One scientific story has dominated the news this week: the first report of CRISPR-edited human babies being born. The story’s scientific and ethical aspects stirred up heated debate, as did its means of delivery: rather than a published paper, the story broke with reports of clinical trial documents and then a YouTube video from lead researcher He Jiankui (from the Southern University of Science and Technology in Shenzhen), all on the eve of a conference he was due to speak at (and whose organisers were seemingly unaware what we was going to speak about).
In an associated Node post, we asked developmental and reproductive biologists to give their reaction to the story (and we’d love to hear yours too), but here we’ve collated a bunch of hopefully helpful links, and some recent Development commentaries on the issues surrounding gene editing in humans.
The story breaks
On 25 November, Antonio Regaldo in MIT Technology Review reported details of the study’s clinical trial data
The He Lab YouTube channel released this video on the same day (the channel also has four associated videos about the work)
“A surgery that could save a child from a lethal genetic disease like cystic fibrosis or from a life-threatening infection like HIV doesn’t just give that little boy or girl an equal chance at a healthy life. We heal a whole family”
He talks to the Associated Press (26/11)
Statement from He’s employer, the Southern University of Science and Technology, stating that the university knew nothing about He’s work and plans to set up an independent committee to investigate (in Chinese – translates page reads quite clearly; 26/11)
Reaction to the initial reports from Nature (26/11)
Ewan Birney, Director of EMBL-EBI, gives his thoughts on his blog (26/11)
Paul Knoepfler gives his response (26/11)
An OpEd by Eric Topol of the Scripps Research institute (27/11)
He talks at the Second International Summit on Human Genome Editing, 28th November
He’s talk begins at 1:18, and a Q&A moderated by Robin Lovell-Badge and Matthew Porteus starts at 1:39.
He’s presentation slides can be seen here:
A transcript of the talk made by Bryan Bishop
Reaction to the talk
Gaetan Burigo gave a helpful thread particularly regarding the science presented by He in the summit (28/11)
OK there are a lot to unravel in this He Jankui talk and panel discussion at the #GeneEditSummit on #CRISPR in human embryos leading to the birth of the twins Lulu and Nana. -> Let's analyze the science, the ethics and controversies -> thread pic.twitter.com/3qOCC6IhvJ
— Gaetan Burgio (@GaetanBurgio) November 28, 2018
Peter Mills, Assistant Director of the Nuffield Council on Bioethics, gives his thoughts (28/11)
Nature piece on reaction to the talk (28/11)
The Progress Educational Trust‘s Sarah Norcross gives her reaction (28/11)
George Church speaks to Science (28/11)
Statement by the Organizing Committee of the
Second International Summit on Human Genome Editing
Akshat Rathi helps make sense of how the story unfolded
Recent Development content
Here at Development we’ve been thinking about issues of human gene editing for some time, and have commissioned content specifically exploring scientific and ethical aspects. We recently published two Spotlight articles on the theme (published in 2017 and 2018 respectively, before the current story broke).
In Gene editing in human development: ethical concerns and practical applications, Janet Rossant summarizes some of the ethical considerations associated with the use of gene-editing techniques in human embryos and embryo-like entities, highlighting the need for open and informed debate.
This is obviously a fast moving story so if you have any links you think other readers would find useful, let us know!