The Blythe Lab at Northwestern University seeks to recruit a motivated postdoctoral fellow to investigate chromatin dynamics in early Drosophila embryogenesis.
Research in the Blythe Lab focuses on a critical period of embryogenesis termed the maternal-to-zygotic transition (MZT). During this time, embryos establish an initial ‘ground state’ of chromatin structure that defines the initial cis-regulatory landscape underlying the embryo’s first cell fate decisions. We are interested both in how the initial state is established and how this constrains the interpretation of developmental cues during pattern formation. To study this question, we apply a combination of genetic, genomic, and quantitative imaging approaches to understand the mechanisms that shape the embryonic chromatin landscape.
Projects are available in three major areas at the interface of developmental biology, epigenetics, and systems biology: 1) Temporal control of zygotic genome activation; 2) Patterning-dependent chromatin remodeling and gene regulatory network function; 3) Conflicts between DNA replication and transcription.
We are particularly interested in candidates with experience in genomic approaches (RNA-, ChIP-, or ATAC-seq), analysis of genomic data, quantitative confocal microscopy, biophysical approaches, and/or Drosophila genetics. The position available immediately.
Soluri et al, Biorxiv 2019 (https://doi.org/10.1101/852707)
Hannon et al, eLife 2017 (https://doi.org/10.7554/eLife.28275)
Blythe and Wieschaus, eLife 2016 (https://doi.org/10.7554/eLife.20148)
Blythe and Wieschaus, Cell 2015 (https://doi.org/10.1016/j.cell.2015.01.050)
Interested applicants should forward a cover letter, CV, and list of three references to:
Shelby A. Blythe, Ph.D.
Department of Molecular Biosciences
Evanston, IL 60202