B. Chandrasekharan, Dean Tantin

Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-PRC1 axis
Dahai Wang, Mayuri Tanaka-Yano, Eleanor Meader, Melissa A. Kinney, Vivian Morris, Edroaldo Lummertz da Rocha, Nan Liu, Stuart H. Orkin, Trista E. North, George Q. Daley, R. Grant Rowe

Gata2, Nkx2-2 and Skor2 form a transcription factor network regulating development of a midbrain GABAergic neuron subtype with characteristics of REM sleep regulatory neurons
Anna Kirjavainen, Parul Singh, Laura Lahti, Patricia Seja, Zoltan Lelkes, Aki Makkonen, Sami Kilpinen, Yuichi Ono, Marjo Salminen, Teemu Aitta-Aho, Tarja Stenberg, Svetlana Molchanova, Kaia Achim, Juha Partanen

RETINOBLASTOMA RELATED (RBR) interaction with key factors of the RNA-directed DNA methylation (RdDM) pathway
León-Ruiz Jesús, Espinal-Centeno Annie, Blilou Ikram, Scheres Ben, Arteaga-Vázquez Mario, Cruz-Ramírez Alfredo

Distinct responses to rare codons in select Drosophila tissues
Scott R. Allen, Rebeccah K. Stewart, Michael Rogers, Ivan Jimenez Ruiz, Erez Cohen, Alain Laederach, Christopher M. Counter, Jessica K. Sawyer, Donald T. Fox

DNA methylation meta-analysis confirms the division of the genome into two functional groups
Lev Salnikov, Saveli Goldberg, Parvathy Sukumaran, Eugene Pinsky

Sociosexual behavior requires both activating and repressive roles of Tfap2e/AP-2ε in vomeronasal sensory neurons
Jennifer M. Lin, Tyler A. Mitchell, Megan Rothstein, Alison Pehl, Ed Zandro M. Taroc, Raghu R. Katreddi, Katherine E. Parra, Damian G. Zuloaga, Marcos Simoes-Costa, Paolo E. Forni

Identification and characterization of a dlx2b cis-regulatory element both sufficient and necessary for correct transcription during zebrafish tooth development
William R. Jackman, Yujin Moon, Drew R. Anderson, Audrey A. DeFusco, Vy M. Nguyen, Sarah Y. Liu, Elisabeth H. Carter, Hana E. Littleford, Elizabeth K. Richards, Andrea L. Jowdry

Heatmaps from Playfoot, et al.

Transposable elements contribute to the spatiotemporal microRNA landscape in human brain development
Christopher J. Playfoot, Shaoline Sheppard, Evarist Planet, Didier Trono

TEX13B is important for germ cell development and male fertility
Umesh Kumar, Digumarthi V S Sudhakar, Nithyapriya Kumar, Hanuman T Kale, Rajan Kumar Jha, Nalini J Gupta, B N Chakravarthy, Mamata Deenadayal, Aarti Deenadayal Tolani, Swasti Raychaudhuri, P Chandra Shekar, Kumarasamy Thangaraj

Genomic features underlie the co-option of SVA transposons as cis-regulatory elements in human pluripotent stem cells
Samantha M. Barnada, Andrew Isopi, Daniela Tejada-Martinez, Clément Goubert, Sruti Patoori, Luca Pagliaroli, Mason Tracewell, Marco Trizzino

Endogenous retroviruses co-opted as divergently transcribed regulatory elements shape the regulatory landscape of embryonic stem cells
Stylianos Bakoulis, Robert Krautz, Nicolas Alcaraz, Marco Salvatore, Robin Andersson

Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in Drosophila melanogaster
Aaron T. Crain, Stephen Klusza, Robin L. Armstrong, Priscila Santa Rosa, Brenda R. S. Temple, Brian D. Strahl, Daniel J. McKay, A. Gregory Matera, Robert J. Duronio

