Our latest monthly trawl for developmental biology (and other cool) preprints. See last year’s introductory post for background, and let us know if we missed anything

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It all went very meta this month with Matthew Cobb’s PeerJ preprint about a forgotten experiment in preprints from the 1960s. The story was highlighted in Science, a journal, Cobb explains, whose editor disparaged the initial preprint experiment in the 60s. Elsewhere, doubts were raised about last month’s headline-making human embryo CRISPR paper, as highlighted on the Niche (which also highlighted Shoukhrat Mitalipov’s response to the prepint).

And I have to share the start to an abstract from Javier Quilez and colleagues’ preprint on what makes large sequencing projects successful:

 

“T47D_rep2 and b1913e6c1_51720e9cf were two Hi-C samples. They were born and processed at the same time, yet their fates were very different. The life of b1913e6c1_51720e9cf was simple and fruitful, while that of T47D_rep2 was full of accidents and sorrow…”

 

The preprints were hosted on bioRxiv, PeerJ  and arXiv. Use these links to get to the section you want:

 

Developmental biology

| Patterning & signalling

| Morphogenesis & mechanics

| Genes & genomes

| Stem cells, regeneration & disease modelling

Evo-devo & evo

Cell biology

Modelling

Tools & resources

| Imaging etc.

| Genome tools

Research practice

Why not…

 

Developmental biology

| Patterning & signalling

Drosophila neural stem cells are polarized by their daughter cells. Nicolas Loyer, Jens Januschke

 

 

Generation, selection and transcriptomic profiling of human neuromesodermal and spinal cord progenitors in vitro. Laure Verrier, Lindsay Davidson, Marek Gierliński, Kate G. Storey

 

 

A population of adult satellite-like cells in Drosophila is maintained through a switch in RNA-isoforms. Hadi Boukhatmi, Sarah Bray

 

Programming of neural progenitors of the adult subependymal zone towards a glutamatergic identity by neurogenin2. Sophie Peron, Leo M. Miyakoshi, Monika S. Brill, Felipe Ortega, Marisa Karow, Sergio Gascon, Benedikt Berninger

 

The effect of Wnt signaling on the localization, molecular size and activity of the beta-catenin destruction complex in vivo. Kristina Schaefer, Shiping Zhang, Teresa Bonello, Clara Williams, Daniel McKay, Mark Peifer

 

The BMP2/4 ortholog Dpp functions as an inter-organ signal that regulates developmental timing in Drosophila. Linda Setiawan, Alexis L Woods, Iswar K Hariharan

 

The effect of sonic hedgehog on motor neuron positioning in the spinal cord during chicken embryo development. Ciqing Yang, Xiaoying Li, Qiuling Li, Qiong Li, Han Li, Bichao Zhang, Juntang Lin

 

ShhN-mediated activation of Smo in the absence of Ptch1/2 function. Catalina Casillas, Henk Roelink

 

Copb2 Is Essential For Embryogenesis And Hypomorphic Mutations Cause Human Microcephaly. Andrew DiStasio, Ashley Driver, Kristen Sund, Milene Donlin, Ranjith M. Muraleedharan, Shabnam Pooya, Beth Kline-Fath, Kenneth Kaufman, Cynthia Prows, Elizabeth Schorry, Biplab DasGupta, Rolf Stottmann

 

Ttc21b is required in Bergmann glia during postnatal cerebellar development. Ashley M. Driver, Christopher Shumrick, Rolf Stottmann

 

 

Protein phosphatase V ensures timely cell cycle remodeling during the mid-blastula transition in Drosophila. Boyang Liu, Hung-wei Sung, Ingo Gregor, Arno Müller, Joerg Grosshans

 

UNC-5 (UNC5) mediates neuronal outgrowth patterning in Caenorhabditis elegans by regulating UNC-40 (DCC) asymmetric localization. Gerard Limerick, Xia Tang, Won Suk Lee, Ahmed Mohamed, Aseel Al-Aamiri, William G. Wadsworth

 

Cdx4 regulates the onset of spinal cord neurogenesis. Piyush Joshi, Andrew J. Darr, Isaac Skromne

 

 

Minor spliceosome inactivation in the developing mouse cortex causes self-amplifying radial glial cell death and microcephaly. Marybeth Baumgartner, Anouk M. Olthof, Katery C. Hyatt, Christopher Lemoine, Kyle Drake, Nikita Sturrock, Nhut Nguyen, Sahar Al Seesi, Rahul N. Kanadia

 

PI3K regulates intraepithelial cell positioning through Rho GTP-ases in the developing neural tube. Blanca Torroba, Antonio Herrera, Anghara Menendez, Sebastian Pons

 

Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development. Xiaomin Su, Chenglei Wu, Xiaoying Ye, Ming Zeng, Zhujun Zhang, Yongzhe Che, Yuan Zhang, Lin Liu, Yushuang Lin, Rongcun Yang

 

Time-resolved Interaction Proteomics of the Putative Scaffold Protein GIGANTEA in Arabidopsis thaliana. Johanna Krahmer, Greg Goralogia, Akane Kubota, Richard S. Johnson, Young Hun Song, Karen Halliday, Michael J. MacCoss, Thierry LeBihan, Takato Imaizumi, Andrew Millar

 

 

Cpk2, a catalytic subunit of cyclic AMP-PKA, regulates growth and pathogenesis in rice blast. Poonguzhali Selvaraj, Qing Shen, Yang Fan, Naweed I. Naqvi

 

 

| Morphogenesis & mechanics

Live imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesis. Kenzo Ivanovitch, Susana Temino, Miguel Torres

 

Modelling Volvox epithelial folding, from Haas, et al.’s preprint

 

Mechanics and Variability of Cell Sheet Folding in the Embryonic Inversion of Volvox. Pierre A. Haas, Stephanie S.M.H. Höhn, Aurelia R. Honerkamp-Smith, Julius B. Kirkegaard, Raymond E. Goldstein

 

 

Pan-embryo cell dynamics of germlayer formation in zebrafish. Gopi Shah, Konstantin Thierbach, Benjamin Schmid, Anna Reade, Ingo Roeder, Nico Scherf, Jan Huisken

 

Asymmetric cell volume changes regulate epithelial morphogenesis in zebrafish Kupffer’s vesicle. Agnik Dasgupta, Matthias Merkel, Andrew E. Jacob, Jonathan Edward Dawson, Jeffrey D. Amack, Lisa Manning

 

Decoupling the roles of cell shape and mechanical stress in orienting and cueing epithelial mitosis.Alexander Nestor-Bergmann, Georgina A Stooke-Vaughan, Georgina K Goddard, Tobias Starborg, liver E Jensen, Sarah Woolner

 

Bimodal Spindle Orientation Drives Tissue Regularity in a Proliferating Epithelium. Tara M. Finegan,Daxiang Na, Austin V. Skeeters, Nicole S. Dawney,Patrick W. Oakes, Alexander Fletcher, Dan T. Bergstralh

