Postdoc position (Yale) – Gene Regulation/Chromatin Biophysics

Postdoc Position (Meyer lab) – Systems Biology Institute and Molecular, Cellular, and Developmental Biology Department, Yale University

The Meyer lab (meyerlab.yale.edu) is part of the Department of Molecular, Cellular and Developmental Biology, and the Systems Biology Institute at Yale University. We are seeking passionate, creative, and open-minded postdocs to join us to work on understanding principles of gene regulation and embryonic development. As the Meyer Lab is newly established, this is a unique opportunity to contribute to building a dynamic lab environment.

We seek to understand the molecular logic of cellular decision making in the context of embryonic development. We are interested in gene regulation and the role of signaling dynamics, and chromatin mechanics/biophysics in sensing, processing, and memorizing information. To study this, we synthetically control signaling nodes and combine this approach with imaging-based readouts to record information flow at molecular resolution. To this end, we use advanced imaging approaches (light-sheet single-molecule imaging), optogenetics, synthetic biology tools, and CRISPR/Cas9-gene editing of mouse embryonic stem cells.

Representative publications:

Meyer K, Yserentant K, Cheloor-Kovilakam R, Ruff KM, Chung C, Shu X, Huang B, Weiner OD. (2024) YAP charge patterning mediates signal integration through transcriptional co-condensates. bioRxiv, doi: 10.1101/2024.08.10.607443.

Meyer K, Lammers NC, Bugaj LJ, Garcia, HG, Weiner OD. (2023) Optogenetic control of YAP reveals a dynamic communication code for stem cell fate and proliferation. Nature Communications, 14(1): 6929, PMCID: PMC10616176

Qualifications: Applicants should hold a PhD in Biological Sciences or a related field (e.g. Bioengineering, Biophysics).

The position is available immediately and available until filled.

Application Instructions: Interested applicants should email a cover letter describing their research experience and future goals, a CV, and the names and contact information of three references to: kirstin.meyer@yale.edu.