DiSCs – Domains involving SETDB1 and Cohesin are critical regulators of genome topology and stem cell fate
Tushar Warrier, Chadi El Farran, Yingying Zeng, Benedict Shao Quan Ho, Don Loi Xu, Qiuye Bao, Zi Hao Zheng, Xuezhi Bi, Kelly Yu Sing Tan, Huck Hui Ng, Derrick Sek Tong Ong, Justin Jang Hann Chu, Amartya Sanyal, Melissa Jane Fullwood, James Collins, Hu Li, Jian Xu, Yuin-Han Loh

| Stem cells, regeneration & disease modelling

Distinct roles of core autophagy-related genes (ATGs) in zebrafish definitive hematopoiesis
Xiang-Ke Chen, Zhen-Ni Yi, Jack Jark-Yin Lau, Alvin Chun-Hang Ma

Effects of α-crystallin gene knockout on zebrafish lens development
Mason Posner, Kelly L. Murray, Brandon Andrew, Stuart Brdicka, Alexis Butterbaugh-Roberts, Kirstan Franklin, Adil Hussen, Taylor Kaye, Emmaline Kepp, Mathew S. McDonald, Tyler Snodgrass, Keith Zientek, Larry David

Hbxip (Lamtor5) is essential for embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1
Yan Qin, Peiling Ni, Qingye Zhang, Xiao Wang, Xiaoling Du, Zixi Yin, Lingling Wang, Lihong Ye, Lingyi Chen

hPSC-Derived Enteric Ganglioids Model Human ENS Development and Function
Homa Majd, Ryan M Samuel, Jonathan T Ramirez, Ali Kalantari, Kevin Barber, Zaniar Ghazizadeh, Angeline K Chemel, Andrius Cesiulis, Mikayla N Richter, Subhamoy Das, Matthew G Keefe, Jeffrey Wang, Rahul K Shiv, Conor J McCann, Samyukta Bhat, Matvei Khoroshkin, Johnny Yu, Tomasz J Nowakowski, Hani Goodarzi, Nikhil Thapar, Julia A Kaltschmidt, Faranak Fattahi

Vascular buds of Botryllus schlosseri from Ricci, et al.

The onset of whole-body regeneration in Botryllus schlosseri: morphological and molecular characterization
Lorenzo Ricci, Bastien Salmon, Caroline Olivier, Rita Andreoni-Pham, Ankita Chaurasia, Alexandre Alie, Stefano Tiozzo

Macrophages break interneuromast cell quiescence by intervening the inhibition of Schwann cells in zebrafish lateral line
Meng-Ju Lin, Chia-Ming Lee, Wei-Lin Hsu, Bi-Chang Chen, Shyh-Jye Lee

Spatially unique Shh-Fgf8 distribution in regenerating limb guarantees consistent limb morphogenesis in different limb sizes and contributes to axolotl specific digit patterning
Saya Furukawa, Sakiya Yamamoto, Rena Kashimoto, Yoshihiro Morishita, Akira Satoh

Generation of rat lungs by blastocyst complementation in Fgfr2b-deficient mouse model
Shunsuke Yuri, Yuki Murase, Ayako Isotani

SOX17 Is Not Required for the Derivation and Maintenance of Mouse Extraembryonic Endoderm Stem Cell Lines
Xudong Dong, Ailing Ding, Jiangwei Lin

Single-cell Transcriptomic Profiling Unveils Cardiac Cell-type Specific Response to Maternal Hyperglycemia Underlying the Risk of Congenital Heart Defects
Sathiyanarayanan Manivannan, Corrin Mansfield, Xinmin Zhang, Karthik. M. Kodigepalli, Uddalak Majumdar, Vidu Garg, Madhumita Basu

Hypertrophic Chondrocytes Serve as a Reservoir for Marrow Associated Skeletal Stem and Progenitor Cells, Osteoblasts, and Adipocytes During Skeletal Development
Jason T. Long, Abigail Leinroth, Yihan Liao, Yinshi Ren, Anthony J. Mirando, Tuyet Nguyen, Wendi Guo, Deepika Sharma, Douglas Rouse, Colleen Wu, Kathryn Song Eng Cheah, Courtney M. Karner, Matthew J. Hilton

