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Displaying posts with the tag: mouse [Clear Filter]

Workshop on HREM imaging and mouse phenotyping

Posted by on August 8th, 2017

Deciphering the Mechanisms of Developmental Disorders (DMDD) is a large-scale imaging and phenotyping  programme for genetically modified mouse embryos. For embryos at E14.5, the key imaging technique is High Resolution Episcopic Microscopy (HREM), and the resulting images are used to comprehensively phenotype the embryos using a systematic approach.     With a combination of lectures,[…]

9.5 million knockout mouse embryo images now available

Posted by on July 20th, 2017

A new set of DMDD embryo and placenta data has been released, taking our total dataset to 9.5 million images of around 1300 embryos. DMDD is a primary screen of embryonic lethal knockout mice, and all data can be freely accessed at dmdd.org.uk. Detailed phenotypes are available for embryos from 73 different knockout lines, and[…]

Matching neurons to limbs: an evolutionary perspective on motor system development

Posted by on February 24th, 2017

Comment on “Divergent Hox Coding and Evasion of Retinoid Signaling Specifies Motor Neurons Innervating Digit Muscles” Neuron 93, 1–14, February 22, 2017. Alana I. Mendelsohn, Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University Jeremy S. Dasen, Department of Neuroscience, NYU Thomas M. Jessell, Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University[…]

Why are geneticists measuring the webbing between mouse embryo fingers?

Posted by on February 21st, 2017

A new paper published in Journal of Anatomy shows that measuring the amount of inter-digital webbing in mouse embryos between 14 and 15 days gestation is the best way to find out their exact stage of development. So why is this important to a geneticist? If we want to discover a causal link between a gene[…]

New phenotype dataset available for embryonic-lethal mouse knockouts

Posted by on December 1st, 2016

    This post originally appeared on Annotations, the DMDD blog.   New image and phenotype data for embryos and placentas from embryonic lethal knockout mouse lines has been made available on the DMDD website today. The knockout data includes the ciliary gene Rpgrip1l as well as Atg16l1, a gene encoding a protein that forms[…]

Postdoctoral Position in Signaling Mechanisms

Posted by on October 25th, 2016

Postdoctoral Position open at: Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California   An NIH-funded postdoctoral position is available to investigate the signaling functions of retinoic acid (RA) during mouse embryo development. Our laboratory has reviewed recent advances in this field: Cunningham, T.J. and Duester, G. Mechanisms of retinoic acid signalling and its roles[…]

New phenotype screen examines causes of neonatal death

Posted by on October 4th, 2016

This post first appeared on Annotations, the DMDD blog (blog.dmdd.org.uk). Around a third of targeted gene knockouts in mice are embryonic-lethal. But not all deaths occur during gestation – a significant number of gene knockouts result in death at or shortly after the time of birth. Mice from these knockout lines provide a valuable animal[…]

New data reveals gene expression during mouse embryo development

Posted by on September 29th, 2016

This article was originally posted on the DMDD website dmdd.org.uk Knowing the ‘normal’ expression of genes during embryo development is key to understanding the differences that occur due to genetic mutations. As part of work to understand the underlying transcriptional processes for developing embryos from knockout mouse lines, DMDD has now released a gene expression[…]

Postdoctoral Opportunities at the National Institutes of Health

Posted by on September 28th, 2016

ROLE of THYROID HORMONE in MOUSE INTESTINAL DEVELOPMENT and REGENERATION. Thyroid hormone (T3) is known to be critical for postembryonic development in mammals (around birth). This laboratory has been taking a multi-faceted approach to investigate the function of T3 and T3 receptors (TRs) in vivo by using Xenopus and mouse as models. A major recent focus is on how[…]

A Tale of Trunks or Zen and the art of doing a PhD

Posted by on September 1st, 2016

The story of this paper is also the story of my PhD. It begins as most papers and PhDs do: with a distinct and often unrelated starting project or plan. It is great to have a plan. But time and luck and data bend and twist the plan; until it finally breaks and you end[…]