Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints.

The preprints this month are hosted on bioRxiv – use these links below to get to the section you want:

Developmental biology

• Patterning & signalling
• Morphogenesis & mechanics
• Genes & genomes
• Stem cells, regeneration & disease modelling
• Plant development
• Environment, evolution and development

Cell Biology

Modelling

Tools & Resources

Research practice and education

Developmental biology

| Patterning & signalling

Morphogen gradients applied basally to human embryonic stem cells to control and dissect tissue patterning
Tom Wyatt, Mingfeng Qiu, Julie Stoufflet, Hassan Omais, Gabriel Thon, Sara Bonavia, Pascal Hersen, Vincent Hakim, Benoit Sorre

Planar cell polarity aligns epithelial migration to coordinate tissue architecture and functional zonation
Rebecca F. Lee, Dami Oluwatade, Kaelyn Sumigray

Hippo signaling differentially regulates distal progenitor subpopulations and their transitional states to construct the mammalian lungs
Kuan Zhang, Madhuri Basak, Youssef Zaher, Erica Yao, Shao-An Wang, Thin Aung, Pao-Tien Chuang

Post-translational Tuning of Human Cortical Progenitor Neuronal Output
Julien Pigeon, Tamina Dietl, Myriame Abou Mrad, Ludovico Rizzuti, Miguel V. Silva, Natasha Danda, Corentine Marie, Clarisse Brunet Avalos, Hayat Mokrani, Laila El Khattabi, Alexandre D. Baffet, Diogo S. Castro, Carlos Parras, Boyan Bonev, Bassem A. Hassan

Temporal control of axonal floor plate crossing through a combination of incoherent feedforward and feedback loops of gene regulatory network regulating Robo3 expression
Reut Sudakevitz-Merzbach, Madhuri Majumder, Gerard Elberg, Marah Bakhtan, Dina Rekler, Sophie Khazanov, Benjamin J. Wheaton, Nissim Ben-Arie, Gilgi Friedlander, Chaya Kalcheim, Sara Ivy Wilson, Alexander Jaworski, Miri Adler, Avihu Klar

Cell-supracellular structural relations solve the French Flag Problem without graded molecular control
Clint S. Ko, Ruonan Chen, Nina T. Magid, Katharine Courtemanche, Pearson W. Miller, Alan R. Rodrigues, Amy E. Shyer

Axial Rotation Comprises Concurrent Twisting and Bending, Each Differentially Regulated by TGF-β Signaling
Yuki S. Kogure, Satoru Okuda, Kotaro Oka, Kohji Hotta

Mechanical control of histone serotonylation initiates neural crest migration in vivo
Joana E. Saraiva, Artemis G. Korovesi, Xiaoran Wei, Jaime A. Espina, Miguel Ribeiro, Ian Maze, Elias H. Barriga

Tbx genes influence early gene expression and photoreceptor patterning in the chick retina
Monika Ayten, Heer N.V. Joisher, Constance Cepko

Simplified In Vitro Generation of Human Gastruloids for Modelling Early Development
Takuya Azami, E. Elizabeth Patton, Jennifer Nichols

A human arteriovenous differentiation roadmap reveals vein developmental mechanisms and vascular effects of viruses
Lay Teng Ang, Sherry Li Zheng, Kevin J. Liu, Anastasiia Masaltseva, June Winters, Isabel von Creytz, Sawan K. Jha, Qingqing Yin, Crystal Qian, Xiaochen Xiong, Amir Dailamy, Ellie Xi, Juan C. Alcocer, Daniel W. Sorensen, Richard She, Karina Smolyar, Dorota Szumska, Svanhild Nornes, Renata M. Martin, Benjamin J. Lesch, Nicole K. Restrepo, Wenfei Sun, Jonathan S. Weissman, Heiko Lickert, Matthew P. Porteus, Mark A. Skylar-Scott, Christian Mosimann, Saulius Sumanas, Sarah De Val, Joseph B. Prescott, Kristy Red-Horse, Kyle M. Loh

Deciphering the Interaction Between Dvl2 and Profilin2: Effector Molecules of Non-Canonical Wnt Signaling
Saikat Das, Shubham Das, Sankar Maiti

Regulation of Hippo signaling by Atrophin in the developing Drosophila wing
Deimante Mikalauskaite, Cordelia Rauskolb, Tom Lehan, Srividya Venkatramanan, Lilia Carnes, Kenneth D. Irvine

Acvr2b receptors transduce all BMP signaling in the zebrafish gastrula and restrict Fibrodysplasia Ossificans Progressiva ACVR1-R206H signaling in a dose-dependent manner
Jeet H. Patel, Benjamin Tajer, Jira White, Finn Warrick, Mary C. Mullins

