A post is available on a BBSRC funded project to examine the functional role of Nanog and downstream target genes during primordial germ cell (PGC) development. We have shown that Nanog-null PGCs do not develop fully and this post will determine the residues within Nanog that mediate function, test the possibility that the Nanog target gene Esrrb can rescue Nanog-null PGC function and explore the PGC-specific role of other Nanog targets. Post holder will have (or shortly obtain) a Ph.D. in Development or Stem Cell Biology and a keen interest in understanding how cell identity is controlled. You should be familiar with gene targeting, techniques for high throughput RNA analysis and be able to perform immunofluorescence and QPCR. An ability to culture EpiSCs, potentially differentiating cells to PGC-like cells is desirable, as is the ability to isolate in vivo PGCs. Post is full-time and fixed term for up to 36 months.
£30,424 – £36,298 pa
Vacancy ref: 022449
Deadline for applications is Monday 16th December 2013
A full job description and details of how to apply can be found on The University of Edinburgh website at: https://www.vacancies.ed.ac.uk