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Forgotten classics: Cut and paste embryology

Posted by on February 2nd, 2017

Hörstadius, S. 1939. The mechanics of sea urchin development, studied by operative methods. Biological Reviews 14(2):132-179. Recommended by Bob Goldstein, University of North Carolina at Chapel Hill   Sven Hörstadius stands alongside the likes of Boveri, Spemann, Mangold and Driesch as a giant of experimental embryology in the first half of the twentieth century. While[…]

Forgotten classics- Principles of morphogenesis

Posted by on March 10th, 2016

  Gustafson, T., Wolpert, L. (1967) Cellular movement and contact in sea urchin morphogenesis. Biological reviews of the Cambridge Philosophical Society 42, 442-498. Recommended by Thomas Lecuit (IBDM- Developmental Biology Institute of Marseille)   In the beginning of his famous 1969 paper on positional information, Lewis Wolpert states that “the central problem of the development[…]

An interview with Lewis Wolpert

Posted by on August 4th, 2015

This interview first featured in Development.   Lewis Wolpert is a retired developmental biologist who, over his long career, has made many important contributions to the field, from his French Flag model and the concept of positional information to the famous quote that it is “not birth, marriage or death, but gastrulation which is truly the[…]

A Day in the Life of a Sea Urchin Lab

Posted by on February 17th, 2014

Hi! I’m Tanvi, a third year PhD student in the Ettensohn Lab at Carnegie Mellon University in Pittsburgh, Pennsylvania, USA. The big question our lab is concerned with is how the genome encodes morphogenesis. We use transcriptional gene regulatory networks as a tool to study how transcription factors and signaling pathways regulate the expression of[…]

The in silico metamorphosis of the best known metazoan GRN

Posted by on August 31st, 2012

This rather lengthy summary describes a fascinating progress in the field of GRN modeling; it is a review of the article “Predictive computation of genomic logic processing functions in embryonic development”, which appeared few days ago in PNAS. Gene regulatory networks (GRNs) are complex systems of interacting genes that deploy in both space and time[…]

In Development this week (Vol. 138, Issue 17)

Posted by on August 9th, 2011

Here are the highlights from the current issue of Development: Human embryos make an early transcriptional start Human preimplantation development is a highly dynamic process that lasts about 6 days. During this time, the embryo must complete a complex program that includes activation of embryonic genome transcription and initiation of the pluripotency program. Here, Juan[…]