Differential usage of two, distinct DNA-binding domains regulates tissue-specific occupancy of the pioneer factor Zelda
Eliana F. Torres-Zelada, Hideyuki Komori, Hsiao-Yun Liu, Elizabeth D. Larson, Ally W.H. Yang, Zoe A. Fitzpatrick, Timothy R. Hughes, Christine A. Rushlow, Cheng-Yu Lee, Melissa M. Harrison

Dynamic and non-uniform expression of key transcription factors provides novel insights into the emergence of neural crest cells at the neural plate border
Andrew Montequin, Carole LaBonne

| Morphogenesis & mechanics

Motility-Driven Viscoelastic Control of Tissue Morphology in Presomitic Mesoderm
Sahil Islam, Mohd. Suhail Rizvi, Anupam Gupta

Tissue surface mechanics constrains proliferation-driven forces to guide mammalian body axis elongation
Marc Trani-Bustos, Ryan G Savill, Arthur Boutillon, Petr Pospíšil, Deniz Conkar, Claudia Froeb, Johannes R Soltwedel, Heidi L van de Wouw, Ellen M Sletten, Jesse V Veenvliet, Otger Campàs

Dorsal forerunner cells transmit epiboly forces to extend the zebrafish notochord
Christopher Small, Margot Kossmann Williams

Sulfatase modifying factors control the timing of zebrafish convergence and extension morphogenesis
Ailen Soledad Cervino, Amrita Basu, Ryan J. Weiss, Gursimran Kaur Bajwa, Rubén Marín Juez, Sandra Grimm, Cristian Coarfa, Margot Kossmann Williams

Tissue mechanics and systemic signaling safeguard epithelial tissue against spindle misorientation
Floris Bosveld, Baptiste Tesson, Eric van Leen, Sam Amirebrahimi, Raphael Thinat, Yohanns Bellaiche

Characterization of zebrafish nucleus pulposus in development and aging: A fish model for probing human intervertebral disc degeneration and regeneration
Jong-Su Park, Dhivyaa Rajasundaram, Diya Patel, Zachary W. Rachfal, Kyler Hoebe-Janssen, Brian R. Cabana, Katherine A. Davoli, Kira Lathrop, Gwendolyn A. Sowa, Nam V. Vo, Xiangyun Wei

MYRF is Essential for Epicardial Development
Elise V. Stanley, Chao Gao, Jason R. McCarthy, Maria I. Kontaridis, Tongbin Wu

Increased tissue tension caused by depletion of CLDN3 in the non-neural ectoderm causes neural fold fusion defects in chick embryos
Elizabeth-Ann Legere, Marie Dumont, Yojiro Yamanaka, Gabriel L. Galea, Aimee K. Ryan

Automated cell naming reveals reproducible and variable features of ascidian embryogenesis
Kilian Biasuz, Haydar Jammoul, Benjamin Gallean, Yanis Asloudj, Julien Laussu, Patrick Lemaire, Grégoire Malandain

Tetraploid Caenorhabditis elegans embryos exhibit enhanced tolerance to osmotic stress
Yuiko Oyama, Misako Ohama, Namu Yamada, Nozomi Suzuki, Kenji Kimura, Yuki Hara

CSF1R+ macrophage and osteoclast depletion impairs neural crest proliferation and craniofacial morphogenesis
Felix Ma, Rose Ru Jing Zhou, Matthew Rosin, Iris Zhou, Sabrina Ownsworth, Rouzbeh Ostadsharif Memar, Vincent B. Wong, Jessica M. Rosin

Induction of menstruation in mice reveals the regulation of menstrual shedding
Çağrı Çevrim, Nicholas J. Hilgert, Aellah M. Kaage, Andrew J.C. Russell, Allison E. Goldstein, Claire J. Ang, Jaina L.R. Gable, Laura E. Bagamery, Ana Breznik, Daniela J. Di Bella, Mustafa Talay, Jingyu Peng, Kathleen E. O’Neill, Fei Chen, Sean R. Eddy, Kara L. McKinley

Species-specific basal fluidization shapes early forebrain development
Shuting Xu, Guanlin Li, Michaela Wilsch-Bräuninger, Vikas Trivedi, Otger Campàs, Miki Ebisuya

Reciprocal E-cadherin signaling aligns apical surfaces between neighboring epithelial tissues to complete the C. elegans digestive tract
Lauren E. Cote, Maria D. Sallee, Rachel K. Ng, Melissa A. Pickett, Jérémy Magescas, Jessica L. Feldman

TWIST1 Modulates Cilia Length, Endocytic Vesicle Dynamics, and Cell-Cell Junctions during Neural Tube Morphogenesis
Derrick Thomas, Brittany M. Hufft-Martinez, Zarna Lalwani, Vi Pham, Mary Elmeniawi, An J. Tran, Jianming Xi, Irfan Saadi, Walid D. Fakhouri