 

 

 

The actin cytoskeleton governs apical mitosis and daughter cell dispersion in intestinal epithelia. Kara L. McKinley, Nico Stuurman, Ophir D. Klein, Ron D. Vale

 

 

Anisotropic Cellular Mechanoresponse for Radial Size Maintenance of Developing Epithelial Tubes. Tsuyoshi Hirashima, Taiji Adachi

 

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development. Filipa Neto, Alexandra Klaus-Bergmann, Yu-Ting Ong, Silvanus Alt, Anne-Clemence Vion, Anna Szymborska, Joana R. Carvalho, Irene Hollfinger, Eireen Bartels-Klein, Claudio A. Franco, Michael Potente, Holger Gerhardt

 

Neurexin and Neuroligin-based adhesion complexes drive axonal arborisation growth independent of synaptic activity. William D. Constance, Amrita Mukherjee, Yvette E. Fisher, Sinziana Pop, Eric Blanc, Yusuke Toyama, Darren W. Williams

 

The RacGAP βChimaerin is essential for cerebellar granule cell migration. Jason A. Estep, Wenny Wong, Yiu-Cheung E. Wong, Brian M. Loui, Martin M. Riccomagno

 

Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus. Francois M. Lambert, Laura Cardoit, Elric Courty, Marion Bougerol, Muriel Thoby-Brisson, John Simmers, Hervé Tostivint, Didier Le Ray

 

 

Chick cranial neural crest cells migrate by progressively refining the polarity of their protrusions. Miriam A Genuth, Christopher DC Allen, Takashi Mikawa, Orion Weiner

 

Distinct effects of tubulin isotype mutations on neurite growth in Caenorhabditis elegans. Chaogu Zheng, Margarete Diaz-Cuadros, Ken Nguyen, David H. Hall, Martin Chalfie

 

Clearance of senescent decidual cells by uterine natural killer cells drives endometrial remodeling during the window of implantation. Paul J. Brighton, Yojiro Maruyama, Katherine Fishwick, Pavle Vrljicak, Shreeya Tewary, Risa Fujihara, Joanne Muter, Emma S. Lucas, Taihei Yamada, Laura Woods, Raffaella Lucciola, Yie Hou Lee, Satoru Takeda, Sascha Ott, Myriam Hemberger, Siobhan Quenby, Jan J. Brosens

 

Flavonol rhamnosylation indirectly modifies the cell wall defects of RHAMNOSE BIOSYNTHESIS1 mutants by altering rhamnose flux. Adam Saffer, Vivian Irish

 

Dlic1 deletion impaired cerebellar development in mouse. Shanshan Kong, Wufan Tao

 

 

| Genes & genomes

Local and global chromatin interactions are altered by large genomic deletions associated with human brain development. Ying Zhang, Xianglong Zhang, Xiaowei Zhu, Carolin Purmann, Michael Haney, Thomas Ward, Jie Yao, Sherman Weissman, Alexander Urban

 

Nonparametric Bayesian inference of transcriptional branching and recombination identifies regulators of early human germ cell development. Christopher Andrew Penfold, Anastasiya Sybirna, John Reid, Yun Huang, Lorenz Wernisch, Zoubin Ghahramani, Murray Grant, M. Azim Surani

 

Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells. Minseung Choi, Diane P Genereux, Jamie Goodson, Haneen Al-Azzawi, Shannon Q. Allain, Noah Simon, Stan Palasek, Carol B. Ware, Chris Cavanaugh, Daniel G. Miller, Winslow C. Johnson, Kevin D. Sinclair, Reinhard Stöger, Charles D. Laird

 

Transient Reduction of DNA Methylation at the Onset of Meiosis in Male Mice. Valeriya Gaysinskaya, Brendan F. Miller, Godfried W. van der Heijden, Kasper D. Hansen, Alex Bortvin

 

 

Tripolar mitosis drives the association between maternal genotypes of PLK4 and aneuploidy in human preimplantation embryos. Rajiv C. McCoy, Louise J. Newnham, Christian S. Ottolini, Eva R. Hoffmann, Katerina Chatzimeletiou, Omar E. Cornejo, Qiansheng Zhan, Nikica Zaninovic, Zev Rosenwaks, Dmitri A. Petrov, Zachary P. Demko, Styrmir Sigurjonsson, Alan H. Handyside

 

 

ketu mutant mice uncover an essential meiotic function for the ancient, putative RNA helicase YTHDC2. Devanshi Jain, M. Rhyan Puno,Kathryn V. Anderson, Scott Keeney

 

rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline. Devanshi Jain, Cem Meydan, Julian Lange, Corentin Claeys Bouuaert, Christopher E Mason, Kathryn V Anderson, Scott Keeney

 

Spatially varying cis-regulatory divergence in Drosophila embryos elucidates cis-regulatory logic. Peter A. Combs, Hunter B. Fraser

 

A non-catalytic role of TET3 promotes open chromatin and enhances global transcription. Christel Krueger, Julian R. Peat, Melanie A. Eckersley-Maslin, Timothy A. Hore, Hisham Mohammed, Simon R. Andrews, Wendy Dean, Wolf Reik

 

 

 

A Mechanism of Cohesin-Dependent Loop Extrusion Organizes Zygotic Genome Architecture. Johanna Gassler, Hugo B. Brandao, Maxim Imakaev, Ilya M. Flyamer, Sabrina Ladstatter, Wendy A. Bickmore, Jan-Michael Peters, Leonid A. Mirny, Kikue Tachibana-Konwalski

 

Cyclin G And The Polycomb Repressive Complexes PRC1 And PR-DUB Cooperate For Developmental Stability. Delphine Dardalhon-Cumenal, Jerome Deraze, Camille A. Dupont, Valerie Ribeiro, Anne Coleno-Costes, Juliette Pouch, Stephane Le Crom, Helene Thomassin-Bourrel, Vincent Debat, Neel B. Randsholt, Frederique Peronnet

 

Cftr Modulates Wnt/β-Catenin Signaling and Stem Cell Proliferation in Murine Intestine. Ashlee M. Strubberg, Jinghua Liu, Nancy M. Walker, Casey D. Stefanski, R. John MacLeod, Scott T. Magness, Lane L. Clarke

 

CTCF mediated genome architecture regulates the dosage of mitotically stable mono-allelic expression of autosomal genes. Keerthivasan Raanin Chandradoss, Kuljeet Singh Sandhu

 

Cryo-ET reveals nucleosome reorganization in condensed mitotic chromosomes in vivo. Shujun Cai, Chen Chen, Zhi Yang Tan, Jian Shi, Lu Gan

 

Maternal RNA-directed DNA methylation is required for seed development in Brassica rapa. Jeffrey Grover, Timmy Kendall, Abdul Baten, Graham J. King, Rebecca A. Mosher

