the community site for and by developmental biologists

Displaying posts with the tag: modelling [Clear Filter]

Creative morphometrics – so many tools, so little time

Posted by on August 4th, 2014

Nowadays, the hardest thing in science is similar to what we experience in daily life, that is organization and choice. In a virtual plethora of techniques, methods and analyses, an aspiring researcher is faced with a flood of information, achievements and tools of the trade. Especially so with computers. But if it wasn’t for this[…]

Raising the Shields!

Posted by on July 23rd, 2014

Turtles are strange organisms, and their development is wonderfully idiosyncratic. What other vertebrate alters its bone development to make an ossified mobile home? The turtle has perplexed biologists for many reasons. Where did turtles come from and to whom are they related? How did this different body plan arise developmentally and evolutionarily? The pieces of[…]

The in silico metamorphosis of the best known metazoan GRN

Posted by on August 31st, 2012

This rather lengthy summary describes a fascinating progress in the field of GRN modeling; it is a review of the article “Predictive computation of genomic logic processing functions in embryonic development”, which appeared few days ago in PNAS. Gene regulatory networks (GRNs) are complex systems of interacting genes that deploy in both space and time[…]

Modeling stem cell population dynamics

Posted by on December 23rd, 2011

Many tissues and organs contain self-renewing stem cell populations that are crucial for their maintenance. Synthesizing the relative effects of anatomical constraints, cell proliferation dynamics and cell fate specification on the overall stem cell population dynamics is challenging, and so we reasoned that dynamic computational models that have the potential to systematically manipulate different influences[…]

Mathematical and Computational Modelling at the BSDB Meeting 2011

Posted by on June 20th, 2011

Here is part 3 of my report on the 2011 BSCB-BSDB Spring Conference this April in Canterbury. In the first part, I covered Mark Krasnow’s amazing opening lecture on lung development, and in part two I introduced this year’s awardees of the BSCB and BSDB honorary medals. Here I’ll highlight some of the talks in[…]

In Development this week (Vol. 137, Issue 22)

Posted by on October 26th, 2010

Research highlights from the current issue of Development: Novel Hh targets fly in Hedgehog (Hh), a secreted morphogen, acts in a paracrine fashion to regulate tissue patterning during embryogenesis. Its tissue-specific effects are mediated by the transcription factor Cubitus interruptus (Ci), but how it exerts such effects is unclear. On p. 3887, Thomas Kornberg and[…]