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Displaying posts with the tag: mouse [Clear Filter]

Mouse embryology

Posted by on October 30th, 2018

Practical training course March13-15, 2019 Strasbourg, France Program and registration (No Ratings Yet) Loading…

Of mice and chicks…

Posted by on October 1st, 2018

This is the latest dispatch from a recipient of a Development Travelling Fellowship, funded by our publisher The Company of Biologists. Learn more about the scheme, including how to apply, here, and read more stories from the Fellows here.   Barbara Swierczek   I am a PhD student at the University of Warsaw in Poland. In[…]

Going out on a limb to study organ growth

Posted by on August 2nd, 2018

Alexandra Joyner and Alberto Roselló-Díez tell us the story behind their recent paper in PLoS Biology1.   Today we have tried a new experiment (we cannot help it). Instead of elaborating too much on the scientific aspect of our recent paper about the control of organ growth in mammals1, we decided to tell the personal[…]

NC3Rs 2019 Funding Highlight Notice Launch

Posted by on July 13th, 2018

The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) is running a workshop bringing together rodent and non-mammalian model organism users, facilitating research partnerships and encouraging the development of new and innovative applications of non-mammalian organisms.     There will be an opportunity to: Hear from rodent and non-mammalian model organism users. Learn[…]

Blastoid: the backstory of the formation of blastocyst-like structure solely from stem cells.

Posted by on June 27th, 2018

In our recently published paper1, we showed that mouse stem cells self-organize into blastocyst-like structures, that we termed blastoids. Because blastoids can be generated in large numbers, can be finely manipulated, and implant in utero, they are a powerful tool to investigate the principles of pre- and post-implantation development. Here is the backstory of our[…]

New embryo phenotype data from the DMDD programme

Posted by on June 15th, 2018

Following our latest data release, the DMDD website (dmdd.org.uk) now contains detailed phenotype data for nearly 700 embryos from 82 different knockout mouse lines. Highlights include the identification of limb defects and cysts in Col4a2 knockouts and replication of the major features of Meckel syndrome in B9d2 knockouts. We have begun to add immunohistochemistry image[…]

Polarizing morphogenesis: epithelia dance the polonaise

Posted by on June 13th, 2018

The story behind our recent paper: Counter-rotational cell flows drive morphological and cell fate asymmetries in mammalian hair follicles. Maureen Cetera, Liliya Leybova, Bradley Joyce & Danelle Devenport, Nature Cell Biology.    Planar cell polarity (PCP) is a fascinating biological problem because it spans such vast biological scales, from nanometers to meters of spatial organization. When[…]

Rare Is Everywhere

Posted by on June 5th, 2018

The story behind FOXL1+ telocytes You can find our recently published Nature paper here   Our story began two decades ago when my mentor, Klaus H. Kaestner, identified and cloned the transcription factor FOXL1, as being expressed in the mesenchyme of the mouse fetal gut (Kaestner et al. 1997). The position of FOXL1+ mesenchymal cells[…]

Postdoctoral Positions – RNA pathways in development and disease – NIH/NCI

Posted by on April 19th, 2018

We have open postdoctoral positions in our lab. We are looking for researchers interested in understanding the mechanisms through which non-coding RNAs and RNA metabolic pathways regulate gene expression in mammals and how these mechanisms impact animal development and disease. Our lab uses a combination of mouse models and genetic tools together with biochemical and[…]

Postdoc position (Francis Crick Institute, London): Developmental origins of health and longevity

Posted by on February 20th, 2018

An exciting opportunity to be part of a pioneering biomedical research institute, dedicated to innovation and science. A postdoctoral research post in the laboratory of Dr. Alex P. Gould is now available. We are looking for a highly motivated researcher to identify the, as yet unknown, molecular mechanisms by which dietary nutrients and oxidative stress[…]