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Displaying posts in the category: Research

Tissue-specific genome editing in Ciona embryos by CRISPR/Cas9

Posted by , on 31 October 2014

Researchers have always been interested in tissue-specific loss of function to probe the role of specific genes in embryonic development, cell physiology and disease conditions. Migration of lateral plate primordial ...

A mechanism that allows a differentiated cell to reactivate as a stem cell revealed

Posted by , on 29 October 2014

The study, performed with fruit flies, describes a gene that determines whether a specialized cell conserves the capacity to become a stem cell again. Unveiling the genetic traits that favour ...

Biology and maths partner to understand life decisions

Posted by , on 26 October 2014

Starting with the one fertilized egg that we all once were, embryonic development is made of cell divisions and most importantly of cell decisions. These first life decisions are the ...

In Development this week (Vol. 141, Issue 21)

Posted by , on 21 October 2014

Here are the highlights from the new issue of Development:   Two top tips for angiogenesis The widely accepted model of angiogenic sprouting proposes that a single cell – the ...

Full-term development of quail chick by ICSI

Posted by , on 18 October 2014

The eggs of domestic birds have been used in the study of developmental biology, leading to the extensive accumulation of knowledge on embryonic development. However, the early events involved in ...

Flies with colon cancer help to unravel the genetic keys to disease in humans

Posted by , on 8 October 2014

Researchers generate for the first time Drosophila melanogaster with intestinal cancer and reveal key genetic factors behind human colon cancer. The scientists identify a human gene that favours the proliferation ...

In Development this week (Vol. 141, Issue 20)

Posted by , on 7 October 2014

Here are the highlights from the current issue of Development:   Small (molecule) steps to making bone The repair of cartilage and bone following damage remains a clinical challenge. Current ...

Tough decisions for the developing brain

Posted by , on 3 October 2014

To form complex organs, somatic stem cells proliferate and then differentiate during development. In this process, intrinsic factors, i.e. the sequential expression of transcriptional genes, and extrinsic factors, i.e. extracellular ...

What do sperm have to do with brain tumors?

Posted by , on 2 October 2014

  This post was originally published in the Knoepfler Lab Stem Cell Blog.      Sometimes in science there are unexpected threads tying seemingly very different things together. Unraveling the ...

Towards a synthetic embryo

Posted by , on 24 September 2014

Waddington, whose writings on the epigenetic landscape continue to influence developmental biology to this day, called the developing embryo “the most intriguing object that nature has to offer”(Waddington, 1966). The ...

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