the community site for and by developmental biologists

Displaying posts with the tag: retina [Clear Filter]

The people behind the papers – Li-Juan Duan and Guo-Hua Fong

Posted by on May 23rd, 2019

This interview, the 62nd in our series, was recently published in Development Vascular development critically involves pruning, which helps to remodel an immature network containing excess microvessels into a mature and functioning one. The mechanisms of vascular remodelling and the relationship between the endothelial cells and the other cell types with which they are closely associated are,[…]

Obituary: Jarema Malicki (1965-2019)

Posted by on March 6th, 2019

This obituary by Colin Johnson recently appeared in Development. Jarema Malicki, a pioneer in developmental studies of the vertebrate retina, died on 4th January 2019, shortly after being diagnosed with cancer. Here, I reflect on Jarema’s life and work, with a particular focus on his research interests in zebrafish as a model organism for vertebrate[…]

Staying in shape

Posted by on October 5th, 2018

If you’re into developmental biology, chances are you’ve spent some time in your life thinking about how cells change the shapes of tissues. What would cells need to do in order to prevent change of tissue shape, though? In the text below, I summarize my thoughts on why the question of not changing shape during[…]

An interview with Bill Harris

Posted by on July 6th, 2017

This interview by Aidan Maartens originally appeared in Development, Volume 143, Issue 13.    William ‘Bill’ Harris is Head of the Department of Physiology, Development and Neuroscience at the University of Cambridge, UK, and a Fellow of both the Royal Society and Academy of Medical Sciences. His lab works on the development of the vertebrate[…]

Stone Soup Eyes

Posted by on April 16th, 2014

Another installment from the Developmental Neurobiology Students at Reed College. Hope you enjoy! It’s not often that you get to recount the classic tale of Stone Soup when thinking about developmental biology, but that’s exactly what we did when discussing an almost classic 2011 Nature paper from Yoshiki Sasai’s group. In the story, a grumpy[…]

Seeing a future for retinal regeneration

Posted by on June 14th, 2013

Regeneration is a superpower not just reserved for superheroes—salamanders and newts are able to regenerate lost limbs and tails, and fish can regenerate new retinal neurons after injury to the eye.  Mammals have limited ability to regenerate retinal neurons, but a recent paper in Development finds that a single transcription factor may be able to[…]

In Development this week (Vol. 138, Issue 2)

Posted by on December 21st, 2010

Boning up on stem cell Igf2-P2 function The insulin-like growth factor (IGF)/insulin signalling pathway regulates cell proliferation, differentiation, aging and life span. During embryonic development, transcription of the mouse and human Igf2 gene is tightly regulated by four alternative promoters whose specific roles are unclear. Now, Sylvie Nathalie Hardouin and colleagues reveal that the transcriptional[…]