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The people behind the papers – Kana Ishimatsu, Tom Hiscock & Sean Megason

Posted by on June 12th, 2018

Somites are segmented structures  which give rise to numerous tissues in the vertebrate body. It has long been observed that somites scale in size with the overall size of the embryo, both as development proceeds and between individuals of different sizes, but the molecular underpinnings of this process have remained controversial. A new paper in[…]

The people behind the papers – Ross Carter, Yara Sánchez-Corrales, Verônica Grieneisen & Athanasius (Stan) Marée

Posted by on November 29th, 2017

Pavement cells in plant leaves were identified as a puzzle which deviated  from normal cell shape rules by D’Arcy Thompson in his classic text On Growth and Form. Now modern approaches allow researchers to revisit these problems and try to uncover the rules that govern pavement cell topology during leaf development. This week we feature a[…]

Paris – Cambridge – Paris: a Megakaryocyte story

Posted by on November 14th, 2016

The first news came as a shock: so the British Railways are not always perfectly on time? For an Italian, that was a massive cultural shock. The second one was even more surprising: English weather is not that bad; actually, it is better than Parisian weather. But still, I was unable, on the train from Paris to Cambridge, to stop thinking about how[…]

Obituary: Hans Meinhardt (1938-2016)

Posted by on March 29th, 2016

This obituary first appeared in Development.   Patrick Müller and Christiane Nüsslein-Volhard reflect on the life and career of their colleague Hans Meinhardt.   Hans Meinhardt, a pioneer in the field of theoretical biology, died on 11 February 2016 in Tübingen. He made numerous important contributions to developmental biology by spearheading the use of mathematical models[…]

Applying tandem timers to measure signalling and gene expression dynamics in developing embryos

Posted by on January 11th, 2016

The signalling systems that conduct the orchestra of embryonic development are fantastically complex and dynamic. We owe much of our knowledge of in vivo signalling dynamics to advances in microscopy and protein tagging with fluorescent reporters that have allowed visualization of signalling proteins. Looking forward, however, it is clear that simply analyzing the localization patterns[…]

AI tackles variability of metastatic conversion triggered by bioelectric disregulation

Posted by on November 7th, 2015

  One of the most important problems in experimental biology has to do with variability / heterogeneity (Rubin, 1990): why do different organisms react differently to the same perturbation or reagent? This is observed even among clonal populations (e.g., cohorts of planarian flatworms descended from the fission of 1 animal and living in the same[…]

Computing the worm: artificial intelligence approaches to planarian regeneration and beyond

Posted by on October 30th, 2015

Pattern formation and regulation emerges from cellular activity determined by specific biophysical and genetic rules. A major challenge for developmental biology, biomedicine, and synthetic bioengineering is this highly indirect (Lobo et al., 2014b) relationship between the rules that govern processes at the lower scales, and the anatomical outcomes observed at the macroscopic scale. It is[…]

2016 Workshop – Tissue mechanics in morphogenesis: Focus on theoretical modeling – May 9-13, 2016, Paris

Posted by on October 9th, 2015

We are happy to announce the forthcoming workshop on « Tissue mechanics in morphogenesis: Focus on theoretical modeling ». This is an informal workshop open to anyone, theorist or experimentalist, who is developing or is using theoretical models to understand tissue mechanics during morphogenesis. How tissues acquire and maintain their shape is a crucial question[…]

EmbryoMaker: a general modeling framework to simulate developing systems and perform experiments in silico.

Posted by on October 4th, 2015

One of the main challenges of Developmental Biology is to understand the complex developmental mechanisms giving rise to different organs or whole organisms. In most cases, these involve the interplay between cell-cell signalling and cell and tissue movements driven by one or several cell behaviours (such as cell proliferation, cell migration, etc.). Cell signalling will[…]

“Eppur (non) si muove”: why cellular movements may not be essential to the formation of Turing patterns in biology.

Posted by on September 23rd, 2015

D. Bullara* and Y. De Decker *   When Catarina Vicente (Community Manager of “The Node”) proposed us to write a post about our recent paper on pattern formation in zebrafish [Bullara2015] we were very glad for the opportunity she was giving us to tell the background story about our work in this blog. We[…]