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Building blocks

Posted by on October 19th, 2010

Somites are the building blocks of the vertebrae, skeletal muscle and dermis…literally and figuratively.  Somites define the segmented features of vertebrate embryos, and are repeated blocks of epithelial cells formed sequentially, from anterior to posterior, and at regular intervals on either side of the neural tube.  A paper in the November 1 issue of Development[…]

Axon guidance, synaptic plasticity and regeneration meeting report

Posted by on October 13th, 2010

Cold Spring Harbor axon guidance, synaptic plasticity and regeneration conference meeting report. Great weather, loads of interesting science and plenty of drunken dancing…what more could you want from a conference.

Nippon

Posted by on October 12th, 2010

Dear Reader, My name is Dávid Molnár, I’m a third year Ph.D. student in the Department of Human Morphology and Developmental Biology at Semmelweis University (Budapest, Hungary). I’d like to share the story of my summer internship with You! Thanks to the generous offer of Guojun Sheng, the team leader of the Laboratory for Early[…]

In Development this week (Vol. 137, Issue 21)

Posted by on October 12th, 2010

Here are the research highlights from the current issue of Development: Oct1: essential for trophoblast development Most POU family transcription factors are temporally and spatially restricted during development and play pivotal roles in specific cell fate determination events. Oct1 (Pou2f1), however, is ubiquitously expressed in embryonic and adult mouse tissues; so, does Oct1 have a[…]

Stunning cysts

Posted by on October 6th, 2010

Hello to all of you Node readers!  My name is Erin Campbell and I’m the blogger behind HighMag Blog, a blog that features cell biology images a few times a week.  The great Eva Amsen contacted me about featuring some images on The Node, so I’m excited to be part of this growing community forum. […]

In Development this week (Vol 137, Issue 20)

Posted by on September 28th, 2010

A fateful look at early mouse lineage specification The first cell lineages specified in the mouse embryo are the trophectoderm (TE), which generates the embryonic portion of the placenta, and the inner cell mass (ICM). The ICM subsequently forms the pluripotent epiblast (EPI, which produces the embryo) and the primitive endoderm (PrE, which generates other[…]

Pleiades Promoter Project

Posted by on September 27th, 2010

A recent paper in PNAS describes the development of MiniPromoters: human DNA promoters of less than 4 kb, designed to drive gene expression in specific areas of the brain. The initiative is called the Pleiades Promoter Project, and so far they have confirmed brain-region specific activity in knockin mice for 27 of their MiniPromoters. The[…]

Lasker Awards 2010

Posted by on September 21st, 2010

Today, the Lasker Foundation announced the winners of their 65th annual Lasker Awards, celebrating biomedical research. The winners all contributed to scientific research with strong implications for medical advancements: Albert Lasker Basic Medical Research Award Awarded to: Douglas Coleman & Jeffrey Friedman for the discovery of leptin, the “obesity gene” Lasker-DeBakey Clinical Medical Research Award[…]

On the first days in China…

Posted by on September 17th, 2010

I’m going to collect dates from my travel journal and batch post the most interesting bits.  See this post for my introduction and an explanation for all of this. Enjoy! May 12, 2007 Beijing, China The flight was outrageously long, but uneventful once I boarded. I didn’t find out until I got to Logan airport[…]

Research in the land of rising sun…

Posted by on September 14th, 2010

I am a graduate student from Indian Institute for Science Education and Research (IISER), Pune, India. I wish to share some of my work and life experiences in Japan from a recent visit. Our lab works on development and evolution of insect wings. I am interested in understanding the development of lepidopteran wings using Bombyx[…]