 

Frequent paramutation-like features of natural epialleles in tomato. Quentin Gouil, David Baulcombe

 

Regulatory divergence of flowering time genes in the allopolyploid Brassica napus. Marc Jones, Nick Pullen, Rachel Wells, Martin Trick, Judith Irwin, Richard Morris

 

The roles of Conserved Domains in DEMETER-Mediated Active DNA Demethylation in planta. Changqing Zhang, Yu-Hung Hung, Xiang-Qian Zhang, Dapeng Zhang, Wenyan Xiao, Lakshminarayan M. Iyer, L. Aravind, Jin Hoe Huh, Tzung-Fu Hsieh

 

Ubiquitin-related genes are differentially expressed in isogenic lines contrasting for pericarp cell size and grain weight in hexaploid wheat. Jemima Brinton, James Simmonds, Cristobal Uauy

 

The genetic architecture of the network underlying flowering time variation in Arabidopsis thaliana. Eriko Sasaki, Florian Frommlet, Magnus Nordborg

 

Somatic developmental defects in dmrad51/spnA mutant show low temperature sensitivity with enhanced genomic damages and cell death. Chaitali Khan, Sonia Muliyil,Champakali Ayyub, Basuthkar J. Rao

 

Induction of X-chromosome Inactivation by the Histone Demethylase SMCX/KDM5C. Srimonta Gayen, Emily Maclary, Yumie Murata-Nakamura, Christina N. Vallianatos, Robert S. Porter, Patricia M. Garay, Shigeki Iwase, Sundeep Kalantry

 

Incomplete MyoD-induced transdifferentiation is associated with chromatin remodeling deficiencies. Dinesh Manandhar, Lingyun Song, Ami Kabadi, Jennifer Kwon, Lee Edsall, Melanie Ehrlich, Koji Tsumagari, Charlie Gersbach, Gregory Crawford, Raluca Gordan

 

Heterogeneity and Intrinsic Variation in Spatial Genome Organization. Elizabeth Finn, Gianluca Pegoraro, Hugo B. Brandao, Anne-Laure Valton, Marlies E. Oomen, Job Dekker, Leonid Mirny, Tom Misteli

 

Assessing eRNAs associated with a cytokine-sensing mammary super-enhancer. Chaochen Wang, Tyler Kuhns, Christian Reinbold, Michaela Willi, Lothar Hennighausen

 

Mitotic chromosomes fold by condensin-dependent helical winding of chromatin loop arrays. Johan H. Gibcus, Kumiko Samejima, Anton Goloborodko, Itaru Samejima, Natalia Naumova, Masato Kanemaki, Linfeng Xie, James R. Paulson, William C. Earnshaw, Leonid A. Mirny, Job Dekker

 

Inbred or Outbred? Genetic diversity in laboratory rodent colonies. Thomas D. Brekke, Katherine A. Steele, John F. Mulley

 

| Stem cells, regeneration & disease modelling

Inter-homologue repair in fertilized human eggs? Dieter Egli, Michael Zuccaro, Michal Kosicki, George Church, Allan Bradley, Maria Jasin

 

Committed hemopoietic progenitors, not stem cells, are the principal responders to Hox gene transduction. Harvey Lim, Salima Janmohamed, Patricia Benveniste, Robert Herrington, Mary Barbara, Catherine Frelin, Deborah Hyam, Christopher Paige, Juan-Carlos Zuniga-Pflucker, Carol Stocking, Jana Krosl, Guy Sauvageau, Norman Iscove

 

BMP signalling is critical for maintaining homeostasis of hair follicles and intestine in adult mice. Aditi Nag, Pallavi Nigam, Abhishek L. Narayanan, Megha Kumar, Ritika Ghosal, Jonaki Sen, Amitabha Bandyopadhyay

 

Accelerated human liver progenitor generation from pluripotent stem cells by inhibiting formation of unwanted lineages. Lay Teng Ang, Antson Tan, Matias Ilmari Autio, Joanne Su-hua Goh, Siew Hua Choo, Kian Leong Lee, Bangfen Pan, Jianmin Tan, Jane Jia Hui Lee, Isabelle Kai Xin Yeo, Chloe Jin Yee Wong, Jen Jen Lum, Chet Hong Loh, Christina Ying Yan Lim, Jueween Ling Li Oh, Cheryl Pei Lynn Chia, Angela Chen, Qing Feng Chen, Irving Weissman, Kyle M. Loh, Bing Lim

 

Transgene-free hematopoietic stem and progenitor cells from human induced pluripotent stem cells. Laurence Guyonneau-Harmand, Bruno L’Homme, Brigitte Birebent, Christophe Desterke, Nathalie Chevallier, Loic Garcon, Helene Lapillonne, Marc Benderitter, Francois Delhommeau, Thierry Jaffredo, Alain Chapel, Luc Douay

 

 

CBFβ initiates the hematopoietic stem cell program without obligatory binding to RUNX. Aldo Ciau-Uitz, Philip Pinheiro, Arif Kirmizitas, Claire Fernandez, Roger Patient

 

Single-cell RNA-Sequencing uncovers transcriptional states and fate decisions in haematopoiesis. Emmanouil I Athanasiadis, Jan Botthof, Helena Andres, Lauren Ferreira, Pietro Lio, Ana Cvejic

 

Assessment of clonal kinetics reveals multiple trajectories of dendritic cell development. Dawn Lin, Andrey Kan, Jerry Gao, Edmund Crampin, Philip D. Hodgkin, Shalin H. Naik

 

Regulation of mesenchymal stem cell function by TGFβ-1 on mast cell extracellular vesicles — role of endosomal retention. Yanan Yin, Ganesh Vilas Shelke, Su Chul Jang, Cecilia Lasser, Stefan Wennmalm, Hans Jurgen Hoffmann, Jonas Nilsson, Li Li, Yong Song Gho, Jan Lotvall

 

 

Epigenomic and 3D genome architecture in naïve and primed human embryonic stem cell states. Stephanie Battle, Naresh Doni Jayavelu, Robert N. Azad, Jennifer Hesson, Faria N. Ahmed, Joseph A. Zoller, Julie Mathieu, Hannele Ruohola-Baker, Carol B. Ware, Raymond Hawkins

 

Resolution of Reprogramming Transition States by Single Cell RNA-Sequencing. Lin Guo, Xiaoshan Wang, Mingwei Gao, Lihui Lin, Junqi Kuang, Yuanbang Mai, Fang Wu, He Liu, Jiaqi Yang, Shilong Chu, Hong Song, Yujian Liu, Jiadong Liu, Jinyong Wang, Guangjin Pan, Andrew P. Hutchins, Jing Liu, Jiekai Chen, Duanqing Pei

 

Delayed activation of the DNA replication licensing system in Lgr5(+) intestinal stem cells. Thomas Carroll, Ian Newton, Julian J. Blow, Inke Nathke