Differential Requirement of DICER1 Activity during Development of Mitral and Tricuspid Valves
Shun Yan, Yin Peng, Jin Lu, Saima Shakil, Yang Shi, David K. Crossman, Walter H Johnson Jr., Shanrun Liu, Joy Lincoln, Qin Wang, Kai Jiao

Amniotic fluid stem cell extracellular vesicles promote fetal lung branching and cell differentiation in experimental congenital diaphragmatic hernia
Kasra Khalaj, Rebeca Lopes Figueira, Lina Antounians, Sree Gandhi, Matthew Wales, Louise Montalva, George Biouss, Augusto Zani

Autophagy is impaired in fetal hypoplastic lungs and rescued by administration of amniotic fluid stem cell extracellular vesicles
Kasra Khalaj, Lina Antounians, Rebeca Lopes Figueira, Martin Post, Augusto Zani

Origin of congenital coronary arterio-ventricular fistulae from anomalous epicardial and myocardial development
P Palmquist-Gomes, A Ruiz-Villalba, JA Guadix, JP Romero, B Bessiéres, D MacGrogan, L Conejo, A Ortiz, B Picazo, L Houyel, D Gómez-Cabrero, SM Meilhac, JL de la Pompa, JM Pérez-Pomares

Airway epithelium in E14.5 mouse lungs from Eenjes, et al.

Distinct roles for SOX2 and SOX21 in differentiation, distribution and maturation of pulmonary neuroendocrine cells
Evelien Eenjes, Anne Boerema-de Munck, Marjon Buscop-van Kempen, Dick Tibboel, Robbert J. Rottier

The developmental origin and the specification of the adrenal cortex in humans and cynomolgus monkeys
Keren Cheng, Yasunari Seita, Taku Moriwaki, Kiwamu Noshiro, Yuka Sakata, Young Sun Hwang, Toshihiko Torigoe, Mitinori Saitou, Hideaki Tsuchiya, Chizuru Iwatani, Masayoshi Hosaka, Toshihiro Ohkouchi, Hidemichi Watari, Takeshi Umazume, Kotaro Sasaki

Decoding the activated stem cell phenotype of the vividly maturing neonatal pituitary
Emma Laporte, Florian Hermans, Silke De Vriendt, Annelies Vennekens, Diether Lambrechts, Charlotte Nys, Benoit Cox, Hugo Vankelecom

Coupled myovascular expansion directs cardiac growth and regeneration
Paige DeBenedittis, Anish Karpurapu, Albert Henry, Michael C. Thomas, Timothy J. McCord, Kyla Brezitski, Anil Prasad, Yoshihiko Kobayashi, Svati H. Shah, Christopher D. Kontos, Purushothama Rao Tata, R. Thomas Lumbers, Ravi Karra

Alteration of myocardial structure and function in RAF1-associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs
Saeideh Nakhaei-Rad, Farhad Bazgir, Julia Dahlmann, Alexandra Viktoria Busley, Marcel Buchholzer, Fereshteh Haghighi, Anne Schänzer, Andreas Hahn, Sebastian Kötter, Denny Schanze, Ruchika Anand, Florian Funk, Andrea Borchardt, Annette Vera Kronenbitter, Jürgen Scheller, Roland P. Piekorz, Andreas S. Reichert, Marianne Volleth, Matthew J. Wolf, Ion Cristian Cirstea, Bruce D. Gelb, Marco Tartaglia, Joachim Schmitt, Martina Krüger, Ingo Kutschka, Lukas Cyganek, Martin Zenker, George Kensah, Mohammad R. Ahmadian

Central role of Prominin-1 in lipid rafts during liver regeneration
Myeong-Suk Bahn, Dong-Min Yu, Myoungwoo Lee, Sung-Je Jo, Ji-Won Lee, Hyun Lee, Arum Kim, Jeong-Ho Hong, Jun Seok Kim, Seung-Hoi Koo, Jae-Seon Lee, Young-Gyu Ko

