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Postdoctoral Positions – RNA pathways in development and disease – NIH/NCI

Posted by on April 19th, 2018

We have open postdoctoral positions in our lab. We are looking for researchers interested in understanding the mechanisms through which non-coding RNAs and RNA metabolic pathways regulate gene expression in mammals and how these mechanisms impact animal development and disease. Our lab uses a combination of mouse models and genetic tools together with biochemical and[…]

Dynamic new roles for local RNA regulation in neural stem cells of the developing brain

Posted by on December 22nd, 2016

Debby Silver and Louis-Jan Pilaz Comment on Pilaz, at al. Current Biology. 26(24): 3383-3392   Neurons and glia of the developing brain are produced from an elegant cell cell type called radial glia. These stem cells are fascinating not only because of their inherent multipotent nature, but also because of their unique bipolar morphology. Radial glia are[…]

Free webinar | Single-cell RNA-seq and cell heterogeneity in the central nervous system

Posted by on August 17th, 2016

Register here: http://bit.ly/single_cell_rna_seq_webinar  Interested in understanding RNA-seq and its application to the study of oligodendrocyte heterogeneity? Join Dr Gonçalo Castelo-Branco and Dr Amit Zeisel, of the the Department of Medical Biochemistry and Biophysicsat the Karolinska Institutet, as they discuss the latest developments in single cell RNA-seq. Topics covered will include Technology development, applications, and challenges Investigation of[…]

Seeing cells from a different angle

Posted by on December 7th, 2014

Thanks to microscopy, scientists can compete with the most talented photographers and take the most astonishing pictures! Although I have been focusing on microscopy pictures in this blog, microscopy is not the only way to make pretty pictures of cells. In recent years, the rapid progress in sequencing technology has propelled this technique to the[…]

Piecing together the squint puzzle

Posted by on July 27th, 2012

Here is the backdrop for our recent paper in Development, “Dorsal activity of maternal squint is mediated by a non-coding function of the RNA”:  This work follows up a previous publication from my laboratory where we showed that knock-down of maternal squint (sqt) or ablation of sqt-containing cells led to loss of dorsal structures in[…]

Book review: A molecular view of the life and time of RNA

Posted by on December 8th, 2011

This book review originally appeared in Development. Ilan Davis reviews “Molecular Biology of RNA” (by David Elliot and Michael Ladomery). Book info: Molecular Biology of RNA By David Elliot, Michael Ladomery Oxford University Press (2010) 460 pages ISBN 978-0-19-928837-3 £34.99/$55 (paperback) Following the discovery of the structure of DNA and during the early days of[…]