 

Expression of lamina proteins Lamin Dm0 and Kugelkern suppresses stem cell proliferation. Roman Petrovsky, Joerg Grosshans

 

BCL-3 enhances β-catenin signalling in colorectal tumour cells promoting a cancer stem cell phenotype. Danny N. Legge, Alex P. Shephard, Tracey J. Collard, Alexander Greenhough, Adam C. Chambers, Richard W. Clarkson, Christos Paraskeva, Ann C. Williams

 

Acquisition of cell migration defines NK cell differentiation from hematopoietic stem cell precursors. Barclay J. Lee, Emily M. Mace

 

Induction of differentiation and metabolic reprogramming in human hepatoma cells by adult human serum. Rineke H. Steenbergen, Martin Oti, Rob ter Horst, Wilson Tat, Chris Neufeldt, Alexandr Belovodskiy, Tiing Tiing Chua, Woo Jung Cho, Michael Joyce, Bas E. Dutilh, D. Lorne Tyrrell

 

On the numbers and division rates of stem cells in human tissues. Augusto Gonzalez

 

Activating the regenerative potential of Müller glia cells in a regeneration-deficient retina. Katharina Lust, Joachim Wittbrodt

 

Inhibition of granulocyte ROS production by opioids prevents regeneration. Elodie Labit, Lise Rabiller, Christophe Guissard, Mireille Andre, Christine Rampon, Corinne Barreau, Beatrice Cousin, Audrey Carriere, Margaux Raffin, Gilles Mithieux, Mohamad Ala Eddine, Bernard Pipy, Anne Lorsignol, Sophie Vriz, Cecile Dromard, Louis Casteilla

 

 

Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair. Juan Carlos Lopez-Baez, Zhiqiang Zeng, Witold Rybski, Leonie F. A. Huitema, Alessandro Brombin, Rodney M. Dale, Koichi Kawakami, Christoph Englert, Stefan Schulte-Merker, Nicholas D. Hastie, E. Elizabeth Patton

 

Loss of lrrk2 impairs dopamine catabolism, cell proliferation, and neuronal regeneration in the zebrafish brain. Stefano Suzzi, Reiner Ahrendt, Stefan Hans, Svetlana A. Semenova, Saygin Bilican, Shady Sayed, Sylke Winkler, Sandra Spiess, Jan Kaslin, Pertti Panula, Michael Brand

 

Replication of early and recent Zika virus isolates throughout mouse brain development. Amy B. Rosenfeld, David J. Doobin, Audrey L. Warren, Vincent R. Racaniello, Richard B. Vallee

 

Human macrophages survive and adopt activated genotypes in living zebrafish. Colin D. Paul, Alexus Devine, Kevin Bishop, Qing Xu, Kathryn M. Daly, Chaunte Lewis, Daniel S. Green, Jack R. Staunton, Swati Choksi, Zheng-Gang Liu, Raman Sood, Kandice Tanner

 

A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5. Lisanne van Leeuwen, Robert Evans, Kin Ki Jim, Theo Verboom, Xiaoming Fang, Aleksandra Bojarczuk, Jarema Malicki, Simon Johnston, Astrid van der Sar

 

A Zebrafish Model For Ocular Tuberculosis. Kevin Takaki, Lalita Ramakrishnan, Soumyava Basu

 

Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse. Kärt Tomberg, Randal Westrick, Emilee Kotnik, David Siemieniak, Guojing Zhu, Thomas Saunders, Audrey Cleuren, VDavid Ginsburg

 

Asleep at the Wheel: Forward Genetic ENU Mutagenesis Screen for Mouse Models of Chronic Fatigue Identifies a Mutation in Slc2a4 (GLUT4). Marleen H. M. de Groot, Carlos M. Castorena, Vivek Kumar, Jennifer A. Mohawk, Newaz I. Ahmed, Joseph S. Takahashi

 

 

Abnormal cell sorting underlies the unique X-linked inheritance of PCDH19 Epilepsy. Daniel Pederick, Kay Richards, Sandra Piltz, Simone Mandelstam, Russell Dale, Ingrid Scheffer, Jozef Gecz, Steve Petrou, James Hughes, Paul Thomas

 

Post-transcriptional remodelling is temporally deregulated during motor neurogenesis in human ALS models. Raphaelle Luisier, Giulia E. Tyzack, Claire E. Hall, Jernej Ule, Nicholas M. Luscombe, Rickie Patani

 

A Caenorhabditis elegans model of adenylosuccinate lyase deficiency reveals neuromuscular and reproductive phenotypes of distinct etiology. Adam R. Fenton, Haley N. Janowitz, Melanie R. McReynolds, Wenqing Wang, Wendy Hanna-Rose

 

Whole chromosome loss in tetraploid cells confers tumorigenic potential in a mouse allograft model. Rozario Thomas, Daniel H. Marks, Yvette Chin, Robert Benezra

 

Zinc detoxification: a functional genomics and transcriptomics analysis in Drosophila melanogaster cultured cells. Stephanie Mohr, Kirstin Rudd, Yanhui Hu, Wei Roc Song, Quentin Gilly, Michael Buckner, Benjamin E. Housden, Colleen Kelley, Jonathan Zirin, Rong Tao, Gabriel Amador, Katarzyna Sierzputowska, Aram Comjean, Norbert Perrimon

 

Expanding primary cells from mucoepidermoid and other salivary gland neoplasms for genetic and chemosensitivity testing. Ahmad M. Alamri, Xuefeng Liu, Jan K. Blancato, Bassem R. Haddad, Weisheng Wang, Xiaogang Zhong, Sujata Choudhary, Ewa Krawczyk, Bhaskar V. Kallakury, Bruce J. Davidson, Priscilla A. Furth

 

Monsters in the uterus: A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans. Hongyuan Wang, Yuan Zhao, Marina Ezcurra, Ann Gilliat, Josephine Hellberg, Alexandre Benedetto, Trin Athigapanich, Johannes Girstmair, Max Telford, Zhizhou Zhang, David Gems

 

Mitochondrial sirtuins sir-2.2 and sir-2.3 regulate lifespan in C. elegans. Sarah M. Chang, Melanie R. McReynolds,Wendy Hanna-Rose

 

Global accumulation of circRNAs during aging in Caenorhabditis elegans. Mariela Cortés-López, Matthew Gruner, Daphne A. Cooper, Hannah N. Gruner, Alexandru-Ioan Voda, Alexander van der Linden, Pedro Miura

 

Evo-devo & evo

Insulin resistance in cavefish as an adaptation to a nutrient-limited environment. Ariel Aspiras, Misty Riddle, Karin Gaudenz, Robert Peuss, Jenny Sung, Brian Martineau, Megan Peavey, Andrew Box, Julius A. Tabin, Suzanne McGaugh, Richard Borowsky, Clifford J. Tabin, Nicolas Rohner

 