Plasticity of body axis polarity in Hydra regeneration under constraints
Anton Livshits, Liora Garion, Yonit Maroudas-Sacks, Lital Shani-Zerbib, Kinneret Keren, Erez Braun

Dual specificity phosphatase 7 drives the formation of cardiac mesoderm in mouse embryonic stem cells
Stanislava Sladeček, Katarzyna Anna Radaszkiewicz, Martina Bőhmová, Tomáš Gybeľ, Tomasz Witold Radaszkiewicz, Jiří Pacherník

TRF2 rescues pathogenic phenotypes in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs
Asuka Eguchi, Sofía I. Torres-Bigio, Kassie Koleckar, Foster Birnbaum, Helen M. Blau

Limb Specific Failure of Proliferation and Translation in the Mesenchyme Leads to Skeletal Defects in Diamond Blackfan Anemia
Jimmy Hom, Theodoros Karnavas, Emily Hartman, Julien Papoin, Yuefeng Tang, Brian M. Dulmovits, Mushran Khan, Hiren Patel, Jedediah Bondy, Morris Edelman, Renaud Touraine, Geneviève Chanoz-Poulard, Gregory Ottenberg, Robert Maynard, Douglas J. Adams, Raymond F. Robledo, Daniel A Grande, Philippe Marambaud, Betsy J Barnes, Sébastien Durand, Anupama Narla, Steven Ellis, Leonard I. Zon, Luanne L. Peters, Lydie Da Costa, Jeffrey M. Lipton, Cheryl L. Ackert-Bicknell, Lionel Blanc

Myeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence
Dorsa Toghani, Sharon Zeng, Elmir Mahammadov, Edie I. Crosse, Negar Seyedhassantehrani, Christian Burns, David Gravano, Stefan Radtke, Hans-Peter Kiem, Sonia Rodriguez, Nadia Carlesso, Amogh Pradeep, Nicola K. Wilson, Sarah J. Kinston, Berthold Göttgens, Claus Nerlov, Eric Pietras, Marion Mesnieres, Christa Maes, Atsushi Kumanogoh, Thomas Worzfeld, Peter Kharchenko, David T. Scadden, Antonio Scialdone, Joel A Spencer, Lev Silberstein

Lung injury induces alveolar type 2 cell hypertrophy and polyploidy with implications for repair and regeneration
Anthea Weng, Mariana Maciel-Herrerias, Satoshi Watanabe, Lynn Welch, Annette S. Flozak, Rogan Grant, Raul Piseaux Aillon, Laura Dada, Seung Hye Han, Monique Hinchcliff, Alexander Misharin, GR Scott Budinger, Cara J. Gottardi

Mouse intestinal crypts from Niec, et al.

A lymphatic-stem cell interactome regulates intestinal stem cell activity
Rachel E. Niec, Tinyi Chu, Shiri Gur-Cohen, Marina Schernthanner, Lynette Hidalgo, Hilda Amalia Pasolli, Raghu P. Kataru, Babak J. Mehrara, Dana Pe’er, Elaine Fuchs

Lymphatics constitute a novel component of the intestinal stem cell niche
Norihiro Goto, Shinya Imada, Vikram Deshpande, Ömer H. Yilmaz

| Plant development

Integrated cyto-physiological and proteomic analyses reveal new insight into CMS mechanism in a novel upland cotton CMS line LD6A
Zheng Jie, Aziz Khan, Zhou Bujin, Zhou Qiong, Najeeb Ullah, Kong Xiangjun, Liu Yiding, Liu Fang, Zhou Ruiyang

Microscopic and ultramicroscopic anatomical characteristics of root nodules in Podocarpus macrophyllus during development
Li-Qiong Zhu, Hui-Xin Chen, Li-Jun Zhao, Wei-Xin Jiang