Novel Tissue Mechanics-Guided Cellular Flows Enable the Evolution of Feather Follicles
Hans I-Chen Harn, Ting-Xin Jiang, Chih-Han Huang, Wen-Tau Juan, Tzu-Yu Liu, Tsao-Chi Chuang, Wan-Chi Liao, Yingxiao Wang, Ji Li, Cornelis J. Weijer, Ping Wu, Chin-Lin Guo, Cheng-Ming Chuong

A switch in collagen expression regulates cessation of distal tip cell migration in C. elegans
Victor Stolzenbach, Sophie S. Griffin, Priti Agarwal, Ronen Zaidel-Bar, Erin J. Cram

| Genes & genomes

Tuning Mitotic Recombination with Patterned DNA Nicks for Precision Mosaic Analysis
Yifan Shen, Ann T. Yeung, Bei Wang, Payton Ditchfield, Elizabeth Korn, Chun Han

Epigenomic landscape of the developing human rhombic lip reveals gene regulatory network and non-coding loci of developmental, evolutionary, and disease relevance
Xinghan Sun, Soumya Menon, Paul Wambo, Ilinca Lungu, Kimberly A. Aldinger, Shraddha Pai

TET1 non-catalytic activity shapes the chromatin landscape that directs de novo methylation establishment in the male germline
R.D. Prasasya, J. J. Kim, Z. Liu, R. M. Kohli, M. S. Bartolomei

Comprehensive Single Molecule View of Transcriptional Dynamics in Development
Thomas W. Tullius, Tohn Borjigin, Michael Levine

Loss of cell cycle gatekeeping by CNOT3 impairs hematopoietic stem and progenitor cell division and repopulating activity
Katie Yuen, Thilelli Taibi, Quang Anh Hoang, Marty Yue, Zongmin Liu, Effat Habibi, Elias Spiliotopoulos, Niveditha Ramkumar, Nick Nation, Glenn Edin, Thuy T. M. Ngo, Ly P. Vu

Sex-biased transcriptome in embryonic mouse cortices under Pax6 haploinsufficiency highlights Pbdc1 as a candidate regulator
Shyu Manabe, Shohei Ochi, Takako Kikkawa, Sharmin Naher, Mai Saeki, Kohdai Yamada, Hidetaka Kosako, Yusuke Kishi, Tatsuya Sawasaki, Noriko Osumi

DNA methylation profiles in diabetic embryos
Pu-Yu Li, Fu-Li Zhao, Yi-Juan Song, Bing-Yao Lei, Hao-Jin Niu, Ying-Fang Wang, Hong-Wei Jiang

Dynamic regulation of a domesticated DNA transposon-derived gene, in human germline and early embryonic development
Tanuja Bhardwaj, Sharmistha Majumdar

Induction of cellular totipotency by NACC1-driven feed-forward regulation
Thulaj Meharwade, Gilberto Duran-Bishop, Loïck Joumier, Sabin Dhakal, Mohammed Usama, Sanidhya Jagdish, Élie Lambert, Yacine Kherdjemil, François Robert, Mohan Malleshaiah

ALDH1L1 links folic acid and retinoic acid to prevent neural tube defects
Tamir Edri, Tali Abbou-Levy, Dor Cohen, José M. Inácio, Yehuda Shabtai, Graciela Pillemer, José António Belo, Abraham Fainsod

PEG10-ORF1 programs trophoblast progenitor development for placental labyrinth formation
Hirosuke Shiura, Mayuko Fujii, Masatoshi Ooga, Sayaka Wakayama, Daiyu Ito, Takashi Kohda, Tomoko Kaneko-Ishino, Fumitoshi Ishino

The transcription factor Osr1 regulates epithelial-mesenchymal crosstalk during embryonic bladder development
V Murugapoopathy, IR Gupta

A novel role for the CNTN6 locus in lumenization and radial glial cell fate determination during early human cortical development revealed in cerebral organoids
T.A. Shnaider, A.M. Yunusova, S.A. Yakovleva, A.S. Knyazeva, I.E. Pristyazhnuk, P.S. Belokopytova, A.A. Khabarova, A.S. Ryzhkova, V.S. Fishman, T.V. Nikitina, I.N. Lebedev, V.S. Tarabykin, A.V. Smirnov, O.L. Serov

Dynamic landscapes of gene regulatory networks in early mammalian neurogenesis: Insights into brain evolution and disorder risk
Kalpana Hanthanan Arachchilage, Ryan D. Risgaard, Jie Sheng, Pubudu Kumarage, Jerome J. Choi, Sayali Anil Alatkar, Chirag Gupta, Xinyu Zhao, André M. M. Sousa, Daifeng Wang

METTL3 Uncouples Chromatin Accessibility from Transcription during Retinal Development
Jing Xu, Yuanhao Huang, Zhaowei Han, Qiang Li, Jie Liu, Rajesh C. Rao

| Stem cells, regeneration & disease modelling

Human pancreatic organoids derived from pluripotent stem cells recapitulate pancreatic organogenesis
Jonathan A. Brassard, Patrizia Tornabene, Daniel O. Kechele, Lily Deng, Julie B. Sneddon, Mansa Krishnamurthy, James M. Wells

