Postdoctoral Research Associate in Developmental Biology – University of Manchester

We seek a candidate for a Wellcome Trust-funded Research Associate position working on an interdisciplinary project investigating the roles of subcellular targeting of mRNAs in the spatial control of local cell shape remodelling and tissue morphogenesis. This project is based in the laboratory of Dr Shane Herbert (University of Manchester, UK) and builds upon our recent work revealing that the precise subcellular targeting of mRNAs and resulting local protein translation acts as a molecular compass that drives local cell shape changes, orients motile cell polarity and spatially directs tissue movement during blood vessel formation in vivo (Costa. G., et. al. 2019. bioRxiv). In particular, this project will exploit novel optogenetic tools to achieve light-induced dynamic modulation of mRNA subcellular localisation, both in vitro and in vivo during zebrafish embryonic development, with an aim to define the fundamental mechanisms and function of mRNA targeting in the control of broad aspects of in vivo tissue behaviour.

The successful applicant will already hold (or have nearly completed) a PhD in a relevant discipline and have experience of either live cell imaging, optogenetics, CRISPR gene-editing and/or the zebrafish model system.

The position is available from 1st April 2020 and is tenable for up to 60 months full time (Later start dates are negotiable). For more details of the laboratory, please see www.herbertlab.com.

Informal enquiries can be made to Dr. S. Herbert.
Tel: 0161 275 1140
Email shane.herbert@manchester.ac.uk

Application forms and further particulars can be obtained at http://www.manchester.ac.uk/aboutus/jobs/

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