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Displaying posts with the tag: patterning [Clear Filter]

The people behind the papers: Dae Seok Eom & David Parichy

Posted by on April 7th, 2017

Macrophages are usually associated with immunity, but have increasingly appreciated functions in development and homeostasis. This week we meet the authors of a recent Science paper that identified a role for macrophages in zebrafish stripe patterning, revealing a remarkable ‘relay’ mechanism whereby macrophages help one type of cell signal to another via cytoplasmic extensions. Postdoc[…]

How a cell becomes a giant: a fluctuation-driven patterning mechanism

Posted by on March 22nd, 2017

Heather M. Meyer1, José Teles2, and Pau Formosa-Jordan2   1 Weill Institute for Cell and Molecular Biology and the graduate field of Genetics, Genomics, and Development, Cornell University, Ithaca, NY, 14853 USA 2 Sainsbury Laboratory, University of Cambridge, Cambridge CB2 1LR, UK   Comment on: Heather M. Meyer*, José Teles*, Pau Formosa-Jordan*, Yassin Refahi, Rita[…]

An interview with Mike Levine

Posted by on October 20th, 2015

This interview first featured in Development.   Mike Levine, director of the Lewis-Sigler Institute for Integrative Genomics at Princeton University, is a developmental biologist who has dedicated his career to understanding how gene expression is regulated during development. Some of his most significant research, such as the co-discovery of the homeobox genes and his work on[…]

Towards a synthetic embryo

Posted by on September 24th, 2014

Waddington, whose writings on the epigenetic landscape continue to influence developmental biology to this day, called the developing embryo “the most intriguing object that nature has to offer”(Waddington, 1966). The mechanisms of pattern formation and morphogenesis have fascinated biologists for centuries. One question that is difficult to answer is what are the minimal requirements for[…]

Mouse Molecular Genetics 2013

Posted by on June 24th, 2013

Mouse Molecular Genetics 18-21 September 2013 Wellcome Trust Genome Campus, Hinxton, Cambridge, UK Abstract and Bursary deadline: 19 July | Registration deadline: 7 August We are pleased to announce that the 26th annual Mouse Molecular Genetics meeting will be held at the Wellcome Trust Genome Campus, from 18 to 21 September 2013. This meeting is[…]

Retinoic Acid Gradient Directly Visualized During Zebrafish Gastrulation

Posted by on April 11th, 2013

Retinoic acid is one of the most important signaling molecules during development, and that the embryo gets the right levels of this small molecule is critical. Too much or too little, and the basic patterning of the nervous system and many other organs goes terribly wrong. Indeed, you have to think for a bit to[…]

Postdoctoral position – MRC Department of Biomedical/Developmental Genetics, University of Sheffield, UK

Posted by on October 26th, 2011

Overview The Research Associate will work in the MRC Centre for Developmental and Biomedical Genetics within the Department of Biomedical Science.  The department has an active community of researchers specialising in different aspects of developmental biology.  You will take part in a project aiming to understand how cell proliferation is temporally integrated with digit patterning[…]

Post-doc position: Canada

Posted by on July 28th, 2011

I currently have an opening in my research group for a post-doc to investigate the development of the vertebrate skeleton.  Our lab studies the development of the neural crest derived skeleton in a comparative manner in chicken and fish embryos (zebrafish and Mexican tetra).   This position will focus on the signals involved in the patterning[…]

Mathematical and Computational Modelling at the BSDB Meeting 2011

Posted by on June 20th, 2011

Here is part 3 of my report on the 2011 BSCB-BSDB Spring Conference this April in Canterbury. In the first part, I covered Mark Krasnow’s amazing opening lecture on lung development, and in part two I introduced this year’s awardees of the BSCB and BSDB honorary medals. Here I’ll highlight some of the talks in[…]

The story behind the screen – flashbacks from the first RNAi screen in a whole vertebrate

Posted by on May 9th, 2011

The story of our recently released Development paper ‘FatJ acts via the Hippo mediator Yap1 to restrict the size of neural progenitor cell pools’ ( involves hundreds of dozens of fresh free-range eggs and not trivial amounts of time spent peering down a microscope. I have written this with Nick van Hateren, who is the joint first author of this paper along with me.