Androgen receptor imprints satellite cells stemness and preserves their reservoir for lifelong regeneration and optimal repair
Joe G. Rizk, Kamar C. Ghaibour, Sirine Souali-Crespo, Aurore Bilger, Emilia Calvano, Hugues Jacobs, Nadia Messaddeq, Qingshuang Cai, Erwan Grandgirard, Rajesh Sahu, Arnaud Ferry, Gianni Zanardelli, Nacho Molina, Coralie Fontaine, Jean-François Arnal, Daniel Metzger, Delphine Duteil

Generation and validation of an aryl hydrocarbon receptor knockout human embryonic stem cell line
Noa Gang, Cuilan Nian, Ekaterina Filatov, Dahai Zhang, Myriam P. Hoyeck, Bailey Laforest, Francis C. Lynn, Jennifer E. Bruin

Low oxygen promotes extravillous trophoblast progenitor expansion but restrains maturation
Gina L. McNeill, Giada Guntri, Ida Calvi, Alastair H. Kyle, Hans-Rudolf Hotz, Victoria M. Leonard, Willie Wu, Matthew J. Shannon, Andrew I. Minchinton, Keegan Korthauer, Margherita Y. Turco, Alexander G. Beristain

Combined Metabolic and Viral Insults in Pregnancy Disrupt Specific Placental Nutrient Transporter Systems in Mice
Thaina Ferraz, Lucas Cardoso, Sadra Mohammadkhani, Enrrico Bloise, Kristin Connor

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair
Sirine Souali-Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil

Gsx2 Regulates Oligodendrocyte Precursor Formation in the Zebrafish Spinal Cord
Kimberly Arena, Christina A. Kearns, Mohamoud Ahmed, Rebecca O’Rourke, Charles Sagerstrom, Santos Franco, Bruce Appel

NanoCT-confocal mapping of mouse ovaries reveals lifespan-persistent symmetric organizational rules of primary-to-preovulatory follicles
Giulia Fiorentino, Andrea Fantinato, Annapaola Parrilli, Tommaso Marzi, Cesare Alippi, Riccardo Bellazzi, Laura Rienzi, Filippo Maria Ubaldi, Alberto Vaiarelli, Valeria Merico, Paola Rebuzzini, Danilo Cimadomo, Silvia Garagna, Maurizio Zuccotti

Domain-specific mechanisms of YAP1 variants in ocular coloboma revealed by in-vitro and organoid studies
Srishti Silvano, Annika Rick-Lenze, James Bagnall, Mrinalini Saravanakumar, Xinyu Yang, Robert Lea, Lindsay Birchall, Julie R. Jones, Jessica M. Davis, Anzy Miller, Rachel E. Jennings, Elliot Stolerman, Jamie M. Ellingford, Simon C. Lovell, Forbes Manson, Gavin Arno, Panagiotis I. Sergouniotis, Cerys S. Manning

Buffering of genetic defects in animal development by regeneration programs
Kazunori Ando, Sushant Bangru, John Welsby, John D. Thompson, Kenneth D. Poss

Failure of DNA repair leads to the tumorigenic transformation of a regenerating blastema in Drosophila imaginal discs
Tanroop Kaur, Ada Repiso, Ying Liu, Paula Doria, Joan Urgell, Luis Rodriguez-Escudero, Katerina Karkali, Yanhui Hu, Norbert Perrimon, Enrique Martin-Blanco

Trophoblast stem cells and syncytiotrophoblasts lack inflammatory responses to LPS but retain robust interferon-mediated antiviral immunity
Cristine R. Camp, Joshua Baskaran, Matthew Brown, Carly Parker, Paige Drotos, Rachel C. West

Pax6 maintains lens epithelial cell identity and coordinates secondary fiber cell differentiation
Barbora Antosova, Jana Smolikova, Anna Zitova, Jitka Lachova, Zbynek Kozmik

Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
Giulia L. M. Boezio, Jasper R. L. Depotter, Thomas J. R. Frith, Arthur Radley, Stephanie Strohbuecker, Ana C. Cunha, Michael Howell, James Briscoe

PIWIL3-piRNA Pathway Is Essential for Rabbit Oogenesis and Embryogenesis via Broad Regulation of the Transcriptome and Proteome
Yuanyuan Gong, Ling Li, Yuqiang Qian, Ting Lu, Zhaoran Zhang, Lichun Jiang, Guohui Liu, Meihua Cui, Shangang Li, Zhanjun Li, Shuo Shi, Haifan Lin

Maternal High Fat Diet and Acute Viral Mimic Exposure Impact Placental Inflammation, Lipid Peroxidation, and Cellular Dynamics Across Mouse Pregnancy
Thaina Ferraz, Lucas Cardoso, Sadra Mohammadkhani, Enrrico Bloise, Kristin L. Connor