Cell- and non-cell-autonomous ARF3 coordinates meristem proliferation and organ patterning in Arabidopsis
Ke Zhang, Hao Zhang, Yanyun Pan, Lin Guo, Shijun Tian, Jiarong Wei, Yunze Fu, Cong Wang, Ping Qu, Liantao Liu, Yongjiang Zhang, Hongchun Sun, Zhiying Bai, Jingao Dong, Cundong Li, Xigang Liu

Persistence of parental age effect on somatic mutation rates across generations in Arabidopsis
Shashi Bhushan, Amit Kumar Singh, Yogendra Thakur, Ramamurthy Baskar

GhCO and GhCRY1 accelerate floral meristem initiation in response to increased blue light to shorten cotton breeding
Xiao Li, Yuanlong Wu, Zhenping Liu, Zhonghua Li, Huabin Chi, Pengcheng Wang, Feilin Yan, Yang Yang, Yuan Qin, Xuehan Tian, Hengling Wei, Aimin Wu, Hantao Wang, Xianlong Zhang, Shuxun Yu

The m6A writer FIONA1 methylates the 3’UTR of FLC and controls flowering in Arabidopsis
Bin Sun, Kaushal Kumar Bhati, Ashleigh Edwards, Louise Petri, Valdeko Kruusvee, Anko Blaakmeer, Ulla Dolde, Vandasue Rodrigues, Daniel Straub, Stephan Wenkel

ARF small GTPases in the developmental function mediated by ARF regulators GNOM and VAN3
Maciek Adamowski, Ivana Matijević, Jiří Friml

Actin isovariant ACT7 controls root meristem development in Arabidopsis through modulating auxin and ethylene responses
Takahiro Numata, Kenji Sugita, Arifa Ahamed Rahman, Abidur Rahman

Developmental patterning function of GNOM ARF-GEF mediated from the plasma membrane
Maciek Adamowski, Ivana Matijević, Jiří Friml

Physcomitrium gametophores from Thelander, et al.

Apical and basal auxin sources pattern shoot branching in a moss
Mattias Thelander, Katarina Landberg, Arthur Muller, Gladys Cloarec, Nik Cunniffe, Stéphanie Huguet, Ludivine Soubigou-Taconnat, Véronique Brunaud, Yoan Coudert

Single-cell transcriptome reveals the redifferentiation trajectories of the early stage of de novo shoot regeneration in Arabidopsis thaliana
Guangyu Liu, Jie Li, Ji-Ming Li, Zhiyong Chen, Peisi Yuan, Ruiying Chen, Ruilian Yin, Zhiting Liao, Xinyue Li, Ying Gu, Hai-Xi Sun, Keke Xia

Pectin cell wall remodeling through PLL12 and callose deposition through polar CALS7 are necessary for long-distance phloem transport
Lothar Kalmbach, Matthieu Bourdon, Jung-ok Heo, Sofia Otero, Bernhard Blob, Ykä Helariutta

Knockout of OsSWEET15 impaired rice embryo formation and seed-setting
Zhenjia Tang, Jing Yang, Shuhui Bao, Zhi Hu, Huihuang Xia, Lai Ma, Qingsong Zheng, Fang Yang, Dechun Zhang, Tai Wang, Shubin Sun, Yibing Hu

MISF2 Encodes an Essential Mitochondrial Splicing Co-factor Required for nad2 mRNA Processing and Embryo Development in Arabidopsis thaliana
Tan-Trung Nguyen , Corinne Best , Sofia Shevtsov , Michal Zmudjak , Martine Quadrado , Ron Mizrahi , Hagit Zer , Hakim Mireau , Oren Ostersetzer-Biran

| Evo-devo

Ontogenetic Color Switching in Lizards as a by-Product of Guanine Cell Development
Gan Zhang, Venkata Jayasurya Yallapragada, Michal Shemesh, Avital Wagner, Alexander Upcher, Iddo Pinkas, Harry L.O. McClelland, Dror Hawlena, Benjamin A. Palmer

Assessing Myf5 and Lbx1 contribution to carapace development by reproducing their turtle-specific signatures in mouse embryos
Triin Tekko, Ana Nóvoa, Moisés Mallo

