Postdoc position in centrosome biology

Applications are invited from suitably qualified candidates for a full-time, fixed term position as a Postdoctoral Researcher in cell/ molecular biology at the University of Galway, Ireland.

106-24–Advert-(2)

Centrosomes are the principal microtubule organising centres in animal somatic cells. They assemble the poles of the mitotic spindle, regulate cell polarity and movement, and form the base of primary cilia. Changes in the number of centrosomes and in centrosome stability are frequently seen in cancer or in senescent cells. Such changes can cause significant problems in mitosis and cause cell death or aneuploidy. This project will explore how key centrosome structures are assembled and the molecular details of how they function after DNA damage and replicative senescence. Centrosomes are composed of one or two microtubule-based centrioles within a cloud of pericentriolar material. The successful candidate will explore centrosome functions during the cell cycle and after genotoxic stress or cellular senescence, using cell biology, molecular genetic and biochemical analyses to test the mechanisms that act at the centriole distal end and that control centrosome numerical homeostasis.

Essential Requirements:
• PhD in cell/ molecular biology, biochemistry or related area.
• Demonstrable experience in mammalian cell culture and gene targeting/ genome editing.
• Demonstrable research experience in microscopy (fluorescence and/ or electron).
• Demonstrable research experience in molecular biology.

Desirable Requirements:
• Experience in student project supervision.
• First author published/accepted research paper(s) in international peer-reviewed scientific literature.
• Specific research experience and expertise in centrosome and/ or ciliary biology.
• Specific research experience and expertise in DNA damage response.
• Specific research experience and expertise in protein biochemistry and/ or proteomics.

To Apply:
Applications to include a covering letter, CV, and the contact details of three referees should be sent, via e-mail (in Word or PDF only) to Professor Ciaran Morrison (ciaran.morrison@universityofgalway.ie). Reprints of papers or copies of degree certificates should not be included in the application. Please put reference number University of Galway 106-24 in subject line of e-mail application.