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Displaying posts with the tag: heart [Clear Filter]

Looking back on the adventure: exploring cell fate conversion with single cell RNA-seq

Posted by on November 21st, 2017

The story behind our recent paper: Liu Z*, Wang L*, Welch JD*, Ma H, Zhou Y, Vaseghi HR, Yu S, Wall JB, Alimohamadi S, Zheng M, Yin CY, Shen WN, Prins JF, Liu JD, Qian L (2017). Single cell transcriptomics reconstructs lineage conversion from fibroblast to cardiomyocyte. Nature, 551, 100-104 *: co-first author. https://www.nature.com/articles/nature24454  […]

Mechanisms for asymmetric heart morphogenesis: About Nodal and tissue intrinsic forces

Posted by on December 11th, 2013

Although we all appear symmetrical from the outside, the organization of our internal organs and organ structure are highly asymmetric. Proper asymmetric positioning and patterning of our organs is very important for correct function, and loss of this asymmetry during organ formation can lead to a variety of serious congenital diseases.  Our recent study identifies[…]

Proepicardial cells go for a swim: how fluid flows guide epicardial progenitors to the heart

Posted by on September 12th, 2013

The epicardium, the layer of cells covering the myocardium, plays an essential role in heart maturation and formation of the heart valves and coronary vasculature. It derives from the proepicardium (PE), a cluster of cells emerging from the inner lining of the pericardial wall, in which the heart is located. During development, PE cells need[…]

CNIC conference: Cardiovascular Development, Disease and Repair

Posted by on September 10th, 2013

CNIC conference: Cardiovascular Development, Disease and Repair 8-9th November 2013 Centro Nacional de Investigaciones Cardiovasculares CNIC, Madrid, Spain. Abstract submission deadline: 20th October 2013 For more information and registration please visit the following webpage: http://www.cnic-conference.com/     Cardiovascular diseases are the leading cause of death worldwide and their treatment is associated with an enormous economic[…]

Postdoc position

Posted by on January 4th, 2013

A postdoctoral position is available in the laboratory of Dr. Sophie Astrof to study roles of cell-extracellular matrix interactions in cardiovascular development and disease using mouse model system. The research will involve investigation of the role of extracellular matrix in orchestrating signaling/communication between various progenitor cell populations during morphogenesis of the aortic arch arteries.  In[…]

PhD student position at the British Heart Foundation Regenerative Medicine Laboratory

Posted by on January 26th, 2012

  EU Initial Training Network searches for 1 PhD Student CardioNeT – Our Initial Training Network in Cardiovascular Research offers 1 PhD student position at the British Heart Foundation Regenerative Medicine Laboratory, Department of Physiology, Anatomy and Genetics, University of Oxford, UK. Funded by EU’s FP7, CardioNeT comprises twelve partners from both the academic and[…]

Embryonic development informs adult heart repair

Posted by on June 9th, 2011

After a heart attack, heart muscle is irreparably damaged, but a paper in Nature now reports that adult mouse hearts have a source of progenitor cells that can form new muscle cells after heart injury. A few years ago, studies showed that embryonic epicardial progenitor cells contribute to the cardiomyocyte lineage in developing mouse hearts.[…]

Mapping the cardiac neural crest in the frog’s heart

Posted by on April 27th, 2011

The Node’s staff asked me to write a short “behind the scenes” on our paper just released in the May 15 issue of Development, “Cardiac neural crest is dispensable for outflow tract septation in Xenopus” http://dev.biologists.org/lookup/doi/10.1242/dev.061614 In the summer of 2008 when Dr. Young-Hoon Lee joined my laboratory from Chonbuk National University for a sabbatical[…]

In Development this week (Vol. 138, Issue 9)

Posted by on April 12th, 2011

Here are the research highlights from the current issue of Development: Cranial neural crest development: p53 faces up The tumour suppressor p53 plays multiple roles in the prevention of cancer but its developmental functions are less clear. Here (see p. 1827), Eldad Tzahor and colleagues elucidate the key role that p53 plays in craniofacial development.[…]

In Development this week (Vol 137, Issue 19)

Posted by on September 7th, 2010

Here are the research highlights from the current issue of Development: Nr5a receptors reset EpiSC pluripotency Rodent embryonic stem (ES) cells that are derived from blastocysts self-renew without mitogenic growth factors and robustly colonize chimaeras, whereas egg cylinder-derived stem cells (EpiSCs) require fibroblast growth factor and contribute poorly to chimaeras. Nevertheless, expression of a single[…]