An ancient role for the Hippo pathway in axis formation and morphogenesis
Maria Brooun, Willi Salvenmoser, Catherine Dana, Marius Sudol, Robert Steele, Bert Hobmayer, Helen McNeill

Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organization
Márton Demeter, Imre Derényi, Gergely J. Szöllősi

Cell Biology

Cardiomyocyte differentiation from iPS cells is delayed following knockout of Bcl-2
Tim Vervliet, Robin Duelen, H. Llewelyn Roderick, Maurilio Sampaolesi

Conserved meiotic mechanisms in the cnidarian Clytia hemisphaerica revealed by Spo11 knockout
Catriona Munro, Hugo Cadis, Evelyn Houliston, Jean-René Huynh

Acetyl-CoA mediated autoacetylation of fatty acid synthase in de novo lipogenesis
Ting Miao, Jinoh Kim, Ping Kang, Hua Bai

unc-37/Groucho and lsy-22/AES repress Wnt target genes in C. elegans asymmetric cell divisions
Kimberly N. Bekas, Bryan T. Phillips

Cross sections of mouse sperm tails from Zhang, et al.

Ccdc38 is required for sperm flagellum biogenesis and male fertility in mouse
Ruidan Zhang, Bingbing Wu, Chao Liu, Xiuge Wang, Liying Wang, Sai Xiao, Yinghong Chen, Huafang Wei, Fei Gao, Li Yuan, Wei Li

Germline-soma Supply Mitochondria for mtDNA Inheritance in Mouse Oogenesis
Hongying Sha, Zhao Ye, Zhen Ye, Sanbao Shi, Jianxin Pan, Xi Dong, Yao Zhao

Progenitor cell integration into a barrier epithelium during adult organ turnover
Paola Moreno-Roman, Yu-Han Su, Anthony Galenza, Lehi Acosta-Alvarez, Alain Debec, Antoine Guichet, Jon-Michael Knapp, Caroline Kizilyaprak, Bruno M. Humbel, Irina Kolotuev, Lucy Erin O’Brien

Rab35 Governs Apicobasal Polarity Through Regulation of Actin Dynamics During Sprouting Angiogenesis
Caitlin R. Francis, Hayle Kincross, Erich J. Kushner

Fat2 polarizes the WAVE complex in trans to align cell protrusions for collective migration
Audrey M. Williams, Seth Donoughe, Edwin Munro, Sally Horne-Badovinac

A key role for p60-Katanin in axon navigation is conditioned by the tubulin polyglutamylase TTLL6
Daniel Ten Martin, Nicolas Jardin, François Giudicelli, Laïla Gasmi, Juliette Vougny, Cécile Haumaître, Xavier Nicol, Carsten Janke, Coralie Fassier, Jamilé Hazan
doi: https://doi.org/10.1101/2022.01.20.477127

PP1 phosphatases control PAR-2 localization and polarity establishment in C. elegans embryos
Ida Calvi, Françoise Schwager, Monica Gotta

The biosynthetic-secretory pathway, supplemented by recycling routes, specifies epithelial membrane polarity
Nan Zhang, Hongjie Zhang, Liakot A. Khan, Gholamali Jafari, Yong Eun, Edward Membreno, Verena Gobel

ZYG-9ch-TOG promotes the stability of acentrosomal poles via regulation of spindle microtubules in C. elegans oocyte meiosis
Timothy J. Mullen, Gabriel Cavin-Meza, Ian D. Wolff, Emily R. Czajkowski, Nikita S. Divekar, Justin D. Finkle, Sarah M. Wignall

A flexible network of lipid droplet associated proteins support embryonic integrity of C. elegans
Zhe Cao, Chun Wing Fung, Ho Yi Mak

Modelling

Cell Centred Finite Element Model for Intestinal Organoids Shape Analysis: From tissue architecture to mechanics
J. Laussu, D. Michel, S. Segonds, S. Marguet, F. Barreau, D. Hamel, E. Mas, A. Ferrand, F. Bugarin

The grapevine leaves that are (or were) not: constraints on leaf development and choosing to see what seemingly is not
Daniel H. Chitwood, Joey Mullins

Modelling tissue elongation from Koyama, et al.