 

Cellular, ultrastructural and molecular analyses of epidermal cell development in the planarian Schmidtea mediterranea. Li-Chun Cheng, Kimberly C. Tu, Chris W. Seidel, Sofia M. C. Robb, Fengli Guo, Alejandro Sánchez Alvarado

 

Differences in the genetic control of early egg development and reproduction between C. elegans and its parthenogenetic relative D. coronatus. Christopher Kraus, Philipp H. Schiffer, Hiroshi Kagoshima, Hideaki Hiraki, Theresa Vogt, Michael Kroiher, Yuji Kohara, Einhard Schierenberg

 

Dramatic evolution of body length due to post-embryonic changes in cell size in a newly discovered close relative of C. elegans. Gavin C. Woodruff, Patrick C. Phillips, Natsumi Kanzaki

 

Insights into regeneration from the genome, transcriptome and metagenome analysis of Eisenia fetida. Aksheev Bhambri, Neeraj Dhaunta, Surendra Singh Patel, Mitali Hardikar, Nagesh Srikakulam, Shruti Shridhar, Shamsudheen Vellarikkal, Hemant Suryawanshi, Rajesh Pandey, Rijith Jayarajan, Ankit Verma, Vikram Kumar, Abhishek Bhatt, Pradeep Gautam, Manish Rai, Jameel Ahmed Khan, Bastian Fromm, Kevin J. Peterson, Vinod Scaria, Sridhar Sivasubbu, Beena Pillai

 

 

Desiccation plasticity and diapause in the Argentinian pearlfish Austrolebias bellottii. Tom Van Dooren, Irma Varela-Lasheras

 

Maternal X chromosome upregulation in both sexes initiates dosage compensation evolution. Aline Muyle, Niklaus Zemp, Cecile Fruchard, Radim Cegan, Jan Vrana, Clothilde Deschamps, Raquel Tavares, Franck Picard, Roman Hobza, Alex Widmer, Gabriel Marais

 

Natural variation at FLOWERING LOCUS T2 mediates local adaptation in a key life history trait in European aspen. Jing Wang, Jihua Ding, Biyue Tan, Kathryn M. Robinson, Ingrid H. Michelson, Anna Johansson, Björn Nystedt, Douglas G. Scofield, Ove Nilsson, Stefan Jansson, Nathaniel R. Street, Pär K. Ingvarsson

 

Hemimetabolous genomes reveal molecular basis of termite eusociality. Mark C. Harrison, Evelien Jongepier, Hugh M. Robertson, Nicolas Arning, Tristan Bitard-Feildel, Hsu Chao, Christopher P. Childers, Huyen Dinh, Harshavardhan Doddapaneni, Shannon Dugan, Johannes Gowin, Carolin Greiner, Yi Han, Haofu Hu, Daniel S. T. Hughes, Ann-Kathrin Huylmans, Carsten Kemena, Lukas P. M. Kremer, Sandra L. Lee, Alberto Lopez-Ezquerra, Ludovic Mallet, Jose M. Monroy-Kuhn, Annabell Moser, Shwetha C. Murali, Donna M. Muzny, Saria Otani, Maria-Dolors Piulachs, Monica Poelchau, Jiaxin Qu, Florentine Schaub, Ayako Wada-Katsumata, Kim C. Worley, Qiaolin Xie, Guillem Ylla, Michael Poulsen, Richard A. Gibbs, Coby Schal, Stephen Richards, Xavier Belles, Judith Korb, Erich Bornberg-Bauer

 

Comprehensive phylogenomic analyses resolve cnidarian relationships and the origins of key organismal traits. Ehsan Kayal, Bentlage Bastian, M Sabrina Pankey, Aki Ohdera, Monica Medina, David C Plachetzki​, Allen Collins, Joseph F Ryan

 

Gene markers for exon capture and phylogenomics in ray-finned fishes. Jiamei Jiang, Hao Yuan, Xin Zheng, Qian Wang, Ting Kuang, Jingyan Li, Junning Liu, Shuli Song, Weicai Wang, Fangyaun Cheng, Hongjie Li, Junman Huang, Chenhong Li

 

 

The crowns have eyes: Multiple opsins found in the eyes of the Crown-of-Thorns Starfish Acanthaster planci. Elijah K. Lowe, Anders Garm, Esther Ullrich-Luter, Maria Ina Arnone

 

EVOLUTIONARY ANALYSIS OF CANDIDATE NON-CODING ELEMENTS REGULATING NEURODEVELOPMENTAL GENES IN VERTEBRATES. Francisco J. Novo

 

Gene expression drives the evolution of dominance. Christian D. Huber, Arun Durvasula, Angela M. Hancock, Kirk E. Lohmueller

 

On somatic constraints in the evolution of multicellularity. Andrii Rozhok, James DeGregori

 

Towards physical principles of biological evolution. Mikhail I Katsnelson, Yuri I. Wolf, Eugene V. Koonin

 

 

Cell biology

Size control in mammalian cells involves modulation of both growth rate and cell cycle duration. Clotilde Cadart, Sylvain Monnier, Jacopo Grilli, Rafaele Attia, Emmanuel Terriac, Buzz Baum, Marco Cosentino-Lagomarsino, Matthieu Piel

 

Positive Feedback Between Contractile Ring Myosin and Ring-Directed Cortical Flow Drives Cytokinesis. Renat Khaliullin, Rebecca Green, Linda Shi, Michael Berns, J. Sebastian Gomez-Cavazos, Arshad Desai, Karen Oegema

 

 

Phosphatase PP2A and microtubule pulling forces disassemble centrosomes during mitotic exit. Stephen J. Enos, Martin Dressler, Beatriz Ferreira Gomes, Anthony A. Hyman, Jeffrey B. Woodruff

 

Kif2 microtubule depolymerase is required for unequal cell division and localizes to a subdomain of cortical endoplasmic reticulum. Vlad Costache, Celine Hebras, Gerard Pruliere, Lydia Besnardeau, Margaux Failla, Richard R. Copley, David Burgess, Janet Chenevert, Alex McDougall

 

Rapid degradation and 3D CLEM of condensin reveal chromatin compaction uncoupled from chromosome architecture in mitosis. Kumiko Samejima, Daniel G. Booth, Hiromi Ogawa, James R. Paulson, Linfeng Xie, Cara A. Watson, Melpomeni Platani, Masato T. Kanemaki, William C. Earnshaw

 

Spindle asymmetry drives non-Mendelian chromosome segregation. Takashi Akera, Lukáš Chmátal, Emily Trimm, Karren Yang, Chanat Aonbangkhen, David M. Chenoweth, Carsten Janke, Richard M. Schultz, Michael A. Lampson

 

Kinesin-6 KIF20B is required for efficient cytokinetic furrowing and timely abscission in human cells. Kerstin M Janisch, Katrina C McNeely, Joseph M Dardick, Samuel H Lim, Noelle D Dwyer

 

Conformational states during vinculin unlocking differentially regulate focal adhesion properties. Dror Shlomo Chorev, Tova Volberg, Ariel Livne, Miriam Eisenstein, Bruno Martins, Zvi Kam, Brigitte Jockusch, Ohad Medalia, Michal Sharon, Benjamin Geiger.

