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Displaying posts with the tag: signalling [Clear Filter]

The people behind the papers – Guillaume Blin, Manuel Thery & Sally Lowell

Posted by on September 21st, 2018

During early mouse development, a series of signalling interactions breaks the symmetry of the egg cylinder, spatially organising the embryo into territories that define the future axes of the body. Symmetry breaking can also be observed in embryonic stem cell (ESC) colonies cultured on micropatterned substrates, which thus provide a powerful system to test the[…]

Borders and communities: solving old puzzles with new tools

Posted by on May 10th, 2018

An important question in developmental biology is how regions with distinct identity are established despite the intermingling of cells that occurs during growth and morphogenesis. Our recent work revisited some old studies of how the vertebrate hindbrain is patterned, and found that sharp and homogeneous segments are formed through a combination of identity switching and[…]

The people behind the papers – Ivette Olivares-Castiñeira & Marta Llimargas

Posted by on July 21st, 2017

The Drosophila tracheal system is a powerful model for understanding the genetic and cell biological control of tubulogenesis. In their new PLoS Genetics paper, Ivette Olivares-Castiñeira and her PI Marta Llimargas of the Molecular Biology Institute of Barcelona connect EGFR signalling to intracellular cell trafficking during tracheal morphogenesis. We caught up with Marta and Ivette to hear the story behind[…]

A call for abstracts: BMP Signalling in Cancer conference

Posted by on November 25th, 2015

15—17 March 2016 St. Catharine’s College, Cambridge, UK   The aim of this Biochemical Society focused meeting is to explore the mechanisms of BMP signal transduction and regulation of signalling, and discuss how genetic and epigenetic alterations result in aberrant signalling and how this leads to cancer. The BMP signalling pathway is a key therapeutic[…]

Signalling 2015 conference: abstract deadline fast approaching

Posted by on June 23rd, 2015

Signalling 2015: Cellular Functions of Phosphoinositides and Inositol Phosphates 1—4 September 2015 Robinson College, Cambridge, UK Join the Biochemical Society and FEBS in Robinson College, Cambridge, this September for the Signalling 2015: Cellular Functions of Phosphoinositides and Inositol Phosphates conference. This meeting will bring together world-leading and early career scientists to discuss the latest research into the[…]

PhD opportunity available in Dundee

Posted by on January 17th, 2013

O-GlcNAc signalling during embryonic stem cell differentiation My lab is studying the signalling mechanisms governing the onset of differentiation of pluripotent embryonic stem (ES) cells. Work from this and other labs (e.g. 1, 2) has revealed a critical role for autocrine FGF signalling and consequent sustained phosphorylation of the kinase Erk during the differentiation process.[…]

Postdoctoral position – MRC Department of Biomedical/Developmental Genetics, University of Sheffield, UK

Posted by on October 26th, 2011

Overview The Research Associate will work in the MRC Centre for Developmental and Biomedical Genetics within the Department of Biomedical Science.  The department has an active community of researchers specialising in different aspects of developmental biology.  You will take part in a project aiming to understand how cell proliferation is temporally integrated with digit patterning[…]