Differential cellular stiffness contributes to tissue elongation on an expanding surface
Hiroshi Koyama, Makoto Suzuki, Naoko Yasue, Hiroshi Sasaki, Naoto Ueno, Toshihiko Fujimori

Contact-mediated signaling enables disorder-driven transitions in cellular assemblies
Chandrashekar Kuyyamudi, Shakti N. Menon, Sitabhra Sinha

Spontaneous mechanical and energetic state transitions during Caenorhabditis elegans gastrulation
Jiao Miao, Guoye Guan, Chao Tang

Oscillations and Bifurcation Structure of Reaction-Diffusion Model for Cell Polarity Formation
Masataka Kuwamura, Hirofumi Izuhara, Shin-ichiro Ei

Reviews

Retina organoids: Window into the biophysics of neuronal systems
Katja A. Salbaum, Elijah R. Shelton, Friedhelm Serwane

The two body problem: proprioception and motor control across the metamorphic divide
Sweta Agrawal, John C Tuthill

Tardigrades and Their Emergence as Model Organisms
Bob Goldstein

Tools & Resources

oca2 targeting using CRISPR/Cas9 in the Malawi cichlid Astatotilapia calliptera
Bethan Clark, Joel Elkin, Aleksandra Marconi, George F. Turner, Alan M. Smith, Domino Joyce, Eric A. Miska, Scott A. Juntti, M. Emília Santos

mBeRFP, a versatile fluorescent tool to enhance multichannel live imaging and its applications
Emmanuel Martin, Magali Suzanne

Sex-specific association between urinary kisspeptin and pubertal development
Rafaella Sales de Freitas, Thiago Fonseca Alves França, Sabine Pompeia

The generation of a Nutm1 knock-in reporter mouse line for imaging post-meiotic spermatogenesis
Maxwell Hakun, Janet Rossant, Bin Gu

Vascularised brain organoids from Sun, et al.

Generation of Vascularized Brain Organoids to Study Neurovascular Interactions
Xin-Yao Sun, Xiang-Chun Ju, Yang Li, Peng-Ming Zeng, Jian Wu, Li-Bing Shen, Yue-Jun Chen, Zhen-Ge Luo

A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates
Peng He, Kyungtae Lim, Dawei Sun, Jan Patrick Pett, Quitz Jeng, Krzysztof Polanski, Ziqi Dong, Liam Bolt, Laura Richardson, Lira Mamanova, Monika Dabrowska, Anna Wilbrey-Clark, Elo Madissoon, Zewen Kelvin Tuong, Emma Dann, Chenqu Suo, Isaac Goh Kai’En, Xiaoling He, Roger Barker, Sarah A Teichmann, John C. Marioni, Kerstin B Meyer, Emma L Rawlins

Developmental origins of cell heterogeneity in the human lung
Alexandros Sountoulidis, Sergio Marco Salas, Emelie Braun, Christophe Avenel, Joseph Bergenstråhle, Marco Vicari, Paulo Czarnewski, Jonas Theelke, Andreas Liontos, Xesus Abalo, Žaneta Andrusivová, Michaela Asp, Xiaofei Li, Lijuan Hu, Sanem Sariyar, Anna Martinez Casals, Burcu Ayoglu, Alexandra Firsova, Jakob Michaëlsson, Emma Lundberg, Carolina Wählby, Erik Sundström, Sten Linnarsson, Joakim Lundeberg, Mats Nilsson, Christos Samakovlis

EZ Clear for simple, rapid, and robust mouse whole organ clearing
Chih-Wei Hsu, Juan Cerda III, Jason M. Kirk, Williamson D. Turner, Tara L. Rasmussen, Carlos P. Flores Suarez, Mary E. Dickinson, Joshua D. Wythe