 

The PtdIns3P-binding protein Phafin2 escorts macropinosomes through the cortical actin cytoskeleton. Kay Oliver Schink, Kia Wee Tan, Helene Spangenberg, Domenica Martorana, Marte Sneeggen, Coen Campsteijn, Camilla Raiborg, Harald Stenmark

 

 

Lhr and Hmr are required for sister chromatid detachment during anaphase but not for centromere function. Jacob A. Blum, Silvia Bonaccorsi, Marta Marzullo, Valeria Palumbo, Yukiko Yamashita, Daniel Barbash, Maurizio Gatti

 

Systematic analysis of atx-2 suppressors reveals a novel regulator of PAR-5/14-3-3sigma function during mitosis in Caenorhabditis elegans. Megan M. Gnazzo, Alex R. Villarreal, Ahna R. Skop

 

Microtubule dynamics regulates mitochondrial fission. Kritika Mehta, Manjyot Kaur Chug, Siddharth Jhunjhunwala, Vaishnavi Ananthanarayanan

 

TRIP6 inhibits the Hippo signaling pathway in response to tension at adherens junctions. Shubham Dutta, Sebastian Mana-Capelli, Murugan Paramasivam, Ishani Dasgupta, Heather Cirka, Kris Billiar, Dannel McCollum

 

The contributions of the actin machinery to endocytic membrane bending and vesicle formation. Andrea Picco,Wanda Kukulski, Hetty E. Manenschijn, Tanja Specht, John A. G. Briggs, Marko Kaksonen

 

Modelling

Memory effects in gene regulatory networks reveal key properties of dynamical spatial patterning. Edgar Herrera-Delgado, Ruben Perez-Carrasco, James Briscoe, Peter Sollich

 

 

A Rho-GTPase based model explains spontaneous collective migration of neural crest cell clusters. Brian Merchant, Leah Edelstein-Keshet, James Feng

 

Spontaneous Chiral Symmetry Breaking in Planar Polarized Epithelia. Jeremy Hadidjojo, David K. Lubensky

 

The Role of Criticality of Gene Regulatory Networks in Morphogenesis. Hyobin Kim, Hiroki Sayama

 

SOMSC: Self-Organization-Map for High-Dimensional Single-Cell Data of Cellular States and Their Transitions. Tao Peng, Qing Nie

 

Compartmental and spatial rule-based modeling with Virtual Cell (VCell). Mikhail L. Blinov, James C. Schaff, Dan Vasilescu, Ion I. Moraru, Judy E. Bloom, Leslie M. Loew

 

Tools & resources

| Imaging etc.

 

Dynamic, non-contact 3D sample rotation for microscopy. Frederic Berndt, Gopi Shah, Jan Brugues, Jan Huisken

 

 

Mechanical mapping of spinal cord development and repair in living zebrafish larvae using Brillouin microscopy. Raimund Schlüßler, Stephanie Möllmert, Shada Abuhattum, Conrad Möckel, Conrad Zimmermann, Jürgen Czarske, Jochen Guck

 

A scheme for 3-dimensional morphological reconstruction and force inference in the early C. elegans embryo. Muzhi Xu, Yicong Wu, Hari Shroff, Min Wu, Madhav Mani

 

Spatial protein analysis in developing tissues: a sampling-based image processing approach. Karolis Leonavicius, Christophe Royer, Antonio M. A. Miranda, Richard Tyser, Annemarie Kip, Shankar Srinivas

 

Structural and functional diversity of a dense sample of retinal ganglion cells. J. Alexander Bae, Shang Mu, Jinseop S. Kim, Nicholas L. Turner, Ignacio Tartavull, Nico Kemnitz, Chris S. Jordan, Alex D. Norton, William M. Silversmith, Rachel Prentki, Marissa Sorek, Celia David, Devon L. Jones, Doug Bland, Amy L. R. Sterling, Jungman Park, Kevin L. Briggman, H. Sebastian Seung, the EyeWirers

 

Leaf-GP: An Open and Automated Software Application for Measuring Growth Phenotypes for Arabidopsis and Wheat. Ji Zhou, Christopher Applegate, Albor Dobon Alonso, Daniel Reynolds, Simon Orford, Michal Mackiewicz, Simon Griffiths, Steven Penfield, Nick Pullen

 

An ensemble learning approach to auto-annotation for whole-brain C. elegans imaging. Stephen Wu, Yu Toyoshima, Moon Sun Jang, Manami Kanamori, Takayuki Teramoto, Yuishi Iwasaki, Takeshi Ishihara, Yuichi Iino, Ryo Yoshida

 

Labeling RNAs in live cells using malachite green aptamer scaffolds as fluorescent probes. Venkata Siddartha Yerramilli, Kyung Hyuk Kim

 

OptoGap: an optogenetics-enabled assay for quantification of cell-cell coupling in multicellular cardiac tissue. Jinzhu Yu, Patrick M. Boyle, Aleksandra Klimas, John C. Williams, Natalia A. Trayanova, Emilia Entcheva

 

X10 Expansion Microscopy Enables 25 nm Resolution on Conventional Microscopes. Sven Truckenbrodt, Manuel Maidorn, Dagmar Crzan, Hanna Wildhagen, Selda Kabatas, Silvio O. Rizzoli

 

3D Single-Molecule Super-Resolution Microscopy With A Tilted Light Sheet. Anna-Karin Gustavsson, Petar N. Petrov, Maurice Y. Lee, Yoav Shechtman, W. E. Moerner

 

Single-shot super-resolution total internal reflection fluorescence microscopy. Min Guo, Panagiotis Chandris, John Paul Giannini, Adam J. Trexler, Robert Fischer, Jiji Chen, Harshad D. Vishwasrao, Ivan Rey-Suarez, Yicong Wu, Clare M. Waterman, George H. Patterson, Arpita Upadhyaya, Justin Taraska, Hari Shroff

 

Intra-voxel incoherent motion magnetic resonance imaging of the living human fetus: the technique and within-subject reproducibility. Andras Jakab, Ruth Tuura, Raimund Kottke, Christian Kellenberger, Ianina Scheer

 

Ultra-fast super-resolution imaging of biomolecular mobility in tissues. Helen Miller, Jason Cosgrove, Adam J. M. Wollman, Peter J. O’Toole, Mark Coles, Mark C. Leake

 

A dual-mode mobile phone microscope using the onboard camera flash and ambient light. Antony Orth, Emma R Wilson, Jeremy Thompson, Brant C Gibson

 

