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Genetics Unzipped – The future is now: Curing HIV, advancing CRISPR therapies, predatory phages for superbug infections

Posted by on November 7th, 2019

Exploring the latest advances in health technology such as CRISPR-based gene therapies, infection-fighting bacteriophage and a cure for HIV.

CRISPR-Cas9 – what’s left to know?

Posted by on August 8th, 2019

This post was originally posted on the MRC Weatherall Institute of Molecular Medicine’s blog Dominic Owens, PhD student in the De Bruijn group at MRC MHU, recounts how puzzling results and a fortuitous lab meeting uncovered unexpected outcomes of CRISPR editing and changed the direction of his research.   It’s May 2018 and I’m feeling nervous. I was[…]

CRISPR babies: a view from the centre of the storm

Posted by on February 8th, 2019

This article by Robin Lovell-Badge, published this week in Development, gives a front-row view of the CRISPR babies scandal from last year. When the story broke, we collated reactions from the field – be sure to check them out too.  Towards the end of November 2018, news broke that the Chinese researcher He Jiankui had[…]

The reported birth of CRISPR-edited humans: reactions from the field

Posted by on November 29th, 2018

One scientific story has dominated the news this week: the first report of CRISPR-edited human babies being born. In an associated Node post, we’ve collected the most useful links we could find surrounding the story, and here we reached out to members of the community for their perspectives. Some responses are hopefully still coming in[…]

The reported birth of CRISPR-edited humans: useful links

Posted by on November 29th, 2018

One scientific story has dominated the news this week: the first report of CRISPR-edited human babies being born. The story’s scientific and ethical aspects stirred up heated debate, as did its means of delivery: rather than a published paper, the story broke with reports of clinical trial documents and then a YouTube video from lead[…]

Senior Research Position (Boston, MA)

Posted by on June 27th, 2018

The DRSC/TRiP Functional Genomics Resources in the Perrimon group at Harvard Medical School in Boston, MA, USA, is seeking a highly motivated senior-level research technician to join our team. The successful candidate will be responsible for performing molecular biology, cell culture, protein purification, and/or related techniques as part of an overall research program focused on[…]

The Curious Case of Protocadherin 19 Epilepsy

Posted by on March 12th, 2018

Daniel Pederick & Paul Thomas Comment on our paper: Pederick, et al. 2018. Abnormal Cell Sorting Underlies the Unique X-Linked Inheritance of PCDH19 Epilepsy. Neuron 97 (1).   Here we discuss the curious case of female-restricted epilepsy, an unusual disorder caused by mutations in the Protocadherin 19 (PCDH19) gene. How changes in this cell adhesion[…]

The future of human reproduction: Stepping back from visions of Gattaca

Posted by on January 16th, 2018

The impact of developmental biology on society is particularly acute when it comes to reproduction – research informs efforts to assist reproduction and understand what happens when pregnancy goes wrong. Recent developments in stem cells, culturing conditions, gene editing and sequencing are also revealing aspects of human embryonic development previously hidden from us. Here at[…]

Addgene Resources to Grow Your Developmental Biology Toolkit

Posted by on November 8th, 2017

Addgene is a global, nonprofit repository that was created to help scientists share plasmids. Before we go over the developmental biology resources available at Addgene, here’s a little background on our organization. Our mission is to accelerate research and discovery by improving access to useful research materials and information. Labs deposit plasmids with Addgene at[…]

Research assistant in Development Biology, Sheffield University

Posted by on August 3rd, 2017

A Wellcome Trust/Royal Society funded Research Assistant position is available in Dr Kyra Campbell’s research group. This is a fantastic opportunity to join the Campbell group, who are focused on identifying the molecular mechanisms underlying epithelial cell plasticity during development and disease. We study how this fundamental property is orchestrated during morphogenesis of the Drosophila[…]