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Gaining traction: What Hippos can teach us about vertebrate embryonic morphogenesis

Posted by on January 19th, 2018

In our recently published paper, we discovered that the Hippo pathway transcription factors have an unexpected role in creating the conditions for the zebrafish body to extend posteriorly during embryogenesis, as well to form the precursors of the dorsal and ventral fins. Here is the backstory of the twists and turns that lead to these[…]

In Development this week (Vol. 138, Issue 10)

Posted by on April 26th, 2011

Here are the research highlights from the current issue of Development: FatJ keeps neural progenitor pools in shape The correct development and functioning of the spinal cord depends on the patterning, proliferation and differentiation of neural progenitor cell cohorts along the dorsoventral axis of the neural tube. But how are the numbers of these cells[…]

In Development this week (Vol. 138, Issue 9)

Posted by on April 12th, 2011

Here are the research highlights from the current issue of Development: Cranial neural crest development: p53 faces up The tumour suppressor p53 plays multiple roles in the prevention of cancer but its developmental functions are less clear. Here (see p. 1827), Eldad Tzahor and colleagues elucidate the key role that p53 plays in craniofacial development.[…]

In Development this week (Vol. 138, Issue 5)

Posted by on February 8th, 2011

Here are the highlights from the current issue of Development: From pluripotent to pancreatic fates A reliable method for generating insulin-producing β-cells from human pluripotent stem cells (hPSCs) would provide new therapeutic options for people with diabetes. So far, no-one has developed such a method but, on p. 861, Gordon Keller and colleagues provide new[…]

In Development this week (Vol. 138, Issue 1)

Posted by on December 7th, 2010

The first issue of 2011 is out now…here are the highlights: Geminin control of lineage commitment The transition between pluripotency and multi-lineage commitment during early embryogenesis must be closely regulated to ensure correct spatial and temporal patterning of the embryo. But what regulates this crucial transition? According to Kristen Kroll and co-workers, part of the[…]

In Development this week (Vol. 137, Issue 24)

Posted by on November 23rd, 2010

Pak1-ing a punch in lumen formation The generation and maintenance of correct lumen size and shape is essential for the function of tubular organs. Now, Monn Monn Myat and co-workers report that p21-activated kinase (Pak1) plays a novel role during lumen formation in Drosophila embryonic salivary glands (see p. 4177). The researchers show that Pak1[…]

In Development, Vol 137 (Issue 14)

Posted by on June 23rd, 2010

Here are the research highlights from the current issue of Development. You can find these on the Development site but we thought it would be useful to have them posted on the Node, too. Brainy signals for actin dynamics During brain development, neurite outgrowth and neuronal migration establish the brain architecture needed for brain function.[…]