The Developmental Biology Group (Prof. I. Lohmann) at the Centre for Organismal Studies (COS) in Heidelberg, Germany is looking for a
to study the role of HOX transcription factors in controlling cellular plasticity and cell fate maintenance.
You will join the Lohmann lab (http://ilohmann-lab.org), which is located at the Centre for Organismal Studies (COS) at the University of Heidelberg in Germany, and studies the role of HOX transcription factors in defining cell type identities using Drosophilaas a model.
Cell fates are controlled by networks of transcription factors (TFs) that activate transcriptional programs realizing the distinct properties of cells of a given cell types.However, how TFs control different cell fates is still un unsolved question. HOX TFs represent an excellent model to address this fundamental problem, since they are broadly expressed yet perform highly specific functions within different cell types. We have previously shown that Hox TFs stabilize cell fate choices by suppressing the multipotency encoded in the genome via the interaction with the Polycomb complex. We now seek for enthusiastic new colleagues to analyse our hypothesis that elimination of the Hox code, which is maintained throughout the lifetime of an organism, results in “memory-less” naïve cells that are easy to reprogram.
The Heidelberg Molecular Life Science Community offers a vibrant molecular research community, as well as state-of-the-art core facilities.
Successful candidates should have experience in genomic approaches like RNA-seq, ChIP-seq, ATAC-seq, analysis of genomic data, confocal microscopy, advanced immunohistochemistry and possibly in Drosophila genetics and molecular biology. The ability to quickly integrate into an interdisciplinary team and work independently within an academic research environment is essential. The position is immediately available, the salary is according to TV-L regulations. Disabled persons with comparable skills will be preferentially considered.
Applications should be sent to:
Prof. Dr. Ingrid Lohmann
Centre for Organismal Studies (COS) Heidelberg
Im Neuenheimer Feld 267
D- 69120 Heidelberg, Germany