A model of apical-out human first trimester trophoblast organoids to study regeneration after syncytial damage
Ida Calvi, Giada Guntri, Alexandra Graff Meyer, Lhéanna Klaeylé, Qian Li, Jan Seebacher, Hans-Rudolf Hotz, Naomi McGovern, Margherita Y. Turco

Lipid Metabolism Remodeling in Human Cardiomyocyte Differentiation and Maturation
Haite Tang, Raina Liu, Zhiqiang Xiong, Qiqi He, Gang Lu, Wai-Yee Chan, Wuming Wang

Dynamic Spiral Artery Remodeling in Early Human Pregnancy: An Analysis of Specimens Collected with a Standardized Protocol
Shenglong Ye, Yeling Ma, Wenlong Li, Linjing Qi, Xiao Fang, Xin Yu, Duo Yu, Xiaoye Wang, Dong-bao Chen, Yan-Ling Wang

Human organoids reveal PTEN-driven mesendoderm specification via retinoic acid signaling suppression
Wuming Wang, Qiqi He, Hong Zhang, See-Wing Chan, Zhiqiang Xiong, Haite Tang, Yue Lv, Xianwei Su, Ya Guo, Yong Fan, Xingguo Liu, Xiuwu Bian, Andrew M. Chan, Hongbin Liu, Gang Lu, Wai-Yee Chan

Uterine stromal Erbb3-Igf1 signaling is critical to functional gland development conducive to implantation
Bo Li, Mengyuan Wang, Amanda Dewar, Wenbo Deng, Sudhansu K. Dey, Xiaofei Sun

Single-cell transcriptomic profiling of bam mutant tumor reveals germline heterogeneity and gcrf1 as a modulator in Drosophila germ cells
Zhipeng Sun, Yujun Zeng, Todd G. Nystul, Guohua Zhong

Transient let-7/miR-98 reprograms primed pluripotency to induce naive human PSCs
Yoshihiko Fujita, Moe Hirosawa, Karin Hayashi, Hiroki Ono, Belinda Kaswandy, Mai Ueda, Maya Lopez, Takuya Yamamoto, Yasuhiro Takashima, Hirohide Saito

Flexible oocyte manipulation with delayed maturation and improved SCNT efficiency using induced pluripotent stem cells
Luis H. de Aguiar, Yoke Lee Lee, Abdallah W. Abdelhady, Prasanthi Koganti, Vimal Selvaraj, Soon Hon Cheong

In Vitro Fertilization Accelerates Female Reproductive Aging Through Early Ovarian Failure
Eric A. Rhon-Calderon, Cassidy N. Hemphill, Alexandra J. Savage, Ana Domingo-Muelas, Zhengfeng Liu, Christopher J. Krapp, Laren Riesche, Nicolas D. Plachta, Richard M. Schultz, Marisa S. Bartolomei

Dysregulated circRNA expression profile and associated miRNA sponging in abnormal lung development in congenital diaphragmatic hernia
Marietta Jank, Arzu Ozturk Aptekmann, Muntahi Mourin, Nolan De Leon, Matthew Kraljevic, Daywin Patel, Wai Hei Tse, Claire McCallum, Richard Wagner, Shana Kahnamoui, Yuichiro Miyake, Athanasios Zovoilis, Michael Boettcher, Richard LeDuc, Richard Keijzer

IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures
Todd W. Dowrey, Samuel F. Cranston, Nicholas Skvir, Yvonne Lok, Payton Bock, Elizabeth K. Kharitonova, Elise MacDonald, Ella Zeldich, Christopher Gabel, Alexander Tyshkovskiy, Stefano Monti, Vadim N. Gladyshev, Paola Sebastiani, Thomas T. Perls, Stacy L. Andersen, George J. Murphy

PPARG directs trophoblast cell fate and establishment of the uterine-placental interface
Esteban M. Dominguez, Ayelen Moreno-Irusta, Khursheed Iqbal, Keting Chen, Alex Finlinson, Marc Parrish, Hiroaki Okae, Takahiro Arima, Geetu Tuteja, Michael J. Soares

Cfap300 regulates the transdifferentiation of Corpuscle of Stannius cells in zebrafish
Usharani Nayak, Kalyani Sahoo, Praveen Barrodia, Rajeeb K. Swain

Basal cytoplasmic calcium levels regulate C. elegans germ stem cell proliferation
Alexandra C. Wells, Parva M. Vyas, Aahana N. Shankaran, Corrissa J. Velder, Rabia N. Kaya, Edward T. Kipreos

