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Research Associate (Alcolea Lab)

Posted by , on 2 November 2016

Closing Date: 15 March 2021

Department/Location: Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute, University of Cambridge

Salary: £29,301-£38,183

Reference: PS10618

Closing date: 01 December 2016

Fixed-term: The funds for this post are available for 2 years in the first instance.

The Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments.

We are looking for a self-motivated, reliable and well-trained post-doctoral researcher to join the research team of Dr. Maria Alcolea. Her team will investigate epithelial stem cell plasticity upon tissue regeneration and early cancer using oesophageal models.

In order to protect tissue integrity, epithelial cells have a significant ability to change and adapt their behaviour in response to changing tissue perturbations. Investigating the cellular and molecular mechanisms governing this dynamic cell behaviour, and the potential implications for early cancer development will represent the main focus of this study.

We will utilise a combination of in vivo lineage tracing techniques using genetic mouse models, ex vivo 3D organ cultures, and single cell transcriptional network analysis to define changes in epithelial cell behaviour during tissue regeneration and cancer.



We are looking for candidates who hold a PhD degree or will obtain a PhD degree within a year in the field of biochemistry /molecular and cell biology /developmental biology.

1) Some research experience since completion of PhD.

2) Background in molecular and cell biology.

3) Knowledge in genetic animal models.

4) At least one publication with 1st authorship would be preferable, but not a requirement.

5) Previous experience with in vivo models, gene manipulation and expression profiling, confocal imaging, disease modelling and primary tissue culture methods would be highly advantageous, but not essential.

We are specifically looking for candidates that are collaborative, with effective communication skills and enjoy working in a team. Proven capacity to design, execute, and interpret your own experiments is essential.

Start date is flexible but can be as early as March 2017.

To apply online for this vacancy and to view further information about the role, please visit: This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the ‘Apply online’ button and register an account with the University’s Web Recruitment System (if you have not already) and log in before completing the online application form.

Please upload your Curriculum Vitae (CV) and a covering letter in the Upload section of the online application to supplement your application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

The closing date for all applications is the Thursday 01 December 2016.

Informal enquiries are also welcome via email to:

Interviews will be held in January 2017. If you have not been invited for interview by 20th December 2016, you have not been successful on this occasion.

Please quote reference PS10618 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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