the community site for and by developmental biologists
the community site for and by developmental biologists
Posted by jorgetorrespaz on December 6th, 2019
The discipline “Evo-devo” studies the developmental basis of morphological evolution. In the field, some original animal models are emerging as interesting model organisms, enriching the knowledge in the field more and more. In the DECA team (Développement et évolution du cerveau antérieur, in French) we use an Evo-devo approach to study the developmental mechanisms responsible[…]
Posted by the Node on October 1st, 2018
This is the latest dispatch from a recipient of a Development Travelling Fellowship, funded by our publisher The Company of Biologists. Learn more about the scheme, including how to apply, here, and read more stories from the Fellows here. Barbara Swierczek I am a PhD student at the University of Warsaw in Poland. In[…]
Posted by Michal Shoshkes-Carmel on June 5th, 2018
The story behind FOXL1+ telocytes You can find our recently published Nature paper here Our story began two decades ago when my mentor, Klaus H. Kaestner, identified and cloned the transcription factor FOXL1, as being expressed in the mesenchyme of the mouse fetal gut (Kaestner et al. 1997). The position of FOXL1+ mesenchymal cells[…]
Posted by jamesglover1 on September 28th, 2017
The story behind our recent paper ‘Hierarchical patterning modes orchestrate hair follicle morphogenesis‘ , finding that distinct patterning mechanisms can co-exist during embryonic organ formation. From the spots of a leopard and stripes on a zebra to the pigmentation of sea shells and arrangement of sand dunes in a desert, repeating patterns are present[…]
Posted by Amy Ruth Reilein on June 16th, 2017
A discussion of “Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signalling,” Nat Cell Biol, 2017. 19(5): p. 433-444. We have recently revised the model of Follicle Stem Cell (FSC) organization in the Drosophila ovary, showing that there is a much larger population of stem cells than formerly realized, that[…]
Posted by MRC Press Office on September 3rd, 2014
Medical Research Council (MRC) scientists have for the first time managed to turn stem cells into the specialised cells that go on to form spinal cord, muscle and bone tissue in the growing embryo. Their discovery could lead to a new way of studying degenerative conditions such as spinal muscular atrophy, which affects the nerve[…]
Posted by Erin M Campbell on May 10th, 2012
The WNT pathway functions in so many processes during development that it is easy to be jealous of its multi-tasking abilities. A recent paper in Development describes the role of WNT signaling in neural stem cell proliferation. WNT signaling plays an important role in neural development, axon guidance, cell polarity, and stem cell biology. WNT[…]
Posted by mattowers on October 26th, 2011
Overview The Research Associate will work in the MRC Centre for Developmental and Biomedical Genetics within the Department of Biomedical Science. The department has an active community of researchers specialising in different aspects of developmental biology. You will take part in a project aiming to understand how cell proliferation is temporally integrated with digit patterning[…]
Posted by Seema Grewal on October 25th, 2011
Here are the highlights from the current issue of Development: The skin-healing touch of Lhx2 Skin repair after injury involves the recruitment of undifferentiated progenitor cells from nearby hair follicles (HFs) into the regenerating epidermis. The bulge and the secondary hair germ of HFs contain distinct populations of epithelial stem cells, and now Vladimir Botchkarev[…]
Posted by Nanette Nascone-Yoder on October 4th, 2011
An NIH-funded postdoctoral position is available in the Nascone-Yoder laboratory at North Carolina State University (Raleigh, NC, USA) to study the role of non-canonical Wnt/PCP signaling in Xenopus gut morphogenesis. The successful applicant will elucidate the cellular and molecular basis of gut tube lumen formation, gut tube elongation and rotation, and/or digestive epithelial morphogenesis. We[…]