Regeneration of distinct complex structures in the annelid Platynereis is partially based on common morphological, cellular, and molecular events
Zoé Velasquillo Ramirez, Viktor Starunov, Louis Paré, Loeiza Baduel, Théaud Hezez, Sophie Lemoine, Catherine Senamaud-Beauford, Michel Vervoort, Morgane Thomas-Chollier, Nikos Konstantinides, Eve Gazave

Impaired subgranular zone radial glia morphology and transient amplification of neural progenitors in Mllt11-deficient mice leads to increased hippocampal neurogenesis
Sam Moore, Danielle Stanton-Turcotte, Karolynn Hsu, Emily A. Witt, Angelo Iulianella

Lineage Tracing Reveals a Shared Cellular Origin for Supraclavicular Brown and Inguinal Beige Adipocytes
Yali Ran, Kai Zhang, Yi-Ting Shen, Qianxing Mo, Ziyi Wang, Hari Krishna Yalamanchili, Sharon John, Mari Kogiso, Xia Gao, Chunmei Wang, Tanvi Sinha, Brian L. Black, Miao-Hsueh Chen

ETV2 mediated differentiation of human pluripotent stem cells results in functional endothelial cells for engineering advanced vascularized microphysiological models
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm

Human iPSC-derived salivary gland organoids model diabetic salivary gland dysfunction
Devon Duron Ehnes, Akira Morishita, Ashish Phal, Hee Yun Jung, Yen Chian Lim, Zachary Foreman, Vincenzo Cirulli, Julie Mathieu, Hannele Ruohola-Baker

| Plant development

Maternal transmission of a plastid structure enhances offspring fitness
Tyler J. Carrier, Andrés Rufino-Navarro, Thorben Knoop, Urska Repnik, Andrés Mauricio Caraballo-Rodríguez, David M. Needham, Corinna Bang, Sören Franzenburg, Marc Bramkamp, Willi Rath, Arne Biastoch, José Carlos Hernández, Ute Hentschel

Rice Ethylene Receptors Function as Ca²⁺-Permeable Ion Channels to Orchestrate Calcium-Dependent Antagonism of Ethylene Responses in Roots
Zhangli Ye, Zijian Yang, Changyuan Li, Yangbo Chen, Enjie Yu, Chunhui Song, Zongran Yang, Shuo Liu, Hao Tian, Dongdong Kong, Legong Li, Liangyu Liu

Primary metabolism underpins the execution of immune responses in different tissues of the same plant
Emma C. Raven, Rhea Stringer, Catherine Walker, Hannah Rae Thomas, Christine Faulkner

Assembly of two functionally-distinct protein import complexes in the outer membrane of plant chloroplasts
Sreedhar Nellaepalli, Domagoj Baretic, Astrid F. Brandner, Sybille Kubis-Waller, Ziad Soufi, Shuyang Cheng, Sireesha Kodru, Jun Fang, Ursula Flores-Perez, Vaishnavi Ravikumar, Pablo Pulido, Marjorie Fournier, Ivan Ahel, Syma Khalid, R. Paul Jarvis

| Environment, evolution and development

Sensory receptor expansion and neural accommodation in butterfly color vision
Ke Gao, Julia Ainsworth, Antoine Donati, Yunchong Zhao, Michelle Franc Ragsac, Cara Genduso, Zoie Andre, Andrew Tomlinson, Michael W. Perry

Two Cytochrome P450 epoxidases mediate juvenile hormone biosynthesis in Drosophila melanogaster
Daiki Fujinaga, Yuya Ohhara, Naoki Okamoto, et al.

Endothelin 3 and T-type Ca²⁺ channels drive enteric neural crest cell calcium activity, contractility and migration
Nicolas R. Chevalier, Fanny Gayda, Nadège Bondurand, et al.

Loss of the distal-proximal GLP-1/Notch activation gradient in the aging C. elegans germline
Rustelle Janse van Vuuren, Pier-Olivier Martel, Patrick Narbonne

Apoptosis promotes fertility in C. elegans by maintaining functional germline morphology
UN Saydee-Onwubiko, ME Werner, GC Trapp, AS Maddox

Trehalose metabolism regulates transcriptional control of muscle development in lepidopteran insects
Sharada Mohite, Tanaji Devkate, Prashant Kalaskar, Prashant Singh, Abhishek Subramanian, Rakesh Shamsunder Joshi

fgf8a signalling shapes brain divergence between Malawi cichlids
Aleksandra Marconi, Jake Morris, Pío Sierra, Dillan Saunders, Joel Elkin, Benjamin Steventon, Richard Durbin, Stephen H. Montgomery, M. Emília Santos

Circulating hemocytes continue to proliferate throughout lifespan in Daphnia
S.C. Cuthrell, L. Y. Yampolsky

Cell Biology

Kv2.1-Kv6.4 subunits deficiency impairs inhibitory signaling and visual circuit dynamics in zebrafish
Ruchi P. Jain, Rosa R. Amini, Lukasz Majewski, Vladimir Korzh