FRaeppli, a multispectral imaging toolbox for cell tracing and dense tissue analysis in zebrafish
Sara Caviglia, Iris A. Unterweger, Akvilė Gasiūnaitė, Alexandre E. Vanoosthuyse, Francesco Cutrale, Le A. Trinh, Scott E. Fraser, Stephan C. F. Neuhauss, Elke A. Ober

Mechanosensitive Osteogenesis on Native Cellulose Scaffolds for Bone Tissue Engineering
Maxime Leblanc Latour, Andrew E. Pelling

Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons
Lewis Macdonald, Gillian Taylor, Jennifer Brisbane, Ersi Christodoulou, Lucy Scott, Alex Von Kriegsheim, Janet Rossant, Bin Gu, Andrew Wood

Tobacco seedings from Li, et al

Highly efficient multiplex genome editing in dicots using improved CRISPR/Cas systems
Bingjie Li, Yun shang, Lixianqiu Wang, Jing Lv, Fengjiao Wang, Jiangtao Chao, Jingjing Mao, Anming Ding, Xinru Wu, Mengmeng Cui, Yuhe Sun, Changbo Dai

Light-driven biological actuators to probe the rheology of 3D microtissues
Adrien Méry, Artur Ruppel, Jean Révilloud, Martial Balland, Giovanni Cappello, Thomas Boudou

Research practice & education

Becoming metrics literate: An analysis of brief videos that teach about the h-index
Lauren A. Maggio, Alyssa Jeffrey, Stefanie Haustein, Anita Samuel

Integrating Math Modeling, Coding, and Biology in a CURE Lab
Renee Dale, Stewart Craig

Re-use of labware reduces CO2 equivalent footprint and running costs in laboratories
Martin Farley, Benoit P. Nicolet

A remote lecture series roadmap to equity, diversity, and inclusion in STEM
Evan A. Boyle, Gabriela Goldberg, Jonathan C. Schmok, Jillybeth Burgado, Fabiana Izidro Layng, Hannah A. Grunwald, Kylie M. Balotin, Michael S. Cuoco, Keng-Chi Chang, Gertrude Ecklu-Mensah, Aleena K. S. Arakaki, Noorsher Ahmed, Ximena Garcia Arceo, Pratibha Jagannatha, Jonathan Pekar, Mallika Iyer, DASL Alliance, Gene W. Yeo

The role of collegiality in academic review, promotion, and tenure
Diane Dawson, Esteban Morales, Erin C. McKiernan, Lesley A. Schimanski, Meredith T. Niles, Juan Pablo Alperin

Virtually the same? Evaluating the effectiveness of remote undergraduate research experiences
Riley A. Hess, Olivia A. Erickson, Rebecca B. Cole, Jared M. Isaacs, Silvia Alvarez-Clare, Jonathan Arnold, Allison Augustus-Wallace, Joseph C. Ayoob, Alan Berkowitz, Janet Branchaw, Kevin R. Burgio, Charles H. Cannon, Ruben Michael Ceballos, C. Sarah Cohen, Hilary Coller, Jane Disney, Van A. Doze, Margaret J. Eggers, Edwin L. Ferguson, Jeffrey J. Gray, Jean T. Greenberg, Alexander Hoffmann, Danielle Jensen-Ryan, Robert M. Kao, Alex C. Keene, Johanna E. Kowalko, Steven A. Lopez, Camille Mathis, Mona Minkara, Courtney J. Murren, Mary Jo Ondrechen, Patricia Ordoñez, Anne Osano, Elizabeth Padilla-Crespo, Soubantika Palchoudhury, Hong Qin, Juan Ramírez-Lugo, Jennifer Reithel, Colin A. Shaw, Amber Smith, Rosemary J. Smith, Fern Tsien, Erin L. Dolan

Correction of the scientific production: publisher performance evaluation using a dataset of 4844 PubMed retractions
Catalin Toma, Liliana Padureanu, Bogdan Toma

High School Science Fair: Ethnicity Trends in Student Participation and Experience
Frederick Grinnell, Simon Dalley, Joan Reisch




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