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Tough decisions for the developing brain

Posted by , on 3 October 2014

To form complex organs, somatic stem cells proliferate and then differentiate during development. In this process, intrinsic factors, i.e. the sequential expression of transcriptional genes, and extrinsic factors, i.e. extracellular ...
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What do sperm have to do with brain tumors?

Posted by , on 2 October 2014

  This post was originally published in the Knoepfler Lab Stem Cell Blog.      Sometimes in science there are unexpected threads tying seemingly very different things together. Unraveling the ...
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Towards a synthetic embryo

Posted by , on 24 September 2014

Waddington, whose writings on the epigenetic landscape continue to influence developmental biology to this day, called the developing embryo “the most intriguing object that nature has to offer”(Waddington, 1966). The ...
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When real life becomes equations: Control of Epiblast and Primitive Endoderm specification during mouse preimplantation development.

Posted by , on 23 September 2014

During mouse preimplantation development, the zygote divides and forms three distinct lineages: one embryonic called the Epiblast (Epi) and two extraembryonic called trophectoderm (TE) and Primitive Endoderm (PrE). The first ...
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In Development this week (Vol. 141, Issue 19)

Posted by , on 23 September 2014

Here are the highlights from the current issue of Development:   Modelling fate decisions in the early mouse embryo In the early embryo, the first fate decision separates the trophectoderm ...
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The origin of blood

Posted by , on 4 September 2014

As for the origin of species, the question of the origin of blood during development has unleashed a lot of passion among the scientific community. As a matter of fact, ...
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Designing ChIP primers

Posted by , on 4 September 2014

Hello everyone, Recently I got assigned with the task of designing good primers for ChIP. My supervisor advised me to use the Primer BLAST tool from NCBI together with AmplifiX ...
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Researchers grow ‘seed’ of spinal cord tissue in a dish

Posted by , on 3 September 2014

Medical Research Council (MRC) scientists have for the first time managed to turn stem cells into the specialised cells that go on to form spinal cord, muscle and bone tissue ...
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In Development this week (Vol. 141, Issue 18)

Posted by , on 2 September 2014

Here are the highlights from the current issue of Development:   Mcc: a new player in gastrulation The mutated in molorectal cancer (Mcc) gene has been described as a tumour ...
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Yoshiki Sasai: stem cell Sensei

Posted by , on 21 August 2014

This obituary first appeared in Development.   Stefano Piccolo looks back at the life and research of his friend and colleague Yoshiki Sasai.   On 5 August 2014, Yoshiki Sasai died at ...
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