Multiplexed embryo profiling links cellular state to zygotic genome activation in single cells
Max Hess, Marvin F. Wyss, Edlyn Wu, Joel Lüthi, Chiara Rebagliati, Nadine L. Vastenhouw, Darren Gilmour, Shayan Shamipour, Lucas Pelkmans

Lymphatics unload VEGFR3 in response to the endothelial stress upon VEGFR2 insufficiency
Taotao Li, Xudong Cao, Fei Zhou, Xiujuan Li, Wenjuan Ma, Haoyu Zhong, Beibei Xu, Man Chu, Xiwen Jia, Kai Ding, Xin Shen, Yahui Liu, Yun Zhao, Zhen Zhang, Junhao Hu, Young-Kwon Hong, Lena Claesson-Welsh, Yulong He

Clinical Interventions and Inflammatory Signaling Shape the Transcriptional and Cellular Architecture of the Early Postnatal Lung
Tristan Frum, Angeline Wu, Marcela S. Ymayo, Yu-Hwai Tsai, Sha Huang, Mengkun Yang, Sydney G. Clark, Peggy P. Hsu, Ian A. Glass, Gail H. Deutsch, Jason R. Spence

Trophoblast stem cells and syncytiotrophoblasts lack inflammatory responses to LPS but retain robust interferon-mediated antiviral immunity
Cristine R. Camp, Joshua Baskaran, Matthew Brown, et al.

Direct comparison of constitutive Rax-Cre transgenic drivers that activate in the mouse embryonic eye field
Nadean L. Brown, Samuel Goodyear-Brown, Sabine Fuhrmann

ABCC6 and ANK regulate extracellular homeostasis of pyrophosphate and citrate and affect mineral deposition in bones and soft connective tissues
Flora Szeri, Fatemeh Niaziorimi, Celina Ng, Cassandra Mikkelson, Ibtesam Rajpar, Qinglin Wu, Steven P. Matyus, Margery A. Connelly, George Tavadze, Stefan Lundkvist, Ryan E. Tomlinson, Koen van de Wetering

Hemidesmosomes regulate epidermal differentiation during embryogenesis
Juliet S. King, Kendall J. Lough, Scott E. Williams

Fluid-Niche and Microglial Signatures Prime Robust Intraventricular Macrophage Response to Blood During Brain Development
Miriam E. Zawadzki, Christine Hehnly, Jordan C. Benson, Dario X. Figueroa Velez, Sivan Gelb, Ceva Stanley, Lillian I.J. Byer, Huixin Xu, Cameron Sadegh, Aja Pragana, Maria K. Lehtinen

Nuclear lamina-associated domain biogenesis is regulated by nuclear pore density during embryogenesis and mediates UV protection
Fei Xu, Adrián Fragoso-Luna, Itai Sharon, Angelo L. Angonezi, Ohad Medalia, Peter Askjaer, Susan E. Mango

Modelling

Excitatory neurons as the default fate in bifurcation of excitatory and inhibitory neuron lineages
Mei Wang, Xiao-Ying Qiu, Yun-Bin Duan, Xia Tang, Qi Lu, Yan Li, Hui-Wen Qin, Xing-Tao Long, Meng-Meng Jin, Peng-Yu Fan, Hui Zhang, Ya-Nan Li, Jie He

Integrative Functional Genomics Identifies ARHGAP10 in the 4q31.2 Locus as a Novel Congenital Heart Disease and Ciliopathy Gene
Ewelina Sochaka, Svanna Hinson, Dave Shook, Doug DeSimone, Saurabh Kulkarni

Rapid canalization of chromosome conformation-transcription fingerprints during embryogenesis revealed by fully-automated cell identity decoding with CeSCALE
Konstantinos Ntemos, Fei Xu, Nour-Zaynab Bazzi, Geoffrey Fucile, Hermina Petric Maretic, Ivan Dokmanic, Susan E. Mango, Ahilya N. Sawh

A Single-cell Spatiotemporal Manifold of Tissue Morphology and Dynamics
Erin Haus, Anthony Santella, Yichi Xu, Ruohan Ren, Dali Wang, Zhirong Bao

Stochastic Modeling of BMP Heterodimer-Receptor Interactions Shows Emergence of Low-Pass Filtering Behavior
Nissa J. Larson, Aasakiran Madamanchi, Linlin Li, David M. Umulis

A conserved logic for the development of cortical layering in tetrapods
Astrid Deryckere, Saket Choudhary, Connor Lynch, Lian Kirit V. P. Limperis, Pauline Affatato, Jamie Woych, Elias Gumnit, Alonso Ortega Gurrola, Rahul Satija, Christian Mayer, Maria Antonietta Tosches

Tools & Resources

Jam2 Signaling Functions Downstream of Hand2 To Initiate The Formation Of Organ-Specific Vascular Progenitors In Zebrafish
Martyna Griciunaite, Julius Martinkus, Sanjeeva Metikala, Ricardo DeMoya, Suman Gurung, Diandra Rufin Florat, Saulius Sumanas

