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Displaying posts with the tag: patterning [Clear Filter]

How do pigment cells wander around?

Posted by on June 29th, 2018

The story behind melanocyte BACE2, posted by Yan Zhang and Richard White. You can read our recently published full article at Developmental Cell using this link.   Our story began six years ago when my mentor, Dr. Richard White, opened the zebrafish facility and showed me those swimming creatures. He pointed to one type with pigmented[…]

Lighting Up the Central Dogma in Development

Posted by on June 19th, 2018

We recently published a manuscript in Cell that describes a method to image transcription factor concentration dynamics in real time, in living embryos, using a nanobody-based protein tag that we call the “LlamaTag.” We were particularly excited about these investigations because this new technology overcomes a major technical obstacle to understanding how gene-expression dynamics are[…]

Borders and communities: solving old puzzles with new tools

Posted by on May 10th, 2018

An important question in developmental biology is how regions with distinct identity are established despite the intermingling of cells that occurs during growth and morphogenesis. Our recent work revisited some old studies of how the vertebrate hindbrain is patterned, and found that sharp and homogeneous segments are formed through a combination of identity switching and[…]

The people behind the papers – David Turner & Peter Baillie-Johnson

Posted by on November 6th, 2017

Embryonic patterning is dependent on the establishment of the anteroposterior (AP) and dorsoventral axes early in development. In mammals this occurs by a breaking of symmetry in the epiblast, however the molecular mechanisms controlling this process are still not fully understood. This week we feature a paper published in the latest issue of Development that[…]

The people behind the papers: Dae Seok Eom & David Parichy

Posted by on April 7th, 2017

Macrophages are usually associated with immunity, but have increasingly appreciated functions in development and homeostasis. This week we meet the authors of a recent Science paper that identified a role for macrophages in zebrafish stripe patterning, revealing a remarkable ‘relay’ mechanism whereby macrophages help one type of cell signal to another via cytoplasmic extensions. Postdoc[…]

How a cell becomes a giant: a fluctuation-driven patterning mechanism

Posted by on March 22nd, 2017

Heather M. Meyer1, José Teles2, and Pau Formosa-Jordan2   1 Weill Institute for Cell and Molecular Biology and the graduate field of Genetics, Genomics, and Development, Cornell University, Ithaca, NY, 14853 USA 2 Sainsbury Laboratory, University of Cambridge, Cambridge CB2 1LR, UK   Comment on: Heather M. Meyer*, José Teles*, Pau Formosa-Jordan*, Yassin Refahi, Rita[…]

An interview with Mike Levine

Posted by on October 20th, 2015

This interview first featured in Development.   Mike Levine, director of the Lewis-Sigler Institute for Integrative Genomics at Princeton University, is a developmental biologist who has dedicated his career to understanding how gene expression is regulated during development. Some of his most significant research, such as the co-discovery of the homeobox genes and his work on[…]

Towards a synthetic embryo

Posted by on September 24th, 2014

Waddington, whose writings on the epigenetic landscape continue to influence developmental biology to this day, called the developing embryo “the most intriguing object that nature has to offer”(Waddington, 1966). The mechanisms of pattern formation and morphogenesis have fascinated biologists for centuries. One question that is difficult to answer is what are the minimal requirements for[…]

Mouse Molecular Genetics 2013

Posted by on June 24th, 2013

Mouse Molecular Genetics 18-21 September 2013 Wellcome Trust Genome Campus, Hinxton, Cambridge, UK Abstract and Bursary deadline: 19 July | Registration deadline: 7 August We are pleased to announce that the 26th annual Mouse Molecular Genetics meeting will be held at the Wellcome Trust Genome Campus, from 18 to 21 September 2013. This meeting is[…]

Retinoic Acid Gradient Directly Visualized During Zebrafish Gastrulation

Posted by on April 11th, 2013

Retinoic acid is one of the most important signaling molecules during development, and that the embryo gets the right levels of this small molecule is critical. Too much or too little, and the basic patterning of the nervous system and many other organs goes terribly wrong. Indeed, you have to think for a bit to[…]