Fast and Powerful Genome Wide Association Analysis of Dense Genetic Data with High Dimensional Imaging Phenotypes. Habib Ganjgahi, Anderson M. Winkler, David C. Glahn, John Blangero, Brian Donohue, Peter Kochunov, Thomas E. Nichols

 

Systematic analysis of cell phenotypes and cellular social networks in tissues using the histology topography cytometry analysis toolbox (histoCAT). Denis Schapiro, Hartland Warren Jackson, Swetha Raghuraman, Vito Riccardo Tomaso Zanotelli, Jana R Fischer, Daniel Schulz, Charlotte Giesen, Raul Catena,Zsuzsanna Varga, Bernd Bodenmiller

 

| Genome tools

Deeper sequencing at unexpected CRISPR/Cas9 off-target sites in vivo : A response to Editas, Intellia, Beacon, ToolGen and others. Kellie A. Schaefer, Wen-Hsuan Wu, Benjamin W. Darbro, Diana F. Colgan, Stephen H. Tsang, Alexander G. Bassuk, Vinit B. Mahajan

 

Inhibition of p53 improves CRISPR/Cas-mediated precision genome editing. Emma Haapaniemi, Sandeep K. Botla, Jenna Persson, Bernhard Schmierer, Jussi Taipale

 

The effect of sequence mismatches on binding affinity and endonuclease activity are decoupled throughout the Cas9 binding site. Liyang Zhang, Hans Tomas Rube, Harmen J. Bussemaker, Miles A. Pufall

 

NmeCas9 is an intrinsically high-fidelity genome editing platform. Nadia Amrani, Xin D. Gao, Pengpeng Liu, Ankit Gupta, Alireza Edraki, Raed Ibraheim, Kanae E. Sasaki, Lihua Julie Zhu, Scot A. Wolfe, Erik J. Sontheimer

 

 

Design and specificity of long ssDNA donors for CRISPR-based knock-in. Han Li, Kyle A. Beckman, Veronica Pessino, Bo Huang, Jonathan S. Weissman, Manuel D. Leonetti

 

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues. M. Ryan Corces, Alexandro E. Trevino, Emily G. Hamilton, Peyton G. Greenside, Nicholas A. Sinnott-Armstrong, Sam Vesuna, Ansuman T. Satpathy, Adam J. Rubin, Kathleen S. Montine, Beijing Wu, Arwa Kathiria, Seung Woo Cho, Maxwell R. Mumbach, Ava C. Carter, Maya Kasowski, Lisa A. Orloff, Viviana I. Risca, Anshul Kundaje, Paul A. Khavari, Thomas J. Montine, William J. Greenleaf, Howard Y. Chang

 

High resolution annotation of Zebrafish transcriptome using long-read sequencing. German Nudelman, Antonio Frasca, Brandon Kent, Kirsten Edepli-Sadler, Stuart C. Sealfon, Martin J. Walsh, Elena Zaslavsky

 

Transcriptomes of major renal collecting-duct cell types in mouse identified by single-cell RNA-Seq. Lihe Chen, Jae Wook Lee, Chung-Lin Chou, Anilkumar Nair, Maria Agustina Battistone, Teodor Paunescu, Maria Mekulova, Sylvie Breton, Jill W. Verlander, Susan Wall, Dennis Brown, Maurice B. Burg, Mark A. Knepper.

 

 

High throughput expression profiling and in situ screening of circular RNAs in tissues. Ammar Zaghlool,Adam Ameur, Chenglin Wu, Jakub Westholm, Adnan Niazi, Manimozhi Manivannan, Kelli Bramlett, Mats Nilsson, Lars Feuk

 

Scanpy for analysis of large-scale single-cell gene expression data. F. Alexander Wolf, Philipp Angerer, Fabian J. Theis

 

Advanced whole genome sequencing and analysis of fetal genomes from amniotic fluid. Qing Mao, Robert Chin, Weiwei Xie, Yuqing Deng, Huixin Xu, Rebecca Yu Zhang, Quan Shi, Erin E. Peters, Natali Gulbahce, Zhenyu Li, Fang Chen, Radoje Drmanac, Brock A. Peters

 

Active ribosome profiling with RiboLace. Massimiliano Clamer, Toma Tebaldi, Fabio Lauria, Paola Bernabo, Rodolfo F. Gomez-Biagi, Elena Perenthaler, Daniele Gubert, Laura Pasquardini, Graziano Guella, Ewout J. N. Groen, Thomas H. Gillingwater, Alessandro Quattrone, Gabriella Viero

 

Tagmentation-Based Mapping (TagMap) of Mobile DNA Genomic Insertion Sites. David L. Stern

 

A Large-Scale Binding and Functional Map of Human RNA Binding Proteins. Eric L Van Nostrand, Peter Freese, Gabriel A Pratt, Xiaofeng Wang, Xintao Wei, Steven M Blue, Daniel Dominguez, Neal A L Cody, Sara Olson, Balaji Sundararaman, Rui Xiao, Lijun Zhan, Cassandra Bazile, Louis Philip Benoit Bouvrette, Jiayu Chen, Michael O Duff, Keri Garcia, Chelsea Gelboin-Burkhart, Abigail Hochman, Nicole J Lambert, Hairi Li, Thai B Nguyen, Tsultrim Palden, Ines Rabano, Shashank Sathe, Rebecca Stanton, Ashley L Louie, Stefan Aigner, Julie Bergalet, Bing Zhou, Amanda Su, Ruth Wang, Brian A Yee, Xiang-Dong Fu, Eric Lecuyer, Christopher B Burge, Brenton Graveley, Gene W Yeo

 

Detection and removal of barcode swapping in single-cell RNA-seq data. Jonathan A. Griffiths, Aaron T. L. Lun, Arianne C. Richard, Karsten Bach, John C. Marioni

 

 

Nuclear transcriptomes at high resolution using retooled INTACT. Mauricio A. Reynoso, Germain C. Pauluzzi, Kaisa Kajala, Sean Cabanlit, Joel Velasco, Jeremie Bazin, Roger Deal, Neelima R. Sinha, Siobhan M. Brady, Julia Bailey-Serres

 

In situ genome editing method suitable for routine generation of germline modified animal models. Masato Ohtsuka, Hiromi Miura, Naomi Arifin, Shingo Nakamura, Kenta Wada, Channabasavaiah Gurumurthy, Masahiro Sato

 

TF2Network: predicting transcription factor regulators and gene regulatory networks in Arabidopsis using publicly available binding site information. Shubhada R. Kulkarni,Dries Vaneechoutte, Jan Van de Velde, Klaas Vandepoele

 

The Oyster River Protocol: A Multi Assembler and Kmer Approach For de novo Transcriptome Assembly. Matthew D MacManes

 