A toolkit for testing membrane-localising tags across species
Irene Karapidaki, Mette Handberg-Thorsager, Tsuyoshi Momose, Hitoyoshi Yasuo, Grigory Genikhovich, Sarah Assaf, Clara Deleau, Ying Pang, Clayton Pavlich, Beke Lohmann, Maria Lorenza Rusciano, Mattia Stranges, Juliette Mathieu, Marie Zilliox, Kirill Ustyantsev, Bastien Salmon, Béryl Laplace-Builhé, Manon Koenig, Jeffrey J. Colgren, Maria Ina Arnone, Eugene Berezikov, Thibaut Brunet, Gregor Bucher, Pawel Burkhardt, Daniel J. Dickinson, Evelyn Houliston, Jan Huisken, Lucas Leclère, Michalis Averof

The SPN-4 Rbfox RNA-binding protein selects maternal mRNAs for CCR4-NOT-dependent clearance in early Caenorhabditis elegans embryos
Caroline A. Spike, Dylan M. Parker, Tatsuya Tsukamoto, Naly Torres-Mangual, Erika C. Tsukamoto, Karissa Coleman, Micah D. Gearhart, David Greenstein, Erin Osborne Nishimura

Dissecting Small Noncoding RNA Landscapes in Mouse Preimplantation Embryos and Human Blastoids for Modeling Early Human Embryogenesis
Savana Biondic, Zhao Cheng, Richard Yin, Thorold Theunissen, Sophie Petropoulos

Generation of parasympathetic neurons from hiPSC that reproduce the electrophysiological properties of native neurons and modulate the activity of hiPSC-atrial cardiomyocytes
Alison M. Thomas, Isabella Noelle Chiong, Joana F Neves, Andrew Tinker, Franziska Denk,  Laura Fedele

TUSC3 serves as a rate-limiting gatekeeper of a glycan-mediated ER Triage Checkpoint for BMP4/Dpp
Antonio Galeone, Emilio Solazzo, Francesco Lavezzari, Seung-Yeop Han, Bruna My, Riccardo Rizzo, Giuseppe Gigli, Hamed Jafar-Nejad, Thomas Vaccari

A regulatory region that controls Wnt gene expression following tissue injury is required for proper muscle regeneration
Catriona Y. Logan, Xinhong Lim, Matt Fish, Makiko Mizutani, Brooke Swain, Roel Nusse

Research practice & education

The W-index: a novel tool to evaluate gender equity in STEM research
Penelope Holland, Jalene M. LaMontagne, V. Bala Chaudhary, Suw Charman-Anderson, Lindsey Gillson, Thorunn Helgason, Angela Lipscomb, Elva J. H. Robinson, Alex James

Systematic Review of Over A Century of Global Bioscience Research
Okechukwu Kalu Iroha, Dauda Wadzani Palnam, Peter Abraham, Israel Ogwuche Ogra, Ndukwe K. Johnson, Elkanah Glen, Dasoem Naanswan Joseph, Seun Cecilia Joshua, Grace Peter Wabba, Morumda Daji, Dogara Elisha Tumba, Mercy Nathaniel, Emohchonne Utos Jonathan, Samson Usman, Mela Ilu Luka, Vaibhav B. Sabale, Emmanuel Oluwadare Balogun, Umezuruike Linus Opara

New Quantitative Cost-Impact Effectiveness Indexes to Assist in Publication Decisions by Researchers in the Open Access Era
Julia C. Hardy, Christine Kim Vu, Dong Wang

Enhancing CRISPR Education: A Plug-And-Play Framework for Teaching Gene Editing in Plant Biology
Divya Jain, Faizan Ali, Gift Obunkukwu, Hyndavi Yammanuru, Jing Zou, Joshua Obeng, Kyla Danae Hughes, Laxmi Joshi, Madhavarapu Sudhakar, Oluwaseun Adeyemi, Peter Prestwich, Shahla Borzouei, Shivani Dharam, Shubh Pravat Singh Yadav, Mst Sumayae Khan, Rajni Parmar, Upama Adhikari, Ali Taheri, Robin Taylor, Vicki Caruana, Mary Williams, Sonali Roy

How to catch flies in the city (fast): Citizen Science on Drosophila ecology helps to raise awareness for biodiversity in urban environments
Isolde Gottwald, Sonja Steindl, Flora Strasser, Megumi Kiesel, Heimo Rainer, Elisabeth Haring, Martin Kapun

Evaluating peer-to-peer bioinformatics education: a case study of student learning outcomes and community impact in an undergraduate multi-omic data analysis course
Wade R. Boohar, Kayla Y. Xu, Nicole Black, Mahija Mogalipuvvu, Kate Manley, Peter Calabrese, Jerry S.H. Lee

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