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Displaying posts with the tag: embryogenesis [Clear Filter]

Blastoid: the backstory of the formation of blastocyst-like structure solely from stem cells.

Posted by on June 27th, 2018

In our recently published paper1, we showed that mouse stem cells self-organize into blastocyst-like structures, that we termed blastoids. Because blastoids can be generated in large numbers, can be finely manipulated, and implant in utero, they are a powerful tool to investigate the principles of pre- and post-implantation development. Here is the backstory of our[…]

PhD in nerve/tumor interactions and nervous system development

Posted by on June 18th, 2018

Applications are invited from highly motivated individuals dedicated to peruse a PhD and who are interested in nerve/tumour interactions and nervous system development.    PROJECT DESCRIPTION During tumour progression nerves and tumours interact resulting in tumour cells using nerves as a metastatic route out of the organ, through a process called perineural invasion (PNI). While this[…]

PhD position: Single-cell elucidation of the evolution of an embryonic transcriptional programme

Posted by on April 3rd, 2018

The project: Single-cell approaches are revolutionizing developmental biology. We can now  trace in time the behavior of each cell in a live developing organism (1). In parallel, single-cell transcriptomics and genomics gives access to the transcriptional state of each cell (2). Combination of these two approaches promises to unravel how genomic information translates into individual[…]

PhD position in Queen Mary University of London: Evolution of axis specification in annelid worms

Posted by on February 23rd, 2018

A PhD studentship is available for a project on the evolution of axis specification modes in spiral cleaving animals. The project will focus on the annelid species Owenia fusiformis, which occupies a key phylogenetic position as the sister lineage to all remaining annelids, and it has recently proven very informative for the study of animal[…]

Postdoctoral Fellow in Neurodevelopment

Posted by on January 18th, 2018

Applications are invited from highly motivated individuals who are interested in fundamental mechanisms of neuronal migration and axon guidance. The main focus of our research is to understand the molecular and cellular mechanisms underlying the development of neural circuits using the embryonic spinal cord as a model system (http://www.ucmm.umu.se/english/research/sara-wilson/). The fellowship is funded for two[…]

This year for Christmas, gift yourself with an amazing experience. Apply today for the 2018 CSHL Cell and Developmental Biology of Xenopus course.

Posted by on December 18th, 2017

The end of the year is quickly approaching, and if you are anything like me you are scrambling to try to get as much work done as possible before your holiday break. But while this frequently entails getting papers submitted, committee meetings completed, and experiments wrapped up, I also take the opportunity to reflect on[…]

FASEB 2017 BioArt Winners

Posted by on December 13th, 2017

Here at the Node we are always on the lookout for beautiful developmental biology images and videos, and love our science art (see here, here, here, here and here!). So we were excited to hear FASEB announce the winners of their 2017 BioArt competition.  As well as gorgeous images (see below) there was this wonderful video – the[…]

The people behind the papers – Qiang Shao, Stephanie Herrlinger & Jian-Fu (Jeff) Chen

Posted by on November 16th, 2017

Zika infection in humans is associated with birth defects including microcephaly. Zika has two major lineages – the Asian lineage, which has been associated with birth defects, and the African lineage, which has not – but the relative effects of each strain on brain development, and the effects of the related dengue virus that co-circulates with[…]

Glia lead the way for pioneers to build the brain neuropil in C. elegans

Posted by on October 20th, 2017

It’s all about the wires. But what about the glue? Networks make us who we are. I am not talking about social networks but about neural networks that define how we perceive the world and how we act. For a century, neuroscientists have sought to understand functions of neural networks in condition and how such[…]

The right information

Posted by on October 19th, 2017

Oscar H. Ocaña and M. Angela Nieto Comment on “A right-handed signalling pathway drives heart looping in vertebrates”. Nature 549, 86-90 (2017).   A fundamental aspect of vertebrates is their external bilateral symmetry, which has to some extent shaped evolutionary success. Not only is beauty associated with symmetry, enhancing an individual’s chance of mating but[…]