Characterizing a thermostable Cas9 for bacterial genome editing and silencing. Ioannis Mougiakos, Prarthana Mohanraju, Elleke F. Bosma, Valentijn Vrouwe, Max Finger Bou, Mihris I. S. Naduthodi, Alexander Gussak, Rudolf B. L. Brinkman, Richard van Kranenburg, John van der Oost

 

Nonivasive prenatal diagnosis of single-gene disorders using droplet digital PCR. Joan Camunas-Soler, Hojae Lee, Louanne Hudgins, Susan R Hintz, Yair J Blumenfeld, Yasser Y El-Sayed, Stephen R Quake

 

GIC: A computational method for predicting the essentiality of long noncoding lncRNAs. Pan Zeng, Ji Chen, Yuan Zhou, Jichun Yang, Qinghua Cui

 

Oasis2.0: improved online analysis of small RNA-seq data. Raza-Ur Rahman, Abhivyakti Gautam, Joern Bethune, Abdul Sattar, Maksims Fiosins, Daniel Sumner Magruder, Vincenzo Capece, Orr Shomroni, Stefan Bonn

 

COGEM: A Toolbox for Computational Genomics in Matlab. Theodore J. Perkins

 

Euplotid: A Linux-based platform to physically edit the genome. Diego Borges-Rivera

 

DrImpute: Imputing dropout events in single cell RNA sequencing data. Il-Youp Kwak, Wuming Gong, Naoko Koyano-Nakagawa, Daniel Garry

 

Efficient in situ barcode sequencing using padlock probe-based BaristaSeq. Xiaoyin Chen, Yu-Chi Sun, George M. Church, Je Hyuk Lee, Anthony M. Zador

 

Notos – a Galaxy tool to analyze CpN observed expected ratios for inferring DNA methylation types. Ingo Bulla, Benoît Aliaga, Virginia Lacal, Jan Bulla, Christoph Grunau, Cristian Chaparro

 

Chiron: Translating nanopore raw signal directly into nucleotide sequence using deep learning. Haotian Teng, Michael B. Hall, Tania Duarte, Minh Duc Cao, Lachlan Coin

 

SEA: The Small RNA Expression Atlas. Raza-Ur Rahman, Abdul Sattar, Maksims Fiosins, Abhivyakti Gautam, Daniel Sumner Magruder, Joern Bethune, Sumit Madan, Juliane Fluck, Stefan Bonn

 

Enabling cross-study analysis of RNA-Sequencing data. Qingguo Wang, Joshua Armenia, Chao Zhang, Alexander V Penson, Ed Reznik, Liguo Zhang, Thais Minet, Angelica Ochoa, Benjamin E Gross, Christine A Iacobuzio-Donahue, Doron Betel, Barry S Taylor, Jianjiong Gao, Nikolaus Schultz

 

DEsingle: A new method for single-cell differentially expressed genes detection and classification.Zhun Miao, View ORCID ProfileXuegong Zhang

 

SeedVicious: analysis of microRNA target and near-target sites. Antonio Marco

 

NeatSeq-Flow: A Lightweight Software for Efficient Execution of High Throughput Sequencing Workflows. Menachem Y. Sklarz, Michal Gordon, Vered Chalifa-Caspi

 

SureMap: Versatile, Error Tolerant, and High Sensitive Read Mapper. MohammadJavad Rezaei Seraji, Seyed Abolfazl Motahari

 

Research practice

 

 

The prehistory of biology preprints: a forgotten experiment from the 1960s. Matthew Cobb

 

Preprints as medium for communicating new ideas, hypotheses, data, analysis and beyond. Wenfa Ng

 

The GSS is an unreliable indicator of biological sciences postdoc population trends. Christopher Pickett, Adriana Bankston, Gary S. McDowell

 

A Data Citation Roadmap for Scientific Publishers. Helena Cousijn, Amye Kenall, Emma Ganley, Melissa Harrison,David Kernohan, Thomas Lemberger, Fiona Murphy, Patrick Polischuk, Simone Taylor, Maryann Martone, Timothy Clark

 

Science with no fiction: measuring the veracity of scientific reports by citation analysis. Peter Grabitz, Yuri Lazebnik, Joshua Nicholson, Sean Rife

 

The State of OA: A large-scale analysis of the prevalence and impact of Open Access articles. Heather Piwowar​​, Jason Priem​​, Vincent Larivière, Juan Pablo Alperin, Lisa Matthias, Bree Norlander, Ashley Farley, Jevin West, Stefanie Haustein

 

Imagining the ‘open’ university: Sharing scholarship to improve research and education. Erin C McKiernan

 

The democratization of data science education. Sean Kross​, Roger D Peng, Brian S Caffo, Ira Gooding, Jeffrey T Leek

 

Parallel sequencing lives, or what makes large sequencing projects successful. Javier Quilez,Enrique Vidal, Francois Le Dily, Francois Serra,Yasmina Cuartero, Ralph Stadhouders, Thomas Graf, Marc A. Marti-Renom, Miguel Beato,Guillaume Filion

 

The harmonic mean p-value and model averaging by mean maximum likelihood. Daniel John Wilson

 

Bioinformatics Core Competencies for Undergraduate Life Sciences Education. Melissa A. Wilson Sayres, Charles Hauser, Michael Sierk, Srebrenka Robic, Anne G. Rosenwald, Todd M. Smith, Eric W. Triplett, Jason J. Williams, Elizabeth Dinsdale, William Morgan, James M. Burnette III, Sam S. Donovan, Jennifer C. Drew, Sarah C. R. Elgin, Edison R. Fowlks, Sebastian Galindo-Gonzalez, Anya L. Goodman, Neal F. Grandgenett, Carlos C. Goller, John Jungck, Jeffrey D. Newman, William R. Pearson, Elizabeth Ryder, Rafael Tosado-Acevedo, William Tapprich, Tammy C. Tobin, Arlín Toro-Martínez, Lonnie R. Welch, Robin Wright, David Ebenbach, Kimberly C. Olney, Mindy McWilliams, Mark A. Pauley

 

Lessons Learned: Recommendations for Establishing Critical Periodic Scientific Benchmarking. Salvador Capella-Gutierrez, Diana de la Iglesia, Juergen Haas, Analia Lourenco, Jose Maria Fernandez Gonzalez, Dmitry Repchevsky, Christophe Dessimoz, Torsten Schwede, Cedric Notredame, Josep Lluis Gelpi, Alfonso Valencia

 

Bringing plants and soils to life through a simple role-playing activity. Michael E. Van Nuland, Miranda Chen, Benjamin J. England

 

Why not…

Horizontal gene cluster transfer increased hallucinogenic mushroom diversity. Hannah T. Reynolds, Vinod Vijayakumar, Emile Gluck-Thaler, Hailee B. Korotkin, Patrick B. Matheny, Jason C. Slot

 

Not such silly sausages: Northern quolls exhibit aversion to toads after training with toad sausages.Naomi Liza Indigo, James Smith, Jonathan Webb, Ben Phillips

 

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