A postdoctoral position is available for an initial period of 2 years at the “Stem Cell and Brain Research Institute” (www.sbri.fr) in the lab of Dr Olivier Raineteau.
The project follows two recent studies from the team demonstrating transcriptional heterogeneity of postnatal neural progenitors (Donega et al., Cell Report, 2018), and their amenability to pharmacological manipulation (Azim et al., Plos Biology, 2017). It aims at using transcriptomic, as well as fate-mapping approaches to study neural progenitors (endogenous or induced) and their capacity to produce define cell types, including distinct neuronal subtypes. The project involves close collaborations with the laboratories of Denis Jabaudon (CMU, Geneva) and Christophe Heinrich (within the SBRI institute).
We are seeking highly motivated candidates with a PhD in biological sciences with a strong interest in developmental neurosciences. The candidate will have an expertise in fate mapping approaches. Previous experience with bio-informatics analysis (e.g. single cell RNA-Sequencing analysis, R Studio, Seurat) is also required.
Environment: The team has a long-standing expertise in the field of postnatal forebrain neurogenesis and CNS repair. It is part of the Stem cell and Brain Research Institute (SBRI), and exciting international multidisciplinary research centre. The working languages are French and English.
Closing date: 15/06/2020
Employment start date: 01/09/2020
Institution: Inserm U1208
Department: Stem cell and Brain Research Institute
Dr Olivier Raineteau
Stem Cell and Brain Research Institute
18 avenue Doyen Lépine
FR-69675 Bron cedex
Applicants should send their CV, a motivation letter, 3 references (name, e-mail, address, phone no.) before the 15th of June to: email@example.com
Selected publications :
- Donega V, Marcy G, Lo Giudice Q, Zweifel S, Angonin D, Fiorelli R, Abrous DN, Rival Gervier S, Koehl M, Jabaudon D, Raineteau O (2018) Transcriptional Dysregulation in Postnatal Glutamatergic Progenitors Contributes to Closure of the Cortical Neurogenic Period. Cell Rep. 22(10):2567-2574
- Azim K, Angonin D, Marcy G, Pieropan F, Rivera A, Donega V, Cantu C, Williams G, Berninger B, Butt AM, Raineteau O (2017). Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity. Plos Biology; 15(3):e2000698.
- Azim K, Hurtado-Chong A, Fischer B, Kumar N, Zweifel S, Taylor V, Raineteau O (2015) Transcriptional Hallmarks of Heterogeneous Neural Stem Cell Niches of the Subventricular Zone. Stem Cells. 33(7):2232-42